Subcortical Correlates of Craving in Recently Abstinent Alcoholic Patients

Schneider, Frank; Habel, Ute; Wagner, Michael; Franke, Petra; Salloum, Jasmin B.; Shah, N. Jon; Toni, Ivan; Sulzbach, Christian; Hönig, Klaus; Maier, Wolfgang; Gäebel, Wolfgang; Zilles, Karl

doi:10.1176/appi.ajp.158.7.1075

Cited by 298 publications

(240 citation statements)

References 35 publications

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“…From these findings, we conclude that axonal DAT-IR-enriched vermis lobules are activated by cocainerelated cues. The vermis also is activated during stimulant expectancy (Volkow et al, 2003) and in alcoholics during alcohol odor cue-induced craving (Schneider et al, 2001), implying that it may generally activate in response to drugassociated stimuli in drug abusing cohorts.…”

Section: Discussionmentioning

confidence: 99%

“…Acute administration of or cues for other stimulants or psychoactive drugs also has been associated with increased cerebellar activity (Volkow et al, 1996(Volkow et al, , 1988London et al, 1990;Ghatan et al, 1998;Sell et al, 1999;Domino et al, 2000). Two studies reported cerebellar midline (vermis) activation by alcohol odor cues and by stimulant expectancy (Schneider et al, 2001;Volkow et al, 2003). Such findings are intriguing in light of reports localizing DAT immunoreactivity (DAT-IR) and mRNA in primate cerebellar vermis (Melchitzky and Lewis, 2000;Hurley et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Cerebellar Vermis Involvement in Cocaine-Related Behaviors

Anderson

Maas

Frederick

et al. 2005

Neuropsychopharmacol

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Although the cerebellum is increasingly being viewed as a brain area involved in cognition, it typically is excluded from circuitry considered to mediate stimulant-associated behaviors since it is low in dopamine. Yet, the primate cerebellar vermis (lobules II-III and VIII-IX) has been reported to contain axonal dopamine transporter immunoreactivity (DAT-IR). We hypothesized that DAT-IR-containing vermis areas would be activated in cocaine abusers by cocaine-related cues and, in healthy humans, would accumulate DAT-selective ligands. We used BOLD fMRI to determine whether cocaine-related cues activated DAT-IR-enriched vermis regions in cocaine abusers and positron emission tomography imaging of healthy humans to determine whether the DAT-selective ligand [ 11 C]altropane accumulated in those vermis regions. Cocaine-related cues selectively induced BOLD activation in lobules II-III and VIII-IX in cocaine users, and, at early time points after ligand administration, we found appreciable [ 11 C]altropane accumulation in lobules VIII-IX, possibly indicating DAT presence in this region. These data suggest that parts of cerebellar vermis mediate cocaine's persisting and acute effects. In light of prior findings illustrating vermis connections to midbrain dopamine cell body regions, established roles for the vermis as a locus of sensorimotor integration and motor planning, and findings of increased vermis activation in substance abusers during reward-related and other cognitive tasks, we propose that the vermis be considered one of the structures involved in cocaine-and other incentive-related behaviors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cerebellar Vermis Involvement in Cocaine-Related Behaviors

Anderson

Maas

Frederick

et al. 2005

Neuropsychopharmacol

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“…In einer Studie zeigten detoxifizierte Alkoholpatienten Cravingphänomene bei der Präsentation alkoholassoziierter Reize, was im fM-RI mit einer Aktivierung der Amygdala einherging. Die Kontrollgruppe dagegen zeigte keinerlei derartige Veränderungen [45]. Nach 3-wöchiger Verhaltenstherapie und Gabe von Antidepressiva zeigten die Testpersonen ein deutlich gesenktes Craving.…”

Section: Oxytocin Im Einsatz Gegen Suchtmechanismenunclassified

“…Nach 3-wöchiger Verhaltenstherapie und Gabe von Antidepressiva zeigten die Testpersonen ein deutlich gesenktes Craving. Die Amygdalaaktivität im fMRI war nun nicht mehr abweichend von der Aktivität der Kontrollpersonen [45]. Diese Befunde unterstreichen die These, dass die Beeinflussung von Stress und die Senkung der CRF-Aktivität in der Amygdala durch Oxytocin zielführend sein könnten.…”

Section: Oxytocin Im Einsatz Gegen Suchtmechanismenunclassified

Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit

2017

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Oxytocin and the mechanisms of alcohol dependenceSummary One of the crucial purposes of treating alcohol-dependent patients is to enhance their ability to stay abstinent after detoxification therapy. Anxiety and stress vulnerability are the main factors provoking alcohol craving and relapse. In the first months of abstinence, alcohol-dependent patients frequently show sleep disturbances, irritability and depression, indicating chronic activation of stress pathways. In addition, the loss of confidence in interpersonal interactions results in social withdrawal and reduced willingness to participate in therapeutic programs. Current research shows that the peptide hormone oxytocin exerts substantial anxiolytic effects and facilitates prosocial behavior. Oxytocin can be safely ap-K

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“…Furthermore, this work demonstrated that taste and visual cues could induce brain activation in alcoholics within the MRI environment. Two subsequent studies have utilized fMRI with visual (Braus et al, 2001) or olfactory (Schneider et al, 2001) cues. These studies found activation of the putamen as well as the subcortical-limbic region and cerebellum, respectively.…”

Section: Introductionmentioning

confidence: 99%

Differential Brain Activity in Alcoholics and Social Drinkers to Alcohol Cues: Relationship to Craving

Myrick

Anton

et al. 2003

Neuropsychopharmacol

473

345

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Using fMRI, our group previously found that after a sip of alcohol and exposure to alcohol beverage pictures, alcoholics compared to social drinkers had increased differential brain activity in the prefrontal cortex and anterior thalamus. This study extends this earlier work with several improvements including imaging the entire brain (rather than the anterior half previously) and recording craving, while the subjects viewed images within the scanner. In a Philips 1.5 T MRI scanner, 10 nontreatment-seeking alcoholics and 10 age-matched healthy social drinkers were given a sip of alcohol before viewing a 12 min randomized presentation of pictures of alcoholic beverages, nonalcoholic beverages, and two different visual control tasks. During picture presentation, changes in regional brain activity were measured in 15 transverse T2*-weighted blood oxygen level dependent slices. Subjects rated their urge to drink after each picture sequence. After a sip of alcohol, while viewing alcohol cues compared to viewing other beverage cues, the alcoholics, but not social drinkers, reported higher craving ratings and had increased activity in the prefrontal cortex and anterior limbic regions. Brain activity in the left nucleus accumbens, anterior cingulate, and left orbitofrontal cortex significantly correlated with subjective craving ratings in alcohol subjects but not in control subjects. This study suggests, as did our earlier study, that alcoholics and not social drinkers, when exposed to alcohol cues, have increased brain activity in areas that reportedly subserve craving for other addictive substances.

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Subcortical Correlates of Craving in Recently Abstinent Alcoholic Patients

Abstract: This investigation points to state-dependent neurobiological correlates of cue-induced craving in alcoholic patients and suggests that these correlates can be influenced by therapeutic interventions. The presence of emotional aspects of craving is suggested by amygdala activation.

Cited by 298 publications

References 35 publications

Cerebellar Vermis Involvement in Cocaine-Related Behaviors

Cerebellar Vermis Involvement in Cocaine-Related Behaviors

Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit

Differential Brain Activity in Alcoholics and Social Drinkers to Alcohol Cues: Relationship to Craving

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