Subcutaneous mycosis produced by Aureobasidium pullulans in a renal transplant recipient

Abstract

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Unusual Fungal Infections in Renal Transplant Recipients

“…Arranz Sánchez et al reported similar [18] skin lesions in a renal transplant recipient caused by A. pullulans which subsided within 2 months of ITR therapy with no relapse at one year of follow-up. However in our case the lesions recurred after 2 months despite the patient being on antifungal agents.…”

“…However in our case the lesions recurred after 2 months despite the patient being on antifungal agents. How long these lesions have to be treated has not been clearly defined [18, 19]. This case also highlights how crucial it is to optimize the TAC dose and monitor for nephrotoxicity when the patient is treated with antifungal drugs such as triazoles, owing to the drug interactions.…”

Disseminated fungal infection by Aureobasidium pullulans in a renal transplant recipient

“…Culture and microscopic examination remain the definitive methods to identify these fungi. Skin infections can be seen in immunocompetent hosts with soil‐contaminated wounds or with the introduction of foreign bodies into the skin, but it is now known to have been documented as causing cutaneous infection to invasive and potentially life‐threatening infections in humans . Among immunocompromised patients, organ transplant recipients may be at particularly higher risk.…”

“…Disseminated systemic infections by A. pullulans are very rare and occur in patients on broad‐spectrum antibiotics, invasive devices such as central venous catheters, and in immunocompromised patients . In an extensive search of the literature, we could find only three pediatric patients with A. pullulans fungemia .…”

“…In the literature, the association between A. pullulans spp. and human infectious diseases is described as being mainly associated to skin, soft tissue infections, fungemia (septicemia), systemic infections, and abscesses in different viscera …”