Subclinical small-intestinal disease in East Pakistan.

Lindenbaum, John; Alam, Athar; Kent, Thomas H.

doi:10.1136/bmj.2.5530.1616

Cited by 87 publications

(27 citation statements)

References 17 publications

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“…The abnormalities were observed under the dissecting microscope as leaves, ridges, or convoluted villi and under the light microscope as blunted, shortened villi with hypercellularity of the lamina propria. Subsequently, this observation has been confirmed by other investigators working in different areas in the tropics (Barker et al, 1962;Banwell et al, 1964;England and O'Brien, 1966;Jeejebhoy et al, 1966;Klipstein et al, 1966;Lindenbaum et al, 1966a;Russel et al, 1966). In addition to the instances cited, similar reports have emerged from more recent studies carried out in Vietnam (Colwell et al, 1968) and Mexico (Garcia, 1968).…”

Section: Occurrence Of Intestinal Abnormalitiessupporting

confidence: 55%

Present Status of Subclinical Intestinal Malabsorption in the Tropics

Falaiye¹

1971

BMJ

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Section: Occurrence Of Intestinal Abnormalitiessupporting

confidence: 55%

Present Status of Subclinical Intestinal Malabsorption in the Tropics

Falaiye¹

1971

BMJ

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“…These findings are in accordance with recent reports on the proximal small bowel morphology during acute enteritis. Chuttani, Jain, and Misra (1971) in their study of 22 patients with typhoid fever found only minor mononuclear cell infiltration in eight patients, an abnormality frequently seen in populations of the tropics (Russell, Aziz, Ahmad, Kent, and Gangarosa, 1966;Lindenbaum, Alam, and Kent, 1966). Sprinz, Gangarosa, Williams, Hornick, and Woodward (1966) in their study of experimental human typhoid fever found a granulomatous enteritis in small-bowel biopsies obtained shortly after challenge.…”

Section: Discussionmentioning

confidence: 97%

Immunoglobulin-containing cells in the small intestine during acute enteritis

Söltoft¹,

Söeberg²

1972

Gut

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SUMMARY Jejunal mucosal biopsies were obtained from 13 patients with acute enteritis. Ten patients were examined again after recovery. Quantitative analysis of the findings in immunofluorescence microscopy showed a significant increase of IgA-and IgM-containing cells during acute enteritis. After recovery the number of immunoglobulin-containing cells and their distribution within the different immunoglobulin classes were within normal limits.The lamina propria of the gastrointestinal tract is richly endowed with immunoglobulin-containing cells. These are considered to participate in local immune defence and to produce the major part of the immunoglobulins found in external secretion.To assess the influence of naturally occurring antigen stimulation on the immunoglobulin-containing cells of the human intestine the following study was carried out. Jejunal biopsies from patients with acute enteritis were obtained during the acute period and afterrecovery and the number of immunoglobulin-containing cells and theirdistribution on the different immunoglobulin classes were quantitated. MaterialThirteen patients, who were aged 17 to 70 years (median 39 years), with acute enteritis, all had fever and at least 15 watery, malodorous bowel movements a day without blood contamination. The diarrhoea persisted for five to 22 days (median eight days) and was the primary cause of hospital admission. In four cases salmonellae were cultured from the stools but in the remaining cases repeated bacteriological examinations were negative. All the patients were living in Denmark but eight had encountered the disease during tourist travel in southern Europe. None had previously had gastrointestinal complaints. except two who had had the gallbladder removed some years before because of gallstones. All patients 'Requests for reprints should be addressed to: J.

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“…A minority have malabsorption of two unrelated substances and some have recurrent diarrhoea (Lindenbaum et al, 1966a;Lindenbaum et al, 1966b;Klipstein et al, 1972;Baker and Mathan, 1972). It is recognised throughout the developing world, particularly in the tropics.…”

mentioning

confidence: 99%

“…Detailed reports have come from the Indian subcontinent (Lindenbaum et al, 1966a;Baker and Mathan, 1972), South East Asia (Sprinz et al, 1962;Colwell et al, 1968), the Caribbean (Klipstein et al, 1968;Klipstein et al, 1972), Mexico (Garcia, 1968), the Middle East (Parkins et al, 1966;Halsted et al, 1969), and parts of Africa (Banwell et al, 1964;Cook et al, 1969;Falaiye, 1971;Rhodes et al, 1971;Lindenbaum et al, 1972;Cook et al, 1973).…”

mentioning

confidence: 99%

Tropical enteropathy in Rhodesia.

Thomas¹,

Clain²,

Wicks³

1976

Gut

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SUMMARY Tropical enteropathy, which may be related to tropical sprue, has been described in many developing countries including parts of Africa. The jejunal changes of enteropathy are seen in Rhodesians of all social and racial categories. Xylose excretion, however, is related to socioeconomic status, but not race. Upper socioeconomic Africans and Europeans excrete significantly more xylose than lower socioeconomic Africans. Vitamin B12 and fat absorption are normal, suggesting predominant involvement of the proximal small intestine. Tropical enteropathy in Rhodesia is similar to that seen in Nigeria but is associated with less malabsorption than is found in the Caribbean, the

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Subclinical small-intestinal disease in East Pakistan.

Cited by 87 publications

References 17 publications

Present Status of Subclinical Intestinal Malabsorption in the Tropics

Present Status of Subclinical Intestinal Malabsorption in the Tropics

Immunoglobulin-containing cells in the small intestine during acute enteritis

Tropical enteropathy in Rhodesia.

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