Subcutaneous Fat Necrosis of the Newborn: Report of Five Cases

Lara, Leire González; Villa, Asunción Vicente; Rivas, María Mercedes Otero; Capella, Mariona Suñol; Prada, Fredy; Enseñat, María Antonia González

doi:10.1016/j.pedneo.2014.06.010

Cited by 24 publications

(43 citation statements)

References 11 publications

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“…Los diagnósticos diferenciales de la NGRN además de otras paniculitis del RN (esclerema neonatorum (EN), post esteroide y por frío) se encuentran: hemangioma, celulitis, histiocitosis, enfermedad de Faber, fibromatosis y rabdomiosarcomas que son histológicamente diferentes 17 .…”

Section: Discussionunclassified

Necrosis grasa del recién nacido

et al. 2020

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Introducción: Las paniculitis constituyen un grupo de enfermedades que afectan al tejido graso subcutáneo y se manifiestan clínicamente como nódulos. Su patogenia no es del todo clara, por lo general es asintomático. El diagnóstico confirmatorio es histológico.Objetivo: describir las características clínicas e histopatológicas de un caso de necrosis grasa, una forma especifica de paniculitis en el recién nacido (RN).Caso Clínico: RN femenino de 40 semanas, parto cesárea de urgencia por taquicardia fetal más meconio, APGAR 7-8-9. Requirió oxigeno y presión positiva por 5 min. Al quinto día de vida presentó aumento de volumen en tronco posterior, de coloración eritematosa - violácea, remitente a la palpación, no doloroso. Ecotomografría de piel y partes blandas informó aumento de la ecogenecidad del tejido celular subcutáneo y pérdida de definición de las celdillas adiposas de aproximadamente 42.3 x 9.7 x 20.1 mm, sin presencia de vascularización. Biopsia de piel: epidermis con acantosis irregular y ortoqueratosis en cestas; dermis papilar con infiltrado inflamatorio y dermis reticular y tejido adiposo con presencia de infiltrado linfohistocitiario con tendencia a la formación de nódulos, sin compromiso vascular, leves depósitos de colesterol; compatible con necrosis grasa del recién nacido (NGRN). Paciente tuvo regresión completa de la lesión a los tres meses de vida.Conclusiones: se describe un caso compatible clínica e histológicamente con NGRN; sin complicaciones durante su observación. Por lo general esta patología tiene buen pronóstico, con resolución espontánea, como en nuestro caso.

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Section: Discussionunclassified

Necrosis grasa del recién nacido

et al. 2020

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“…The etiology of hypertriglyceridemia in children includes (i) familial hypertriglyceridemia, an autosomal dominant condition that results from hepatic secretion of large VLDL particles that are triglyceride-rich; (ii) familial chylomicronemia syndrome, which is caused by defective lipoprotein lipase activity; (iii) fat necrosis, which may occur in infants undergoing therapeutic hypothermia; and (iv) iatrogenic causes such as the administration of intralipids [ 12 , 13 ]. When the history and biochemical findings are not consistent with any of these etiologies in a patient with elevated triglycerides, pseudohypertriglyceridemia secondary to glycerol kinase deficiency should be considered [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Pseudohypertriglyceridemia: A Novel Case with Important Clinical Implications

Rughani

Blick

Hui

et al. 2020

Case Reports in Pediatrics

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Pseudohypertriglyceridemia is an overestimation of serum triglyceride levels that may incorrectly lead to a diagnosis of hypertriglyceridemia. Glycerol kinase deficiency is a condition in which glycerol cannot be phosphorylated to glycerol-3-phosphate, resulting in elevated levels of serum glycerol. Laboratory assays that measure triglycerides indirectly may be affected by elevated glyerol levels and incorrectly report serum tryglyceride levels. We present a case of a novel missense mutation in the GK gene leading to isolated glycerol kinase deficiency and pseudohypertriglyceridemia in a male infant of a mother with gestational diabetes. This paper reviews glycerol kinase deficiency, describes the challenges in diagnosing pseudohypertriglyceridemia, and provides suggestions on improving diagnostic accuracy. Additionally, a potential maternal-fetal interaction between gestational diabetes and glycerol kinase deficiency is discussed.

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“…However, a few serious sequelae have been reported, which include hypercalcemia, hypoglycemia, hypertriglyceridemia, and thrombocytopenia. 1 , 3 - 5 , 7 Hypercalcemia, in particular, has been shown to be commonly associated with SCFN. It is proposed that granulomatous tissue in SCFN has the capacity to activate vitamin D 3 as well as produce extrarenal calcitriol, both of which lead to hypercalcemia.…”

Section: Discussionmentioning

confidence: 99%

Newborn With Enlarged Erythematous Mass on Back: Case Report and Review of Medical Literature

Aye

Mahaseth

Rozzelle

et al. 2018

Global Pediatric Health

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Newborn skin nodules are usually benign and self-resolving skin condition. Differential diagnosis of such lesions include cysts, hemangioma, abscess, cellulitis, sclerema neonatorum, subcutaneous fat necrosis, neurofibromatosis, benign tumors, or malignant tumors such as rhabdomyosarcoma, infantile fibrosarcoma, or neuroblastoma. We report a case of congenital subcutaneous fat necrosis in a 7-day-old baby presenting with multiple erythematous mass on back.

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Subcutaneous Fat Necrosis of the Newborn: Report of Five Cases

Cited by 24 publications

References 11 publications

Necrosis grasa del recién nacido

Necrosis grasa del recién nacido

Pseudohypertriglyceridemia: A Novel Case with Important Clinical Implications

Newborn With Enlarged Erythematous Mass on Back: Case Report and Review of Medical Literature

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