Subcutaneous Implantation of Female and Male Hormone in Tablet Form in Women

Loeser, Arnold

doi:10.1136/bmj.1.4133.479

Cited by 42 publications

(8 citation statements)

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“…Loeser reported that testosterone increased women's sexual libido [7]. This observation was further supported by studies reported by Greenblatt et al.…”

Section: Testosterone Therapy In Patients With Gynecological and Sexusupporting

confidence: 70%

“…The notion that androgens are integral to women's sexual physiology was supported by studies demonstrating the effect of androgens on women's libido and on sexual function for the past seven decades (Figure 1). Loeser found that patients (N = 10) given implantations of testosterone tablets (smallest dose, 300 mg) experienced an enlargement of the clitoris, an increase in libido, and a heightened sense of well‐being [7]. It should be noted that 300 mg was a very high dose for pellet implantation of testosterone in a woman.…”

Section: Androgen Therapy Of Sexual Dysfunctionmentioning

confidence: 99%

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Testosterone Therapy in Women with Gynecological and Sexual Disorders: A Triumph of Clinical Endocrinology from 1938 to 2008

Traish

Feeley

Guay

2009

The Journal of Sexual Medicine

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Introduction Although the term “medicalization” has been used by some to describe contemporary testosterone use in women with sexual disorders and testosterone deficiency syndrome, testosterone therapy for women with various gynecological and sexual disorders has been practiced since the late 1930s. Aim The study aimed to perform a historical review of testosterone use in women with sexual and gynecological disorders. This review is necessary to bridge important knowledge gaps in the clinical use of testosterone in women with sexual health concerns and to provoke new thoughts and understanding of the multidisciplinary role of testosterone in women’s overall health. Methods Review of medical literature on androgen therapy in women was carried out from 1938 through 2008. Results Approximately 70 years ago, clinicians from various disciplines relied on personal experience and clinical observations for outcome assessment of testosterone therapy in women. These early reports on testosterone use in women with sexual medical problems served as a foundation for the development of contemporary approaches and subsequent testosterone treatment regimens. Testosterone use was reported for sexual dysfunction, abnormal uterine bleeding, dysmenorrhea, menopausal symptoms, chronic mastitis and lactation, and benign and malignant tumors of the breast, uterus, and ovaries. Conclusions Health-care professionals engaged in the management of women’s health issues have observed the benefits of androgen therapy throughout much of the 20th century. Despite this clinical use of testosterone in women for more than seven decades, contemporary testosterone therapy in women is hotly debated, misunderstood, and often misrepresented in the medical community.

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“…Loeser reported that testosterone increased women's sexual libido [7]. This observation was further supported by studies reported by Greenblatt et al.…”

Section: Testosterone Therapy In Patients With Gynecological and Sexusupporting

confidence: 70%

Section: Androgen Therapy Of Sexual Dysfunctionmentioning

confidence: 99%

Testosterone Therapy in Women with Gynecological and Sexual Disorders: A Triumph of Clinical Endocrinology from 1938 to 2008

Traish

Feeley

Guay

2009

The Journal of Sexual Medicine

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“…The experimental observation that subdermal implants showed the most potent, lasting effects of any steroid formulation Parkes 1937,1938;Hamilton and Dorfman 1939) were quickly applied by clinical investigators (Vest and Howards 1939;Howards and Vest 1939;Foss 1939) and testosterone implants became an established form of androgen replacement therapy. Similar effects were observed for most biologically active steroids and their esters including androgens, estrogens and progestagens (Loeser 1940;Eidelsberg and Ornstein 1940;Emmens 1941;Forbes 1941;Biskind et al 1941;Dorfman and Hamilton 1941;Foss 1942) and very long acting depot formulations of desoxycorticosterone acetate (DOCA) lasting up to 1 year were developed for treatment of Addisons disease (Thorn and Firor 1940).…”

Section: Historymentioning

confidence: 73%

Testosterone

1990

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“…Shorr et al postulated that androgens not only act on the central nervous system but also at the peripheral genital level [7]. Shortly thereafter, Loeser reported that all women treated with testosterone experienced increased sexual drive, suggesting that androgens play a physiological role in enhancing libido and arousal in women [8]. These observations were further confirmed by several subsequent studies [6,9,10,11,12].…”

Section: A Historical Perspective On Androgen Therapy In Womenmentioning

confidence: 88%

Are the Endocrine Society's Clinical Practice Guidelines on Androgen Therapy in Women Misguided? A Commentary

Traish

Guay

Spark

et al. 2007

The Journal of Sexual Medicine

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The Endocrine Society Clinical Guidelines on Androgen Therapy in Women (henceforth referred to as the Guidelines) do not necessarily represent the opinion held by the many health-care professionals and clinicians who are specialized in the evaluation, diagnosis, and treatment of women's health in androgen insufficiency states. The recommendations provided in the published Guidelines are neither accurate nor complete. We disagree with the therapeutic nihilism promoted by these Guidelines. The members of the Guidelines Panel (henceforth referred to as the Panel), in their own disclaimer, stated that the Guidelines do not establish a standard of care. Based on data available in the contemporary literature, on the role of androgens in women's health, we provide in this commentary a point-by-point discussion of the arguments made by the Panel in arriving at their recommendations. It is our view that the Guidelines are not based on the preponderance of scientific evidence. Health-care professionals, physicians, and scientists often disagree when determining how best to address and manage new and emerging clinical issues. This is where we stand now as we endeavor to understand the role of androgens in a woman's health and welfare. Indeed, some basic facts are not in contention. All agree that dehydroepiandrosterone sulfate (DHEA-S) production from the adrenal gland begins during the preteen years, peaks in the mid 20s, then declines progressively over time. In contrast, ovarian androgen (i.e., testosterone) secretion commences at puberty, is sustained during a woman's peak reproductive years and declines as a woman ages, with a more rapid and steep decrease after surgical menopause. However, there are ample data to suggest that adrenal androgens play a role in the development of axillary and pubic hair, and that testosterone is critical for women's libido and sexual function. We take this opportunity to invite members of the Panel on Androgen Therapy in Women to discuss, clarify, comment, or rebut any of the points made in this Commentary. It is our goal to elevate this debate in order to provide women who are afflicted with androgen insufficiency and sexual disorders with the highest quality health care and to relieve their distress and suffering, as well as to improve their quality of life.

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Subcutaneous Implantation of Female and Male Hormone in Tablet Form in Women

Abstract: August 22 the uterus was curetted and the endometrium was MARCii

Cited by 42 publications

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Testosterone Therapy in Women with Gynecological and Sexual Disorders: A Triumph of Clinical Endocrinology from 1938 to 2008

Testosterone Therapy in Women with Gynecological and Sexual Disorders: A Triumph of Clinical Endocrinology from 1938 to 2008

Testosterone

Are the Endocrine Society's Clinical Practice Guidelines on Androgen Therapy in Women Misguided? A Commentary

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