Subcortical Aphasia

Radanovic, Márcia; Almeida, Victor N.

doi:10.1007/s11910-021-01156-5

Cited by 17 publications

(12 citation statements)

References 137 publications

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“…Aphasia refers to acquired language dysfunction, that is, the acquired language ability. Due to the language processing disorder caused by the brain damage of language function, the ability to understand and form language is impaired [ 5 ]. Aphasia patients can have various language or speech disorders, most of which are limited or even lost in spontaneous language, naming, retelling, reading, writing, and understanding.…”

Section: Introductionmentioning

confidence: 99%

The Progress of Functional Magnetic Resonance Imaging in Patients with Poststroke Aphasia

Tie

Xiang

Xia

2022

Journal of Healthcare Engineering

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Aphasia after stroke is one of the common complications of cerebral infarction. Early diagnosis and treatment of aphasia after stroke is of great significance for the recovery of language function. At present, there are different views on the pathogenesis of aphasia after stroke. Functional magnetic resonance imaging (fMRI) can reflect the brain function, brain tissue metabolism, and the level of brain local blood flow. It has the advantages of noninvasive, high resolution and sensitivity, low price, and so on. It has been widely used in the study of sensory aphasia after stroke. This study focuses on the development of functional magnetic resonance imaging in patients with poststroke aphasia and summarizes the published studies on functional magnetic resonance imaging in patients with poststroke aphasia. Evidence acquisition: A literature search was conducted in PubMed, Hindawi, PLoS, IEEE, Wiley, ScienceDirect, Springer, EMBASE, and web of science, with the keywords of “stroke” and “Aphasia” and “functional magnetic resonance imaging”, “RS fMRI”, or “DTI”, to review the research of functional magnetic resonance imaging in patients with aphasia after stroke. The results included clinical evaluation, diagnostic scale, and imaging analysis; the study design was a randomized controlled trial, case series and case report, and observational study. A total of 67 articles were identified in the first search and 43 after the second search. Based on the analysis of 43 selected articles, 19 articles were included, and 24 articles were excluded. The selected information is shown in Table 1. Eleven of them did not contain imaging-related data. Six articles are related review articles. Four studies were conducted on patients without poststroke aphasia. Three studies studied the effect of poststroke aphasia on patients’ social participation.

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Section: Introductionmentioning

confidence: 99%

The Progress of Functional Magnetic Resonance Imaging in Patients with Poststroke Aphasia

Tie

Xiang

Xia

2022

Journal of Healthcare Engineering

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“…Since aphasia and spatial neglect in humans are caused by damage to somewhat homologue networks in opposing hemispheres, the state of research on aphasia following subcortical grey matter lesions might help to put our current findings into context. Aphasia after basal ganglia damage in the left hemisphere also remains controversial with heterogeneous findings and a lack of consensus on the involvement of specific structures 53 . In line with the assumption of parallel mechanisms when considering our current results, white matter damage was found to be a potential explanation for the occurrence of aphasia in subcortical stroke 54,55 .…”

Section: Discussionmentioning

confidence: 99%

Spatial neglect after subcortical stroke: sometimes a cortico-cortical disconnection syndrome

Sperber,

Rosenzopf,

Wawrzyniak

et al. 2024

Preprint

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Background and Objectives: Spatial neglect is commonly attributed to lesions of a predominantly right-hemispheric cortical network. Although spatial neglect was also repeatedly observed after lesions to the basal ganglia and the thalamus, many anatomical network models omit these structures. We investigated if disruption of functional or structural connectivity can explain spatial neglect in subcortical stroke. Methods: We retrospectively investigated data of first-ever, acute stroke patients with right sided lesions of the basal ganglia (n = 27) or the thalamus (n = 16). Based on lesion location, we estimated i) functional connectivity via lesion-network mapping with normative resting state fMRI data, ii) structural white matter disconnection and iii) tract-wise disconnection of association fibres based on normative tractography data to investigate the association of spatial neglect and disconnection measures. Results: Apart from very small clusters of functional disconnection observed in inferior/middle frontal regions in lesion-network symptom mapping for basal ganglia lesions, our analyses found no evidence of functional or structural subcortico-cortical disconnection. Instead, the multivariate consideration of lesion load to several association fibres predicted the occurrence of spatial neglect (p = 0.0048; AUC = 0.76), which were the superior longitudinal fasciculus, inferior occipitofrontal fasciculus, superior occipitofrontal fasciculus, and the uncinate fasciculus. Conclusion: Disconnection of long (cortico-cortical) association fibres can explain spatial neglect in subcortical stroke. Like the competing theory of remote cortical hypoperfusion, this mechanism does not require the assumption of a genuine role for subcortical grey matter structures in spatial neglect.

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“…The patient in this case had aphasia because of a subcortical lesion. It has been reported that various symptoms, such as apraxia of speech, comprehension impairment, repetition impairment, naming impairment, and paraphasia, 21) are observed with subcortical lesions. There were several errors of no response, semantic paraphasia, and apraxia of speech in the TLPA, and language and speech impairments were observed in this case.…”

Section: Discussionmentioning

confidence: 99%

Constraint-induced Aphasia Therapy Improves the Use of Spoken Language and Word-finding Ability in Chronic Subcortical Aphasia: A Case Report

Takato¹,

Nanto

Kanamori³

et al. 2022

PRM

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Background: Constraint-induced aphasia therapy (CIAT) has been reported as a short-term, intensive language training program for improving language function in patients with chronic aphasia. We report the recovery of language function in a patient with chronic aphasia who was evaluated in the baseline assessment as having reached a plateau. Case: The patient with subcortical aphasia was a 62-year-old, right-handed man. At 192 days after left putamen hemorrhage, he visited our hospital to begin CIAT. The patient's language and speech abilities were evaluated 1 month before and immediately before the start of CIAT. To evaluate the training effect, language function was assessed immediately after, 1 month after, 3 months after, and 6 months after the end of CIAT. The Western Aphasia Battery (WAB), the single-word-naming task in the Test of Lexical Processing in Aphasia (TLPA), and the Verbal Activity Log (VAL) were used to assess his language function and the amount of spoken language. From 1 month before CIAT to 6 months after CIAT, the WAB Aphasia Quotient increased by 6.1 points. Compared with before therapy, the errors of apraxia of speech in the TLPA disappeared from immediately after to 6 months after CIAT. Although the VAL score at 3 months after CIAT was higher than that before the start of CIAT, the score decreased after 6 months because of reduced opportunities for communication with friends. Discussion: CIAT improved the word-naming ability and amount of spontaneous, real-world spoken language in a patient with chronic aphasia.

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Subcortical Aphasia

Cited by 17 publications

References 137 publications

The Progress of Functional Magnetic Resonance Imaging in Patients with Poststroke Aphasia

The Progress of Functional Magnetic Resonance Imaging in Patients with Poststroke Aphasia

Spatial neglect after subcortical stroke: sometimes a cortico-cortical disconnection syndrome

Constraint-induced Aphasia Therapy Improves the Use of Spoken Language and Word-finding Ability in Chronic Subcortical Aphasia: A Case Report

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