Subclinical target organ damage in subjects with different components of metabolic syndrome

Rotar, O.; Boyarinova, M.; Могучая, Е. В.; Kolesova, Ekaterina; Erina, Anastasya; Солнцев, В. Н.; Konradi, Alexandra; Shlyakhto, E. V.

doi:10.1080/10641963.2017.1384488

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…Earlier work has shown that Notch-1 knockdown increases PTEN protein levels [ 4 ], and PTEN can inhibit PI3K signaling through dephosphorylating PIP3 and producing phosphatidylinositol 4,5-bisphosphate [ 9 ]. However, the relationship between Notch-1 and PI3K signaling pathways in AS has not been investigated previously.…”

Section: Discussionmentioning

confidence: 99%

“…Atherosclerosis (AS) is a chronic inflammatory disease of the vascular wall, which contributes to high morbidity and mortality of cardiovascular diseases [1,2]. It is an arterial disease associated with multiple risk factors such as obesity, high-saturated fat diets, hypercholesterolemia, hypertension and aging [3][4][5]. During AS formation, inflammation-derived endothelial dysfunction is the first step, followed by the recruitment of inflammatory cells (macrophage and T cells), the degeneration of extracellular matrix, and the disruption of elastic lamina AGING and collagen networks, which weakens the arterial wall and ultimately results in the formation of atherosclerotic plaques [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Macrophage-specific deletion of Notch-1 induced M2 anti-inflammatory effect in atherosclerosis via activation of the PI3K-oxidative stress axis

Zhang,

Yue,

Zhao

et al. 2023

Aging

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Objective: Notch-1 signaling is significantly associated with the occurrence and development of atherosclerosis (AS). However, the molecular mechanisms underlying the specific deletion of Notch-1 in AS-associated macrophages are not fully understood. This study aimed to investigate the effects of Notch-1 in AS. Methods and Results: Tissue samples were obtained from atherosclerotic segments of human carotid arteries. Immunofluorescence staining showed that Notch-1 was significantly colocalized with macrophages (CD68+), and Notch-1 staining was increased in human vulnerable plaques. Notch-1 MAC-KO /ApoE −/− mice were generated in which Notch-1 was selectively inactivated in macrophages, and WT for littermate control mice (ApoE −/− /Notch-1 WT ). A control group was then established. All mice fed with a high-fat and Oil Red O, Movat, a-SMA, CD68, and Sirius red staining were used to evaluate the morphology. Specific deletion of Notch-1 in macrophages repressed the pathophysiology of AS. Immunofluorescent staining and Western blotting revealed that Notch-1 MAC-KO repressed M1 and M2 responses in AS. Here, GSEA revealed that Notch-1 activation and PI3K signaling were statistically significantly correlated with each other, and Notch-1 was involved in the regulation of the PI3K signaling pathway. In the in vitro experiments, the secretion of Arg-1 and exosomes was classified by peritoneal macrophages of Notch-1 MAC-KO /ApoE −/− and Notch-1 WT /ApoE −/− mice. Immunohistochemistry staining and Western blotting were used to measure the expression levels of Notch1,

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Macrophage-specific deletion of Notch-1 induced M2 anti-inflammatory effect in atherosclerosis via activation of the PI3K-oxidative stress axis

Zhang,

Yue,

Zhao

et al. 2023

Aging

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“…современные ультразвуковые методы исследования позволяют уже на догоспитальном этапе с высокой точностью диагностировать как доклинические изменения артерий, так и выраженные изменения, к примеру стеноз высокой степени, окклюзия, расслоение. согласно нашим данным, нестенозирующий атеросклероз имелся у 54,8%, атеросклеротическая бляшка в просвете сосудов -у 45,3% пациентов с аГ, что свидетельствует о важности выявления данных отклонений, поскольку субклинические маркеры лучше, чем факторы риска, прогнозируют риск, позволяют лучше классифици-ровать пациентов по степени риска и более обоснованно подойти к выбору профилактики и лечения [29].…”

Section: ðåçóëüòàòûunclassified

Problems of insufficient control of target blood pressure levels in the outpatient practice

Ларина

Fedorova

Михайлусова

et al. 2021

Terapevticheskii arkhiv

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Aim. Assessment of the frequency of reaching the target level of blood pressure (BP) and the factors affecting it in outpatients with arterial hypertension (AH). Materials and methods. An open, one-stage, comparative study involving 64 patients with hypertension and 47 without hypertension at the age of 40 to 59 years. All patients underwent physical examination, assessment of cardiovascular risk (CVR), 24-hour blood pressure monitoring (ABPM), echocardiography (ECHOCG), color duplex scanning of brachiocephalic arteries. Results. Patients with hypertension and comparison groups were comparable in age, sex, smoking, history of myocardial infarction. 1st degree of hypertension was present in 26.6%, 2nd in 40.6%, 3rd in 12.5% of patients. Obesity was detected in 24.3% of patients and all patients with obesity had AH. The SCORE score in individuals with hypertension was 4.94.5; in the comparison group, 2.32.6 (p0.001). Non-stenosing atherosclerosis was present in 54.8% and 88%, p=0.020, and atherosclerotic plaque in the vascular lumen was present in 45.3% and 12% of patients with and without hypertension, respectively (p0.001). 68.8% were constantly treated, and the target BP was reached in 31.3% of patients with hypertension. Male gender (OR 1.68; 95% CI 1.6828.49; p=0.007), obesity (OR 4.78; 95% CI 1.1420.29; p=0.033), concomitant pathology (OR 3.09; 95% CI 1.029.37; p=0.046) were negative, and dyslipidemia (OR 0.10; 95% CI 0.010.84; p=0.033) was positive, affecting the achievement of the target level of blood pressure. Conclusion. The target level of blood pressure was achieved in 31.3% of outpatients with hypertension, mainly in women. Among patients who did not reach the target level of blood pressure, men, individuals with high SSR and obesity predominated. Concomitant pathology and obesity are negative, and dyslipidemia was positively associated with the achievement of the target level of blood pressure, which must be taken into account when developing measures for prevention and treatment.

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Vascular aging phenotypes based on VaSerа-screening results in young people with hypertension: Place of connective tissue dysplasia

Евсевьева¹,

Ерёмин

Rostovtseva³

et al. 2021

Arter. gipertenz.

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Objective. To assess the occurrence of various vascular aging phenotypes among young people, depending on the level of blood pressure (BP) and in relation to risk factors (RF) and the presence of connective tissue dysplasia (CTD).Design and methods. In total, 250 young people (88 boys and 162 girls) aged from 18 to 25 years old were examined at the University Health Center. All the subjects were divided into tercile groups based on cardio-ankle vascular index (CAVI), determined by the VaSera-1500 (Fucuda Denshia, Japan). According to the latest expert recommendations the third tercile group corresponds to early vascular aging or EVA syndrome. The first tercile group corresponds to favorable vascular aging. We have analyzed the representation of various vascular phenotypes in individuals with elevated and normal BP, as well as the main RF and external signs of CTD in each of CAVI-tercile group. Data processing was performed using the software package “Statistica 10.0” (StatSoft Inc., USA).Results. Among young people with office hypertension and high normal BP, the EVA phenotype and phenotypes of normal and favorable vascular aging are equally distributed. In persons with office normal and elevated BP, vascular stiffness correlates with weight, body mass index and waist circumference (with the increase in arterial rigidity these indicators decrease). CTD is registered among subjects with severe vascular remodeling both in boys and girls.Conclusions. Our data indicate the feasibility of angiology screening for identification of vascular aging phenotypes as a part of preventive measures among young people, regardless of the level of initial office BP. This strategy strategy will contribute to a more differentiated identification of risk groups and more individualized preventive interventions based on vascular aging phenotypes.

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Subclinical target organ damage in subjects with different components of metabolic syndrome

Cited by 3 publications

References 28 publications

Macrophage-specific deletion of Notch-1 induced M2 anti-inflammatory effect in atherosclerosis via activation of the PI3K-oxidative stress axis

Macrophage-specific deletion of Notch-1 induced M2 anti-inflammatory effect in atherosclerosis via activation of the PI3K-oxidative stress axis

Problems of insufficient control of target blood pressure levels in the outpatient practice

Vascular aging phenotypes based on VaSerа-screening results in young people with hypertension: Place of connective tissue dysplasia

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