Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression

Lawrence, Natalia; Williams, A. Mark; Surguladze, Simon; Giampietro, Vincent; Brammer, Michael; Andrew, Christopher; Frangou, Sophia; Ecker, Christine; Phillips, Mary L.

doi:10.1016/j.biopsych.2003.11.017

Cited by 520 publications

(521 citation statements)

References 56 publications

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“…However, evidence here indicates left rather than right orbitofrontal and prefrontal areas (e.g., Lawrence et al, 2004;Altshuler et al, 2008). Specifically, Altshuler et al (2008) found reduced left orbitofrontal activation in depressive BD patients compared to healthy controls in a match facial emotion task using neutral and negative expressions.…”

Section: Introductionmentioning

confidence: 50%

“…Specifically, Altshuler et al (2008) found reduced left orbitofrontal activation in depressive BD patients compared to healthy controls in a match facial emotion task using neutral and negative expressions. Decreased activation in left dorsolateral prefrontal cortex has also been found in depressive BD patients for the perception of sad facial expressions (Lawrence et al, 2004). In line with these findings an electrophysiological study by Allen et al (1993), found higher right than left frontal activation in depressive BD patients compared to healthy controls.…”

Section: Introductionmentioning

confidence: 62%

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Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Najt

Hausmann

2014

Psychiatry Research

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Section: Introductionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 62%

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Najt

Hausmann

2014

Psychiatry Research

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“…* indicates po0.05 (two-tailed, unpaired t-test after Bonferroni correction). a 2C -Adrenoreceptor gene polymorphism and depression A Neumeister et al previous functional imaging studies in MDD patients studied during a spontaneous episode of MDD (Fu et al, 2004;Lawrence et al, 2004;Drevets et al, 2001). In contrast, the findings in the left ventral striatum in remitted MDD cases are opposite in direction to those reported in currently depressed MDD subjects by Fu et al (2004).…”

Section: Discussionmentioning

confidence: 99%

Effects of a α2C-Adrenoreceptor Gene Polymorphism on Neural Responses to Facial Expressions in Depression

Neumeister

Drevets

Belfer

et al. 2006

Neuropsychopharmacol

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Alterations in processing of emotionally salient information have been reported in individuals with major depressive disorder (MDD). Evidence suggests a role for noradrenaline in the regulation of a cortico-limbic-striatal circuit that has also been implicated in the pathophysiology of MDD. Herein, we studied the physiological consequences of a common coding polymorphism of the gene for the a 2C -adrenoreceptor (AR) subtypeFthe deletion of four consecutive amino acids at codons 322-325 of the a2C-AR (a2CDel322-325-AR) in medication-free, remitted individuals with MDD (rMDD), and healthy control subjects. After injection of 10 mCi of H 2 15 O, positron emission tomography (PET) measures of neural activity were acquired while subjects were viewing unmasked sad, happy, and fearful faces. The neural responses to sad facial expressions were increased in the amygdala and decreased in the left ventral striatum in rMDD patients relative to healthy control subjects. Furthermore, we report that rMDD carriers of one or two copies of the a2CDel322-325-AR exhibit greater amygdala as well as pregenual and subgenual anterior cingulate gyrus neuronal activity in response to sad faces than healthy a2CDel322-325-AR carriers and rMDD noncarriers. These results suggest that the a2CDel322-325-AR confers a change in brain function implicating this a2-AR subtype into the pathophysiology of MDD.

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“…Previous imaging studies using emotional face stimuli have also shown activation of medial and orbital prefrontal cortices, including anterior cingulate, insula and regions of the occipital cortex, particularly the fusiform gyrus (Sprengelmeyer et al, 1998;Blair et al, 1999;Surguladze et al, 2003;Abel et al, 2003;Keightley et al, 2003). Depressed and anxious patients have been shown to have altered neural responses to negative emotional faces (Lawrence et al, 2004;Thomas et al, 2001;Sheline et al, 2001). Antidepressant treatment has been shown to normalize increased amgydala responses to fearful faces in depressed patients (Sheline et al, 2001;Fu et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Citalopram Pretreatment on Neuronal Responses to Neuropsychological Tasks in Normal Volunteers: An fMRI Study

Del-Ben

Deakin

McKie

et al. 2005

Neuropsychopharmacol

239

184

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Changes in serotonin neurotransmission have also been implicated in the etiology and treatment of impulse control disorders, depression, and anxiety. We have investigated the effect of enhancing serotonin function on fundamental brain processes that we have proposed are abnormal in these disorders. In all, 12 male volunteers received citalopram (7.5 mg intravenously) and placebo pretreatment in a single-blind crossover design before undertaking Go/No-go, Loss/No-loss, and covert (aversive) face emotion recognition tasks during functional magnetic resonance imaging (fMRI). Blood oxygenation level dependent responses were analyzed using Statistical Parametric Mapping (SPM2). The tasks activated prefrontal and subcortical regions generally consistent with literature with lateral orbitofrontal cortex (BA47) common to the three tasks. Citalopram pretreatment enhanced the right BA47 responses to the No-go condition, but attenuated this response to aversive faces. Attenuations were seen following citalopram in the medial orbitofrontal (BA11) responses to the No-go and No-loss (ie relative reward compared with Loss) conditions. The right amygdala response to aversive faces was attenuated by citalopram. These results support the involvement of serotonin in modulating basic processes involved in psychiatric disorders but argue for a process-specific, rather than general effect. The technique of combining drug challenge with fMRI (pharmacoMRI) has promise for investigating human psychiatric disorders.

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Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression

Cited by 520 publications

References 56 publications

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Effects of a α2C-Adrenoreceptor Gene Polymorphism on Neural Responses to Facial Expressions in Depression

The Effect of Citalopram Pretreatment on Neuronal Responses to Neuropsychological Tasks in Normal Volunteers: An fMRI Study

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