and serum tests for circulating autoantibodies. A histopathological examination (HPE) of skin lesions, routinely stained with haematoxylin and eosin (H + E), although unable to detect crucial pathologic autoimmune phenomena, may reveal features suggestive of pemphigus, especially when assessed by an experienced dermatopathologist [3]. Due to the limited repertoire of microscopic patterns available for inflammatory dermatoses, a close, mutual collaboration between the clinician and the pathologist is required in order to make a precise diagnosis. Hence the concept of an international dermatopathological special-AbstrAct Introduction: Diagnosing autoimmune blistering diseases is based on clinical presentation and direct immunofluorescence detection of circulating autoantibodies. However, a histopathological examination of the affected tissues may also be helpful in such a diagnosis. Objective: To present a case illustrating that a histopathological examination facilitates the diagnosis of autoimmune blistering diseases, particularly for a patient with concomitant dermatological conditions. Case report: We present the case of a 91-year-old female patient with symptoms of generalized scaly, crusted erosions on an erythematosus base, who was diagnosed with psoriasis 10 years earlier. Based on a histopathological examination, there was a suspicion of pemphigus foliaceus, which was later confirmed by direct immunofluorescence and the multiparametric ELISA. Conclusions: A histopathological examination is not obligatory for a pemphigus diagnosis; however, in ambiguous cases, where a patient has other concomitant dermatoses, it may significantly improve the accuracy of the diagnosis. The limitations and advantages of histopathological examinations in pemphigus are discussed.