Subclinical Left Ventricular Dysfunction in Asymptomatic Chronic Mitral Regurgitation Patients with Normal Ejection Fraction: A Combined Tissue Doppler and Velocity Vector Imaging-Based Study

Yurdakul, Selen; Tayyareci, Yelda; Yildirimturk, F.E.S.C. Ozlem; Memiç, Kadriye; Aytekin, F.E.S.C. Vedat; Aytekin, Fuat

doi:10.1111/j.1540-8175.2011.01428.x

Cited by 21 publications

(2 citation statements)

References 48 publications

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“…The clinical use of PW TDI for the assessment of LV mechanical function in horses with valvular regurgitation has not been previously described. In humans and For legend, see Table 3. dogs with valvular regurgitation, it has been suggested that TDI might aid in the detection of subclinical LV dysfunction [31][32][33] and the prediction of increased pulmonary capillary wedge pressure 34 and congestive heart failure. [35][36][37][38] Detection of early subclinical LV dysfunction in horses may provide useful additional information, for example, when investigating horses with murmurs detected on prepurchase examinations or during the evaluation of horses with poor performance.…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed‐Wave Tissue Doppler Imaging

Koenig

Mitchell

Schwarzwald

2017

Veterinary Internal Medicne

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BackgroundAssessment of left ventricular (LV) function by tissue Doppler imaging (TDI) is not well established in horses with heart disease.ObjectivesTo describe the use of pulsed‐wave (PW) TDI for the assessment of LV function, establish reference intervals, investigate effects of mitral regurgitation (MR), aortic regurgitation (AR), and primary myocardial disease (MD), and provide proof of concept for the use of PW TDI in Warmblood horses with heart disease.AnimalsThirty healthy horses, 38 horses with MR, 25 with AR, 8 with MD.MethodsEchocardiograms were retrospectively analyzed. Reference intervals were calculated. PW TDI indices of healthy horses and horses with MR, AR, and MD were compared by one‐way ANOVA and Dunnett's test.ResultsA complete set of PW TDI variables could be obtained in 94 of 101 horses. Variables corresponding to isovolumic intervals were most difficult to measure. Valvular regurgitation influenced variables describing isovolumic contraction and ejection. Horses with MD had significantly shortened ETm (−118.5 [−154.1 to −82.9] ms; mean difference [95% CI of difference of means]), increased PEPm/ETm (0.11 [0.05 to 0.17]), prolonged IMPm (0.28 [0.18 to 0.37]), increased S 1 (8.9 [5.2 to 12.6] cm/s), and decreased E 1 (−2.6 [−4.7 to −0.5] cm/s), E m (−14.2 [−19.9 to −8.5] cm/s), and E m/A m ratio (−1.6 [−2.6 to −0.6]).Conclusions and Clinical ImportancePulsed‐wave TDI might be useful for detection of LV dysfunction in horses with primary MD. The clinical value of TDI in horses with MR and AR remains uncertain.

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Section: Discussionmentioning

confidence: 99%

Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed‐Wave Tissue Doppler Imaging

Koenig

Mitchell

Schwarzwald

2017

Veterinary Internal Medicne

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“…12 A number of studies also suggest that SR imaging may detect subclinical LV dysfunction in a variety of diseases before LV systolic function was established. 13,14 Yurdakul et al 15 demonstrated that S/SR values of MR severity were decreased. Their study population consisted of 54 patients with isolated non-ischemic MR and 30 healthy aged matched subjects were examined (mild MR n=7, moderate n=29 and severe MR n=18).…”

Section: Discussionmentioning

confidence: 99%

Relationship between the severity of mitral regurgitation, left ventricular dysfunction and plasma brain natriuretic peptide level: An observational strain imaging study

Elbey

Arslan²,

Aksakal³

et al. 2012

J Clin Exp Invest

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Bu çalışmada mitral yetersizliği ve strain/strain rate (S/SR) ekokardiyografi ile tespit edilen sol ventrikül disfonksiyonunun derecesi ile plazma beyin natriüretik peptid seviyesi arasındaki ilişkinin araştırılması amaçlanmıştır. Gereç ve yöntem: Mevcut çalışma kesitsel, gözlemsel bir çalışmadır. Bu çalışmaya polikliniğimize başvurmuş olan ardışık 31 mitral yetersizliği hastası (15'i [%48,4] erkek) ve kontrol grubu olarak 25 sağlıklı birey (12'si [%48,0] erkek) alınmıştır. Hastalar orta derecede mitral yetmezliği olanlar (n=14 [%45,2] ve ileri derecede mitral yetmezliği olanlar (n=17 [%54,8] olarak iki gruba ayrılmışlar ve üç grupta sol ventrikül duvar segmentlerinin maksimum strain / strain rate ölçümleri kaydedilmiş, plazma beyin natriüretik peptit seviyeleri ölçülmüştür. Bulgular: İleri MY olan hastalarda orta MY ve kontrol grubu ile karşılaştırıldığında ileri MY grubunda sol ventrikül segment S/SR değerlerinde daha belirgin azalma izlendi (p<0,001). Sonuç: MY olan hastaların her ne kadar konvansiyonel ekokardiyografik olarak sol ventrikül fonksiyonları normal olmasına rağmen ileri MY olan grubun sol ventrikül fonksiyonlarında subklinik bozulma izlendi.

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Advanced echocardiographic techniques

Perry

Joseph

2012

Australas J Ultrason Med

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Echocardiography has advanced significantly since its first clinical use. The move towards more accurate imaging and quantification has driven this advancement. In this review, we will briefly focus on three distinct but important recent advances, three‐dimensional (3D) echocardiography, contrast echocardiography and myocardial tissue imaging. The basic principles of these techniques will be discussed as well as current and future clinical applications.

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Subclinical Left Ventricular Dysfunction in Asymptomatic Chronic Mitral Regurgitation Patients with Normal Ejection Fraction: A Combined Tissue Doppler and Velocity Vector Imaging-Based Study

Abstract: LV long-axis functions are important markers of LV contractility in MR patients. Novel echocardiographic techniques may provide additional data on subclinical changes in the LV and give way to the optimal timing for the surgery in severe MR patients.

Cited by 21 publications

References 48 publications

Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed‐Wave Tissue Doppler Imaging

Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed‐Wave Tissue Doppler Imaging

Relationship between the severity of mitral regurgitation, left ventricular dysfunction and plasma brain natriuretic peptide level: An observational strain imaging study

Advanced echocardiographic techniques

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