Subclinical Inflammation with Increased Neutrophil Activity in Healthy Twin Siblings Reflect Environmental Influence in the Pathogenesis of Inflammatory Bowel Disease

Zhulina, Yaroslava; Hahn-Strömberg, Victoria; Shamikh, A.; Peterson, Christer; Gustavsson, Anders; Nyhlin, Nils; Wickbom, Anders; Bohr, Johan; Bodin, Lennart; Tysk, Curt; Carlson, Marie; Halfvarson, Jonas

doi:10.1097/mib.0b013e318281f2d3

Cited by 29 publications

(32 citation statements)

References 30 publications

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“…The intestinal microbiota composition has been shown to be different in both ulcerative colitis (UC) and Crohn's disease (CD), and is generally characterised by a lower diversity and a decreased stability compared to healthy controls, which may lead to the loss of normal, regulatory immune effects of the microbiota . It is still unclear if alterations in microbiota composition are a cause or consequence of the ongoing inflammatory processes, or a combination of both …”

Section: Recommendations On Clinical Applications (Indications)mentioning

confidence: 99%

“…34,36,37 It is still unclear if alterations in microbiota composition are a cause or consequence of the ongoing inflammatory processes, or a combination of both. [38][39][40][41] A number of case studies showing positive effects of FMT in IBD have been published. [42][43][44][45][46][47][48][49] However, most of these studies involve low patient numbers, are mostly published in abstract form, and might be subjected to publication bias.…”

Section: Key Recommendations On Fmt In Ibdmentioning

confidence: 99%

See 1 more Smart Citation

Consensus report: faecal microbiota transfer – clinical applications and procedures

König¹,

Siebenhaar²,

Högenauer³

et al. 2016

Aliment Pharmacol Ther

101

102

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Section: Recommendations On Clinical Applications (Indications)mentioning

confidence: 99%

Section: Key Recommendations On Fmt In Ibdmentioning

confidence: 99%

Consensus report: faecal microbiota transfer – clinical applications and procedures

König¹,

Siebenhaar²,

Högenauer³

et al. 2016

Aliment Pharmacol Ther

101

102

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“…This expression is probably acquired, as NF-kB is present in the surface epithelium of mucosal biopsies of unaffected IBD twins, suggesting a preinflammatory status [118]. Neutrophil activity, measured by myeloperoxidase (MPO) and fecal calprotectin (FC), was more often increased in healthy twin siblings in discordant pairs with CD and UC, respectively [119].…”

Section: Inflammatory Bowel Diseasesmentioning

confidence: 99%

Lessons learned from twins in autoimmune and chronic inflammatory diseases

Generali

Ceribelli

Stazi

et al. 2017

Journal of Autoimmunity

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“…For example, neutrophil-and macrophage-derived cytokines are increased in IBD patients and animal models (Knutson et al 2013;Wine et al 2013). In fact, fecal calprotectin and myeloperoxidase, neutrophil products linked to bowel inflammation, are increased in healthy twins of IBD patients, suggesting a fundamental role for neutrophils in disease pathogenesis (Zhulina et al 2013).…”

Section: Innate Immunity and Host Defence: Bridging Between The Host mentioning

confidence: 99%

Host–microbe interactions in the gut: lessons learned from models of inflammatory bowel diseases

WineEytan

2014

LymphoSign Journal

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The mammalian gut is the richest immune organ in the body and serves as a central location for immune system development, processing, and education. Inflammatory bowel diseases (IBD) provide excellent models for studying both innate and adaptive responses to gut microbes and the host-immune system – microbe interactions in the gut. Microbes are linked to almost all of the known disease-associated genetic polymorphisms in IBD and are critical mediators of environmental effects (through food, hygiene, and infection). Human and animal-based research supports the central role of microbes in IBD pathogenesis at multiple levels. Animal models of IBD only develop in the presence of microbes, and co-housing mice that are genetically susceptible to gut inflammation with normal mice can lead to the development of bowel injury. Recent advances in research technologies, such as deep-sequencing that enables detailed compositional analyses, have revolutionized the study of host–microbe interactions in the gut; however, knowing which bacteria are present in the bowel is likely not sufficient. The function of the microbiota as a community is recognized as a critical factor for gut homeostasis. Animal models of IBD have provided critical insight into basic biology and disease pathogenesis, especially regarding the role of microbes in IBD pathogenesis. Although many of these recent discoveries on host–microbe interactions are not yet applied to patient care, these basic observations will certainly revolutionize patient care in the future. Using such data, we may be able to predict risk of disease, define biological subtypes, establish tools for prevention, and even cure IBD using microbes or their products. A broad spectrum of therapeutic tools spanning from fecal transplantation, probiotics, prebiotics, and microbial products to microbe-tailored diets may supplement current IBD treatments.

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Subclinical Inflammation with Increased Neutrophil Activity in Healthy Twin Siblings Reflect Environmental Influence in the Pathogenesis of Inflammatory Bowel Disease

Abstract: Background and aim: The mechanisms behind increased f-Calprotectin (FC) in healthy

Cited by 29 publications

References 30 publications

Consensus report: faecal microbiota transfer – clinical applications and procedures

Consensus report: faecal microbiota transfer – clinical applications and procedures

Lessons learned from twins in autoimmune and chronic inflammatory diseases

Host–microbe interactions in the gut: lessons learned from models of inflammatory bowel diseases

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