Subconjunctival Masses Associated With Central Nervous System Rosai–Dorfman Disease

Cavuoto, Kara M.; Dubovy, Sander R.; Gregori, Ninel Z.; McCarthy, Micheline

doi:10.1097/ico.0b013e3181e4570c

Cited by 14 publications

(5 citation statements)

References 10 publications

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Section: Discussionmentioning

confidence: 99%

“…In this location, adult male predominance was noted; multiple subconjunctival lesions and bilateral affection were commonly accompanied by other nodal and extranodal sites of disease. 7,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Clinical presentation of ophthalmic RDD is non-specific; and it is associated to the site of involvement. The main clinical manifestation in our patients was a painless soft tissue mass causing proptosis in orbit and foreign body sensation when located in conjunctiva.…”

Section: Discussionmentioning

confidence: 99%

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Rosai-Dorfman Disease involving the eye and ocular adnexa. Clinicopathologic series of 17 patients

Valles-Valles

Rodríguez-Reyes

Rodríguez-Martínez

et al. 2022

European Journal of Ophthalmology

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Purpose To describe the clinical features and histopathologic findings of Rosai-Dorfman disease (RDD) with ophthalmic involvement diagnosed at a Mexican ophthalmologic referral center in a period of 62 years. Results A total of 17 cases of RDD with ophthalmologic manifestations in Mexican-mestizo patients were collected. Female predominance was observed in 12 of 17 patients. The mean age was 36 years with a range of 12–76 years. The median age at presentation was 32 years. The orbit was the most affected location with 15 cases. Conjunctival disease was seen in 4 cases: two as isolated lesions, the rest with orbital or uveal involvement . One case suggested choroidal RDD associated to conjunctival and orbital lesion. Three cases presented multifocal disease. A patient with orbital affection developed extranodal disease elsewhere. No concurrent lymphadenopathy was observed in any patient. Histopathological examination revealed classic RDD findings in all cases: A polymorphous cellular infiltrate composed by lymphocytes, plasma cells and large histiocytes with emperipolesis hallmark of the disease. Immunohistochemically, histiocytes were positive for S-100 protein and CD68 in 15 cases. Conclusion RDD of the eye and ocular adnexa in Mexican-mestizo patients is common in middle-aged women frequently as an isolated orbital lesion. Histopathology is necessary for accurate diagnosis. Most patients had a favourable outcome after medical and surgical treatment. To the best of our knowledge this is the largest case series of RDD of the eye and ocular adnexa in Latin-American patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman Disease involving the eye and ocular adnexa. Clinicopathologic series of 17 patients

Valles-Valles

Rodríguez-Reyes

Rodríguez-Martínez

et al. 2022

European Journal of Ophthalmology

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“…According to 285 RDD literature reviewed cases [1][2][3][4][5]7,9,10,[12][13][14][15][16][17][18][19][20][21][22][23][24][26][27][28][29][30][31][32][33][34][35][36][37][38][39]41,[44][45][46][47][48][50][51][52][53][54][56][57][58][59][60][61][62]…”

Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman disease mimicking images of meningiomas: Two case reports and literature review

Tatit

Raffa²,

Motta

et al. 2021

Surgical Neurology International

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Background: Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytic proliferative disorder classically as a massive cervical lymphadenopathy. However, over the years, extranodal locations were confirmed with the central nervous system involvement in less than 5% of cases, which is marked as a significant differential diagnosis of meningiomas, with which they are widely confused due to the similarity of their radiological images. Case Description: We report a 37-year-old man and 45-year-old man who were diagnosed with intracranial RDD but whose radiological images mimic meningiomas, requiring anatomopathological and tumor’s immunohistochemistry for definitive diagnosis. Moreover, a review of 184 publications with 285 cases of intracranial involvement of this disease was also performed, comparing these findings with those brought in the previous studies. Conclusion: Intracranial Rosai-Dorfman tumors should always be remembered as differential diagnosis of meningiomas since they are similar radiologically and macroscopically. Once remembered and diagnosed, the lesion must be treated following the same pattern of resection done in meningiomas and, treatment’s differences will not occur in the surgical excision technique, but in complementary chemotherapy implementation, radiotherapy, and even with radiosurgery aid, depending on the case. Thus, it is possible to obtain better results than with just the isolated surgical procedure.

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“…In the present case, the mass (RDD) extended to the retrobulbar region and has encircled both optic nerves causing compression and complete blindness. Other reported cases have shown that optic nerve compression due to RDD may be unilateral [ 13 , 14 ] or bilateral [ 15 ]. Visual impairment is usually partial [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Isolated Intracranial Rosai-Dorfman Disease

Taufiq

Khair

Begum

et al. 2016

Case Reports in Neurological Medicine

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Background. Rosai-Dorfman disease (RDD) is a benign histiocytic proliferative disorder of unknown etiology. This rare condition commonly causes massive cervical lymphadenopathy. Intracranial RDD without any nodal involvement is extremely rare. Case Report. A young Bangladeshi male complained of bilateral complete blindness with left sided deafness for about three years. There was no lymphadenopathy. MRI and CT scan of brain suggested an inflammatory/neoplastic (?meningioma) lesion located at left parasellar region which extended frontally to encircle both optic nerves and also to left prepontine area. Histopathologically the lesion was diagnosed as RDD. The patient was treated with steroid and significant clinical improvement observed. Conclusion. The prognosis of intracranial RDD is not poor. It can be treated with surgery with or without corticosteroids, chemotherapy, and so forth. But as the condition is extremely rare and often misdiagnosed, the clinician, radiologist, and histopathologist should have a suspicion in their mind about the possibility of RDD.

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Subconjunctival Masses Associated With Central Nervous System Rosai–Dorfman Disease

Abstract: The authors present a case of extensive extranodal involvement of Rosai-Dorfman of the eye and the central nervous system.

Cited by 14 publications

References 10 publications

Rosai-Dorfman Disease involving the eye and ocular adnexa. Clinicopathologic series of 17 patients

Rosai-Dorfman Disease involving the eye and ocular adnexa. Clinicopathologic series of 17 patients

Rosai-Dorfman disease mimicking images of meningiomas: Two case reports and literature review

Isolated Intracranial Rosai-Dorfman Disease

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