Subcutaneous glucose monitoring with GlucoDay®: comparison of the results to those obtained with the Endocrine Artificial Pancreas

Abstract

ObJEctIVE: this study was undertaken to assess the accuracy of GlucoDay ® -a portable detector of subcutaneous glucose -by comparing the results to those obtained by biostator ® an established and reliable method for continuous glucose measurement in whole blood. DEsIGN: subjects with type 1 diabetes (n:6), subjects with type 2 diabetes (n:6), and six healthy controls were studied for 24 hours; they consumed three main meals. the GlucoDay ® was connected to the subjects by inserting a microfibre probe into the periumbilical subcutaneous area, whilst the biostator ® was inserted by a double-lumen catheter into an antecubital vein. A third catheter was inserted into a separate vein for blood withdrawal to measure glucose by the hexokinase method. rEsULts: the three methods (GlucoDay ® -biostator ® -hexokinase) were equally accurate in measuring glucose levels (p=0.233, Kruskall-Wallis test). the glucose measurements performed with GlucoDay ® and biostator ® were significantly correlated with those performed with hexokinase (p<0.001, r2=66.65% and p<0.001, r2=64.4%, respectively, using simple regression analysis). cONcLUsIONs: Measurements of glucose fluctuations in the subcutaneous tissue with the GlucoDay ® were close to those in blood determined by the biostator ® . GlucoDay® is therefore a reliable method for continuous glucose monitoring and may prove useful for optimizating treatment in patients with type 1 or type 2 diabetes.

Glucose biosensors for Diabetes Mellitus management

“…System (Product: GlucoDay) [12] Saliva Glucose Biosensor [8] The biosensor stick consists of the ceramic substrate and a platinum electrode. The stick is kept on the surface of the tongue and the information is wirelessly transmitted to the smart phone.…”