Subclinical tubular epithelium damage and acute kidney injury following allogeneic hematopoietic stem cell transplantation

Добронравов, В. А.; Smirnov, Kirill; Afanasyev, Boris; Galkina, Olga; Смирнов, А. В.

doi:10.18620/ctt-1866-8836-2016-5-4-8-14

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2019

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“…The evolving concept of evaluating comorbidities during HSCT is to identify subclinical organ dysfunctions, which cannot be evaluated by means of HCT-CI index. The most progress in this area has been reached in evaluation and prediction of acute kidney injury and cardiotoxicity using highly sensitive biomarkers [12,13]. However, currently there are not such biomarkers for detection of subclinical lung injury in the context of HSCT [14].…”

Section: Introductionmentioning

confidence: 99%

Clinical features and prognostic value of functional disorders and pulmonary comorbidity in adult patients prior to allogeneic hematopoietic stem cell transplantation

Кулагин¹,

Волкова²,

Nikolaev³

et al. 2019

CTT

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High efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a wide range of malignant and non-malignant hematopoietic disorders system is limited to the risk of serious complications and non-relapse mortality (NRM). Pre-existing comorbidities before allo-HSCT are among key factors for NRM. The purpose of this study was to characterize the potential pre-transplant factors of pulmonary comorbidity and integral indicators of pulmonary function tests (PFT) and to evaluate their prognostic value for the allo-HSCT outcomes in adult patients.

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Section: Introductionmentioning

confidence: 99%