Subcutaneous fat necrosis of the newborn: a systematic evaluation of risk factors, clinical manifestations, complications and outcome of 16 children

Mahé, E.; Girszyn, N.; Hadj‐Rabia, Smail; Bodemer, Christine; Hamel‐Teillac, Dominique; Prost, Y. De

doi:10.1111/j.1365-2133.2007.07782.x

Cited by 131 publications

(161 citation statements)

References 27 publications

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“…Subkutan yağ nekrozu genellikle zamanında doğ-muş bebeklerde yaşamın ilk haftalarında görülen sırt, yanak, omuz, kalça ve uyluklarda, eritematöz-mor renkli subkutan plak ve nodüllerle karakterize adipöz dokunun inflamatuvar bir hastalığıdır (1)(2)(3)(4)(5) . Sıklığı ve etiyopatogenezi tam olarak bilinmemekle birlikte, annedeki diabet ve preeklampsi gibi plasental perfüz-yonu bozan anne kaynaklı nedenler ile asfiksi, doğum travması ve terapötik hipotermi ile birlikteliği sık olarak bildirilmektedir.…”

Section: Discussionunclassified

“…Subkutan yağ nekrozu olan hastalarda ender olarak hipokalsemi görülmekte, genellikle hiperkalsemi eşlik etmektedir (1,4,5,7) . Yapılan bir çalışmada, lezyonların başlangıcından 10 gün sonra görülen hipokalseminin etiyolojisinde psödohipoparatiroidizm olduğu gösterilmiştir (5) .…”

Section: Discussionunclassified

“…Bu durum doğum asfiksisi olan genellikle term bebeklerde görülmektedir (1)(2)(3)(4) . Başlangıçta eritematöz renkte plakların görülmesinden sonra zaman içerisinde son derece sert, hassas derialtı nodülleri ortaya çıkar.…”

Section: Introductionunclassified

“…Başlangıçta eritematöz renkte plakların görülmesinden sonra zaman içerisinde son derece sert, hassas derialtı nodülleri ortaya çıkar. En ağır birliktelik hiperkalsemi ile olup, sıklıkla SYDN gelişiminden sonraki 6.-7. haftalarda gelişir (2)(3)(4)(5) . Burada asfiktik doğum öyküsü olan, hipotermi tedavisi uygulanan, hipokalsemi sonrasında hiperkalsemi ve nefrokalsinozis bulguları olan SYDN'lu zamanın-da doğan bir yenidoğan olgusu sunulmuştur.…”

Section: Introductionunclassified

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Subcutaneous Fat Necrosis Associated with hypo/Hypercalcemia and Brachiall Plexopathy

Yimenicioglu¹,

Yimenicioğlu²,

Türkeli³

et al. 2016

Buch

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ÖZSubkutan yağ nekrozu yaşamın ilk haftalarında görülen etiyolojisi tam olarak bilinmeyen ender bir hastalıktır. Gestasyonel diabet, preeklampsi, asfiksi, mekonyum aspirasyonu, doğum travması, sepsis ve hipotermi gibi perinatal komplikasyonların suçlandığı bir pannikülittir. Sırt, omuzlar, kalça ve uylukta yerleşen, kırmızı renkli, keskin sınırlı sıklıkla ağrısız nodüller ile karakterizedir. Bu olguda zamanında doğan, asfiktik doğum öyküsü olan, hipotermi tedavisi uygulanan, erken dönemde hipokalsemi daha sonra hiperkalsemi ve nefrokalsinozis gelişen 24 günlük yenidoğan bebekte subkutan yağ dokusu nekrozuna bağlı gelişebilecek metastatik kalsifikasyonların erken dönemde eşlik edebileceğinin vurgulanması açı-sından sunulmuştur.Anahtar kelimeler: Subkutan yağ nekrozu, asfiksi, hipokalsemi ABSTRACTSubcutaneous fat necrosis is a rare disorder, mostly seen at first week of life whose etiology is not truely known. It ıs panniculitis that perinatal complications like gestational diabetes, preeclampsia, asphyxia, meconium aspiration, birth trauma, sepsis and hypothermia are thought to be the causes. Subcutaneous fat necrosis is characterized by usually painless red-coloured nodular lesions with sharp contours localized on back, shoulders, hips, and thighs. In this case we decided to emphasize early development of metastatic calcifications secondary to subcutaneous fat necrosis at a 24 day-old term neonate with a history of neonatal asphyxia who had undergone treatment for hypothermia, and developed hypocalcemia, hypercalcemia, and finally nephrocalcinosis.

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Section: Discussionunclassified

Section: Introductionunclassified

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Subcutaneous Fat Necrosis Associated with hypo/Hypercalcemia and Brachiall Plexopathy

Yimenicioglu¹,

Yimenicioğlu²,

Türkeli³

et al. 2016

Buch

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“…1 and 2) 2. SCFN usually has a favorable prognosis, with complete autoresolution of subcutaneous lesions within several weeks or months, but it may also be complicated by serious metabolic alterations 3.…”

Section: Introductionmentioning

confidence: 99%

Subcutaneous fat necrosis of the newborn

Rubin

Spagnut

Morandi

et al. 2015

Clinical Case Reports

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Key Clinical MessageSubcutaneous fat necrosis (SCFN) is a rare fat tissue inflammation of the newborn. Risk factors include cord prolapse, perinatal asphyxia, therapeutic hypothermia, meconium aspiration, and sepsis. When present, hypercalcemia comes with lethargy, hypotonia, irritability, vomiting, polyuria, polydipsia, constipation, and dehydration. Kidney injury must be avoided. SCFN is often completely autoresolutive.

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Subcutaneous Fat Necrosis as a Complication of Whole-Body Cooling for Birth Asphyxia

Oza¹,

Treat²,

Cook³

et al. 2010

Arch Dermatol

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Background: Subcutaneous fat necrosis (SCFN) of the newborn is a form of panniculitis that affects full-term neonates who often have suffered either birth asphyxia or hypothermia. The induction of hypothermia in newborns is becoming frequently used to reduce the neurologic sequelae associated with birth asphyxia. The risk of SCFN in neonates undergoing this therapy is unknown.Observation: We describe a neonate who developed an abscesslike presentation of SCFN and subsequent asymp-tomatic hypercalcemia after undergoing whole-body cooling for hypoxic-ischemic encephalopathy.Conclusions: Hypothermia protocols may be placing newborns at increased risk for the development of SCFN. Clinicians should recognize this association, and newborns who undergo therapeutic cooling should have frequent dermatologic assessments.

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Subcutaneous fat necrosis of the newborn: a systematic evaluation of risk factors, clinical manifestations, complications and outcome of 16 children

Abstract: This study on 16 newborns with SFN provides new information. Familial or newborn risk factors for thrombosis are frequent. Macrosomia, familial dyslipidaemia and smoking should be evaluated. The main complications identified were severe pain, hypercalcaemia and subcutaneous atrophy.

Cited by 131 publications

References 27 publications

Subcutaneous Fat Necrosis Associated with hypo/Hypercalcemia and Brachiall Plexopathy

Subcutaneous Fat Necrosis Associated with hypo/Hypercalcemia and Brachiall Plexopathy

Subcutaneous fat necrosis of the newborn

Subcutaneous Fat Necrosis as a Complication of Whole-Body Cooling for Birth Asphyxia

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