Subclinical Saccadic Eye Movement Dysfunction in Pediatric Multiple Sclerosis

Yousef, Andrew; Devereux, Michael; Gourraud, Pierre‐Antoine; Jonzzon, Soren; Suleiman, Leena; Waubant, Emmanuelle; Green, Ari; Graves, Jennifer

doi:10.1177/0883073818807787

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…Определение времени движения глаз показало задержку 60 мс при саккадических движениях у пациентов с РС. Данный прибор может быть использован как для диагностики проявлений РС, так и для мониторинга эффективности терапии на основе изменения выраженности симптомов [47,48].…”

Section: рассеянный склерозunclassified

Remote telemedicine technologies in pediatric neurology.

Shaderkina,

Alekseeva,

Batysheva

et al. 2023

RJTEH

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Introduction. Neurologic disorders make a significant contribution to overall morbidity. For example, in recent years in Moscow, the overall incidence of diseases of the nervous system in children is 7637.1 per 100.000 people. The chronic course of neurologic disorders and the need for long-term rehabilitation determine the widespread use of digital technologies in this area. Materials and methods. A literature review was conducted in the PubMed database. The inclusion criteria for studies were the use of digital technologies and the participation of patients under 18 years of age in testing and evaluating the effectiveness of these methods. Results. In this paper we reviewed the use of digital technologies in disorders such as cerebral palsy (CP), epilepsy, headaches including migraines, and multiple sclerosis. Modern wearable diagnostic and neuroimaging devices have been described. In the treatment of cerebral palsy, home rehabilitation options are receiving high interest. The most common area in which remote monitoring is used is the chronic headaches monitoring. Many available solutions have been developed in this area, such as digital diaries, which are used to identify the causes and triggers of migraines exacerbations and tension headaches. Telemedicine consultations increase patient access to neurological and neurosurgical care, and use of teleconsultations is increasing rapidly in recent years. Conclusion. Thus, there is currently an active development of digital technologies in pediatric neurology. Telemedicine consultations, virtual and augmented reality technologies, and the use of applications on smartphones and related devices are becoming new high-quality and objective methods of patient management.

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Section: рассеянный склерозunclassified

Remote telemedicine technologies in pediatric neurology.

Shaderkina,

Alekseeva,

Batysheva

et al. 2023

RJTEH

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show abstract

“… 58 Even in the very young, with pediatric onset MS and no discernible disability on examination, saccadic latencies can distinguish eyes of patients with MS from those of healthy controls. 59 For rapidly quantifying disease burden largely driven by the brainstem and cerebellum (key contributors to overall disability scores), eye-tracking approaches offer objective, reliable means to collect these data.…”

Section: Efferent Visual System and Oculometricsmentioning

confidence: 99%

Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders

Graves

Oertel

Walt

et al. 2022

Neurol Neuroimmunol Neuroinflamm

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The visual system offers unparalleled precision in the assessment of neuroaxonal damage. With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent visual dysfunction, outcome measures capturing these deficits provide insight into neuroaxonal injury, even in those with minimal disability. Ideal for use in clinical trials, visual measures are generally inexpensive, accessible, and reproducible. Quantification of visual acuity, visual fields, visual quality of life, and electrophysiologic parameters allows assessment of function, whereas optical coherence tomography (OCT) provides reliable measures of the structural integrity of the anterior afferent visual pathway. The technology of oculomotor biometrics continues to advance, and discrete measures of fixation, smooth pursuit, and saccadic eye movement abnormalities are ready for inclusion in future trials of MS progression. Visual outcomes allow tracking of neuroaxonal injury and aid in distinguishing MS from diseases such as neuromyelitis optica spectrum disorder (NMOSD) or myelin oligodendrocyte glycoprotein antibody–associated diseases (MOGAD). OCT has also provided unique insights into pathophysiology, including the identification of foveal pitting in NMOSD, possibly from damage to Müller cells, which carry an abundance of aquaporin-4 channels. For some study designs, the cost-benefit ratio favors visual outcomes over more expensive MRI outcomes. With the next frontier of therapeutics focused on remyelination and neuroprotection, visual outcomes are likely to take center stage. As an international community of collaborative, committed, vision scientists, this review by the International MS Visual System Consortium (IMSVISUAL) outlines the quality standards, informatics, and framework needed to routinely incorporate vision outcomes into MS and NMOSD trials.

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“…[ 162 ] Various ocular abnormal movements can appear in MS, with internuclear ophthalmoplegia (INO) being the most frequent, constructing 30% of all MS cases. [ 162 163 164 165 ] As INO progresses, saccadic latency, velocity, and range of motion are also affected progressively, leading to visual confusion, oscillopsia, reading fatigue, diplopia, and loss of stereopsis. [ 166 167 ] One case of ocular flutter has also been reported in MOG-Ab disease.…”

Section: E Ye M Ovement D ...mentioning

confidence: 99%

Movement Disorder in Demyelinating Disease

Pandey¹,

Singh²

2022

Annals of Indian Academy of Neurology

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Movement disorders may be one of the neurological manifestations of demyelinating disorders. They can manifest in Parkinsonism or a wide spectrum of hyperkinetic movement disorders including tremor, paroxysmal dyskinesia, dystonia, chorea, and ballism. Some of these disorders occur during an acute episode of demyelination, whereas others can develop later or even may precede the onset of the demyelinating disorders. The pathophysiology of movement disorders in demyelination is complex and the current evidence indicates a wide involvement of different brain networks and spinal cord. Treatment is mainly symptomatic and oral pharmacological agents are the mainstay of the management. Botulinum toxin and neurosurgical interventions may be required in selected patients.

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Subclinical Saccadic Eye Movement Dysfunction in Pediatric Multiple Sclerosis

Cited by 8 publications

References 23 publications

Remote telemedicine technologies in pediatric neurology.

Remote telemedicine technologies in pediatric neurology.

Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders

Movement Disorder in Demyelinating Disease

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