Subcutaneous Nodules and Infectious Complications in Renal Allograft Recipients

“…Localized extrapulmonary MAC infections are uncommon, but have been reported in the literature. Specifically, in renal transplant recipients, cases have described MAC infections involving the lymphatics, spleen, liver, bone marrow, joints, and skin as well as the renal allograft itself . However, reports of intestinal MAC infection in renal transplant recipients are rare (Table ) …”

Section: Discussionmentioning

confidence: 99%

A rare case of disseminated Mycobacterium avium complex with colitis in a renal transplant recipient

Ingilizova

Epstein

Lee

et al. 2018

Transplant Infectious Dis

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Mycobacterium avium complex (MAC) colitis is a rare complication of immunosuppression in solid organ transplant (SOT) recipients. Here, we describe a case of disseminated MAC infection with colitis following renal transplantation. Despite common pathways of immunosuppression, SOT recipients and human immunodeficiency virus (HIV)-infected patients differ in their typical presentations of MAC infection. Intestinal infections have been more commonly reported in HIV-infected patients than in SOT recipients. The explanation for this difference may be related to HIV's targeted effects on the CD4 + T-cell reservoir in gut-associated lymphoid tissue. K E Y W O R D S colitis, Mycobacterium avium complex, renal transplant

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“…Unlike Mycobacterium fortuitum complex, Mycobacterium marinum , Mycobacterium chelonae , and Mycobacterium ulcerans , MAC infections rarely involve the skin . From a large cohort of 774 KTRs, Caroti et al described only 2 lethal cases of disseminated MAC infections revealed by subcutaneous nodules. In our case, limb cutaneous lesions were consistent with this description.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium avium complex disseminated infection in a kidney transplant recipient

Fadlallah

Rammaert

Laurent

et al. 2016

Transplant Infectious Dis

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Mycobacterium avium-intracellulare complex (MAC) infections are well known in immunocompromised patients, notably in human immunodeficiency virus infection, but remain scarcely described in kidney transplantation. Moreover, cutaneous involvement in this infection is very unusual. We describe here a disseminated infection caused by MAC in a kidney transplant recipient revealed by cutaneous lesions. This case highlights the need for an exhaustive, iterative microbiologic workup in the context of an atypical disease presentation in a renal transplant patient, regardless of the degree of immunosuppression.

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Subcutaneous Nodules and Infectious Complications in Renal Allograft Recipients

Cited by 24 publications

References 9 publications

Severe dermatophytosis in solid organ transplant recipients: A French retrospective series and literature review

Severe dermatophytosis in solid organ transplant recipients: A French retrospective series and literature review

A rare case of disseminated Mycobacterium avium complex with colitis in a renal transplant recipient

Mycobacterium avium complex disseminated infection in a kidney transplant recipient

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