Subcutaneous Nodules with Pseudomas Septicaemia in an Immunocompetent Patient

Abstract

Pseudomonas septicaemia presenting with subcutaneous nodules, though rare, is well described in immuno-compromized populations. It is, however, very uncommon in immunocompetent patients. We describe a case of a 42-year-old woman who presented with community-acquired Pseudomonas aeruginosa septicaemia and subcutaneous nodules. No precipitating cause or immune dysfunction was found. She was successfully treated with appropriate antibiotics, respiratory and cardiovascular support in the Intensive Care Unit. The difficulty in eradicating the organism from the skin lesion and the need for investigating the immune function of septicaemia patients are discussed.

Late diagnosis of X-linked hyper-IgM syndrome presenting as community-acquired pseudomonas aeruginosa pneumonia-related septic shock

“…According to some cases 2,3 , community-acquired P. aeruginosa may cause severe aggressive infections in healthy children. 25% of fatal cases were found to carry novel pathogenic variants in PID genes by exome/genome sequencing in previously healthy children 4 . X-linked hyper-IgM syndrome (XHIGM; HIGM1; OMIM:308230) is one type of primary immunodeficiency disease(PIDs), resulting from defects in the CD40 ligand/CD40 signaling pathways leading to impairment of immunoglobulin isotype switching in B cells.…”