Subcutaneous fat necrosis of the newborn: clinical manifestations in two cases

Gomes, Milena Pires de Campos Luciano; Porro, Adriana María; Enokihara, Milvia Maria Simões da Silva; Floriano, Marcos C.

doi:10.1590/abd1806-4841.20132229

Cited by 24 publications

(47 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a case series conducted by Burden and Krafchik, 4 of 11 (36%) children diagnosed with subcutaneous fat necrosis developed hypercalcemia . Both Gomes et al and Woods and Cederholm state that hypercalcemia occurs in approximately 25% of reported cases . In a study by Mahe et al, 9 of 16 (56%) patients developed hypercalcemia, although only 13 of these patients were evaluated for laboratory abnormalities.…”

Section: Discussionmentioning

confidence: 99%

“…29 Both Gomes et al and Woods and Cederholm state that hypercalcemia occurs in approximately 25% of reported cases. 30,31 In a study by Mahe et al 32 , 9 of 16 (56%) patients developed hypercalcemia, although only 13 of these patients were evaluated for laboratory abnormalities. The incidence of hypercalcemia was found to be 51% in our study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature

Stefanko

Drolet

2018

Pediatric Dermatology

View full text Add to dashboard Cite

Subcutaneous fat necrosis of the newborn is an uncommon disorder, and although usually benign, associated hypercalcemia can lead to complications such as failure to thrive and renal failure. Many sources suggest screening for hypercalcemia for 6 months following resolution of skin lesions, but little data are available to support this recommendation. This study examines existing published literature to better guide practitioners regarding screening evaluations of asymptomatic patients with subcutaneous fat necrosis. A systematic review of the literature was conducted using a PubMed English literature search. Data from case reports and case series were collected regarding the presence of hypercalcemia and associated complications, birth history, and age of onset/resolution of skin lesions and laboratory abnormalities. Approximately half (51%) of infants reported had hypercalcemia. Most (77%) developed detectable hypercalcemia within 30 days of skin lesion onset, and 95% developed detectable hypercalcemia within 60 days of skin lesion onset. Hypercalcemia was detected in only 4% of patients > 70 days following onset of skin lesions. Seventy-six percent had resolution of hypercalcemia within 4 weeks of detection. Hypercalcemia was more prevalent in full-term vs pre-term infants (P-value = 0.054), and higher birthweight was significantly associated with an increased risk of developing hypercalcemia (P-value = 0.022). Although gestational age trended toward significance, the only statistically significant clinical feature predicting the development of hypercalcemia was higher birthweight. Current recommendations for laboratory monitoring are not evidence-based, and this study provides interim data to guide practitioners until prospective, randomized controlled trials are conducted.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature

Stefanko

Drolet

2018

Pediatric Dermatology

View full text Add to dashboard Cite

show abstract

“…Subcutaneous fat necrosis of the newborn (SCFN) represents a benign condition occurring in the neonatal period [4], characterized by inflammation and necrosis of subcutaneous fat tissue and typically presenting with subcutaneous purple-bluish hard nodules (see Figs. 1 and 2) [5]. Lesions may appear isolated or clustered and are typically located on shoulders, back, buttocks, and face [6]; nodules may evolve into subcutaneous calcifications [5].…”

Section: Discussionmentioning

confidence: 99%

“…1 and 2) [5]. Lesions may appear isolated or clustered and are typically located on shoulders, back, buttocks, and face [6]; nodules may evolve into subcutaneous calcifications [5].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation