Subcritical water extraction of fucoidan from Saccharina japonica: optimization, characterization and biological studies

Saravana, Periaswamy Sivagnanam; Tilahun, Adane; Gerenew, Collin; Tri, Vo Dinh; Kim, Nan Hee; Kim, Gun‐Do; Woo, Hee-Chul; Chun, Byung‐Soo

doi:10.1007/s10811-017-1245-9

Cited by 77 publications

(67 citation statements)

References 46 publications

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“…Likewise, fucoidan yield from N. zanardinii obtained by PLE under optimized conditions (29 min, 150 • C, water to sample ratio of 21 mL/g and pressure of 7.5 bar) was 25.98% which was considerably higher than 5.2% obtained by CE [87]. Saravana et al [85] achieved almost 2 times higher fucoidan yield from Saccharina japonica by PLE under optimized conditions (11.98 min, 127.01 • C, 80 bar and 0.04 g/mL) than by CE, while S. japonica extraction yield was more than 4-times higher by PLE (140 • C, 50 bar) with 0.1% NaOH as a solvent compared to 0.05M HCl CE [82]. Even though PLE caused lower APS sulfate content in comparison to HWE, MAE and EAE [64], sulfate content achieved by using PLE with 0.1M NaOH as solvent was almost 2-folds higher than in CE [85].…”

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 80%

“…In both of these studies uronic acid and fucose content were higher, while galactose and glucose content obtained by PLE were lower. Additionally, Saravana et al [85] obtained higher total sugar, protein and phenolic content by PLE, meaning that besides improved yield impurities were also increased. Polysaccharides obtained by PLE had lower MW and higher polydispersity [64,82,85].…”

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 98%

“…Additionally, Saravana et al [85] obtained higher total sugar, protein and phenolic content by PLE, meaning that besides improved yield impurities were also increased. Polysaccharides obtained by PLE had lower MW and higher polydispersity [64,82,85]. In contrast to polysaccharides obtained by CE, PLE extracted polysaccharides showed antibacterial activity and antiviral activity against HSV-2 infection [64].…”

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 98%

“…Depending on the solvent used for the extraction and its diverse working conditions, PLE is often called pressurized fluid extraction (PFE), pressurized solvent extraction (PSE), accelerated solvent extraction (ASE), subcritical water extraction (SWE) or hot water extraction (HWE) [80]. For polysaccharide extraction from brown algae different type of static [81] or dynamic [82][83][84][85] PLE equipment has been used. Commercial laboratory-scale equipment commonly used for PLE was developed by the Dionex Corporation in 1995 and it can only be operated in static (batch) mode while some in-house equipment can be used in dynamic mode (continuous flow) [86].…”

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 99%

“…Saravana et al [85] achieved almost 2 times higher fucoidan yield from Saccharina japonica by PLE under optimized conditions (11.98 min, 127.01 • C, 80 bar and 0.04 g/mL) than by CE, while S. japonica extraction yield was more than 4-times higher by PLE (140 • C, 50 bar) with 0.1% NaOH as a solvent compared to 0.05M HCl CE [82]. Even though PLE caused lower APS sulfate content in comparison to HWE, MAE and EAE [64], sulfate content achieved by using PLE with 0.1M NaOH as solvent was almost 2-folds higher than in CE [85]. In both of these studies uronic acid and fucose content were higher, while galactose and glucose content obtained by PLE were lower.…”

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 99%

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Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

et al. 2020

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Over the years, brown algae bioactive polysaccharides laminarin, alginate and fucoidan have been isolated and used in functional foods, cosmeceutical and pharmaceutical industries. The extraction process of these polysaccharides includes several complex and time-consuming steps and the correct adjustment of extraction parameters (e.g., time, temperature, power, pressure, solvent and sample to solvent ratio) greatly influences the yield, physical, chemical and biochemical properties as well as their biological activities. This review includes the most recent conventional procedures for brown algae polysaccharides extraction along with advanced extraction techniques (microwave-assisted extraction, ultrasound assisted extraction, pressurized liquid extraction and enzymes assisted extraction) which can effectively improve extraction process. The influence of these extraction techniques and their individual parameters on yield, chemical structure and biological activities from the most current literature is discussed, along with their potential for commercial applications as bioactive compounds and drug delivery systems.(APS) is determined by algae species however it is also influenced by other factors causing inter-species variation, e.g., growth location and harvesting season [8]. Vast structural variation between the APS therefore presents a challenge in terms of pre-treatments application, extraction techniques and optimization, characterization of isolated fractions and determination of their biological properties.Chemical structure and yield of APS isolated from marine macroalgae by conventional extraction (CE) techniques can be affected by various experimental conditions (pH, time, temperature, pressure, particle size, solvent, sample to solvent ratio, agitation speed etc.). In addition, different advanced techniques such as microwave assisted extraction (MAE), ultrasound assisted extraction (UAE), pressurized liquid extraction (PLE), enzyme-assisted extractions (EAE) are assessed and applied for APS extraction [9][10][11].In general, the chemical structure of polysaccharides determines its physical, chemical and biochemical properties as well as its biological activities [12]. Several studies have reported that their biological activity is strongly associated with their chemical structure [9]. Due to very complex mechanisms that are affected by many factors, the correlation between polysaccharide structure and biological activity is still not sufficiently clarified.In order to improve isolation of APS, pre-treatments are usually applied to the algal biomass prior to the extraction process with the two aims: (i) to prevent co-extraction of interfering bioactive compounds with similar solubility; and (ii) to disrupt cell walls and improve mass transfer of APS into extraction solvent. The first type of pre-treatments is therefore used to remove compounds which are highly bound to the APS such as proteins, phenols and lipids, as well as mannitol and chlorophyll [13]. For that purpose, the application of various pr...

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Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 80%

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 98%

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 98%

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 99%

Section: Pressurized Liquid Extraction (Ple)mentioning

confidence: 99%

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Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

et al. 2020

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Extraction Technologies for Bioactive Polysaccharides

Qari

Ravindran

2021

Recent Advances in Micro and Macroalgal Processing

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A critical review on extraction, characteristics, physicochemical activities, potential health benefits, and industrial applications of fucoidan

Zhao

Cheng

et al. 2022

eFood

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Fucoidan is a kind of sulfated polysaccharide that consists mainly of fucose and is found in marine brown alga. Fucoidan is a major bioactive compound in brown seaweeds known to have biological activities including anticancer, antiinflammatory, antioxidant, anticoagulant, antithrombotic, antivirus, hypolipidemic, and immune-modulating properties. Due to the adhesive property of fucoidan, it can increase endothelial cell adhesion and proliferation. An increasing number of investigations in the past few years have demonstrated the extraction process of fucoidan. However, the critical review of fucoidan in health benefits has been less explored. In this review, the recent advances of fucoidan were summarized. Moreover, the extraction and purification processes, the characterization of structure, as well as its physicochemical activities, biological activities, and industrial applications were discussed. This review will provide fundamental information for future investigation on controlling the structure, purity, and consistency of the fucoidan product.

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Subcritical water extraction of fucoidan from Saccharina japonica: optimization, characterization and biological studies

Cited by 77 publications

References 46 publications

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

Extraction Technologies for Bioactive Polysaccharides

A critical review on extraction, characteristics, physicochemical activities, potential health benefits, and industrial applications of fucoidan

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