Subclinical Left Ventricular Dysfunction in Asymptomatic Severe Aortic Regurgitation Patients with Normal Ejection Fraction: A Combined Tissue Doppler and Velocity Vector Imaging Study

Tayyareci, Yelda; Yıldırımtürk, Özlem; Aytekin, Vedat; Demiroglu, I.C. Cemsid; Aytekin, Saide

doi:10.1111/j.1540-8175.2009.01053.x

Cited by 32 publications

(28 citation statements)

References 32 publications

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“…The fact that none of the variables was significantly altered in horses with moderate‐to‐severe AR suggests that the clinical use of TDI for the assessment of LV function in horses with AR may be limited. This seems to be in contrast to findings in people, where reduced S m , E m , and A m and prolonged IVCT m , IVRT m , and IMP m provide indices of subclinical LV dysfunction that may serve as prognostic indicators in asymptomatic patients with severe aortic regurgitation 11, 12, 13, 42, 43. However, it should be noted that classification of valvular regurgitation based on receiving chamber analysis of the regurgitant jet may not entirely reflect the hemodynamic status in individual horses.…”

Section: Discussioncontrasting

confidence: 72%

“…Both in people and in small animals, the clinical applicability of TDI has been established and the modality has been successfully applied for the assessment of systolic and diastolic LV function and estimation of ventricular filling pressures 4, 5, 6, 7. It might have diagnostic and prognostic implications in cats and dogs with cardiomyopathies8, 9, 10 and aid in the diagnosis of subclinical LV dysfunction in asymptomatic human patients with aortic and mitral regurgitation 11, 12, 13…”

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confidence: 99%

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Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed‐Wave Tissue Doppler Imaging

Koenig

Mitchell

Schwarzwald

2017

Veterinary Internal Medicne

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BackgroundAssessment of left ventricular (LV) function by tissue Doppler imaging (TDI) is not well established in horses with heart disease.ObjectivesTo describe the use of pulsed‐wave (PW) TDI for the assessment of LV function, establish reference intervals, investigate effects of mitral regurgitation (MR), aortic regurgitation (AR), and primary myocardial disease (MD), and provide proof of concept for the use of PW TDI in Warmblood horses with heart disease.AnimalsThirty healthy horses, 38 horses with MR, 25 with AR, 8 with MD.MethodsEchocardiograms were retrospectively analyzed. Reference intervals were calculated. PW TDI indices of healthy horses and horses with MR, AR, and MD were compared by one‐way ANOVA and Dunnett's test.ResultsA complete set of PW TDI variables could be obtained in 94 of 101 horses. Variables corresponding to isovolumic intervals were most difficult to measure. Valvular regurgitation influenced variables describing isovolumic contraction and ejection. Horses with MD had significantly shortened ETm (−118.5 [−154.1 to −82.9] ms; mean difference [95% CI of difference of means]), increased PEPm/ETm (0.11 [0.05 to 0.17]), prolonged IMPm (0.28 [0.18 to 0.37]), increased S 1 (8.9 [5.2 to 12.6] cm/s), and decreased E 1 (−2.6 [−4.7 to −0.5] cm/s), E m (−14.2 [−19.9 to −8.5] cm/s), and E m/A m ratio (−1.6 [−2.6 to −0.6]).Conclusions and Clinical ImportancePulsed‐wave TDI might be useful for detection of LV dysfunction in horses with primary MD. The clinical value of TDI in horses with MR and AR remains uncertain.

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Section: Discussioncontrasting

confidence: 72%

mentioning

confidence: 99%

Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed‐Wave Tissue Doppler Imaging

Koenig

Mitchell

Schwarzwald

2017

Veterinary Internal Medicne

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“…It can detect even small changes in the contractile function and is well correlated with the invasive or noninvasive measures of LV dP/dt [13,17]. Therefore, IVA can be used as a valuable and easy parameter for the quantification of global systolic function in various cardiac diseases [26,27].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of mitral stenosis severity on the left ventricular systolic function using isovolumic myocardial acceleration

Ertürk

Aksu²,

Çelik³

et al. 2014

Cardiol J

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“…The chronic effects of abnormal loading from valvular disease on myocardial function may be difficult to detect by conventional means, and strain imaging may play a role (61)(62)(63)(64)(65)(66)(67). Delgado et al (62) demonstrated that patients with severe aortic stenosis and preserved EF exhibited decreased radial, circumferential, and longitudinal speckle tracking strain.…”

Section: Applications Of Strain Imaging For Effects Of Valvular Heartmentioning

confidence: 98%

Echocardiographic Assessment of Myocardial Strain

Gorcsan¹,

Tanaka²

2011

Journal of the American College of Cardiology

416

305

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Echocardiographic strain imaging, also known as deformation imaging, has been developed as a means to objectively quantify regional myocardial function. First introduced as post-processing of tissue Doppler imaging velocity converted to strain and strain rate, strain imaging has more recently also been derived from digital speckle tracking analysis. Strain imaging has been used to gain greater understanding into the pathophysiology of cardiac ischemia and infarction, primary diseases of the myocardium, and the effects of valvular disease on myocardial function, and to advance our understanding of diastolic function. Strain imaging has also been used to quantify abnormalities in the timing of mechanical activation for heart failure patients undergoing cardiac resynchronization pacing therapy. Further advances, such as 3-dimensional speckle tracking strain imaging, have emerged to provide even greater insight. Strain imaging has become established as a robust research tool and has great potential to play many roles in routine clinical practice to advance the care of the cardiovascular patient. This perspective reviews the physiology of myocardial strain, the technical features of strain imaging using tissue Doppler imaging and speckle tracking, their strengths and weaknesses, and the state-of-the-art present and potential future clinical applications.

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Subclinical Left Ventricular Dysfunction in Asymptomatic Severe Aortic Regurgitation Patients with Normal Ejection Fraction: A Combined Tissue Doppler and Velocity Vector Imaging Study

Cited by 32 publications

References 32 publications

Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed‐Wave Tissue Doppler Imaging

Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed‐Wave Tissue Doppler Imaging

Evaluation of the effect of mitral stenosis severity on the left ventricular systolic function using isovolumic myocardial acceleration

Echocardiographic Assessment of Myocardial Strain

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