Subcutaneous phaeohyphomycosis caused by Pleurostomophora richardsiae in a renal transplant recipient

Tee, Louis Y.; Tan, Ban Hock; Tan, Ai-Ling; Busmanis, Inny; Oh, Choon Chiat

doi:10.1016/j.jdcr.2019.10.027

Cited by 7 publications

(2 citation statements)

References 7 publications

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“…As a result, we reviewed 228 published reports. We identified and included 149 reports on 201 cases of dematiaceous fungal infections in SOT recipients 21–169 . The majority (134/149; 90%) of included reports scored ≥ 2 of three possible points on our bias assessment (Table S4).…”

Section: Resultsmentioning

confidence: 99%

Dematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta‐analysis

Radcliffe

Azar

et al. 2022

Transplant Infectious Dis

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Background: Dematiaceous fungi cause a number of infectious syndromes referred to as phaeohyphomycosis among both immunocompetent and immunocompromised hosts. We performed a systematic review to characterize these infections in solid organ transplant recipients (SOTR). Methods:We searched PubMed database (last searched 1/6/2022) for Englishlanguage reports on dematiaceous fungal infections in SOTR. Included reports needed individualized demographic, treatment, and outcome data; pediatric reports were excluded. A universally applicable bias assessment was performed on reports. Models for infection type and outcome were created using the Bayesian paradigm. Results:We included 149 reports on 201 cases of dematiaceous fungal infections in SOTR. The mean age was 54 years, 72% were men, and kidney recipients accounted for 61% of cases. Skin and soft tissue infection (SSTI) was the most common infectious syndrome (73%). Death from infection occurred in 7% of cases (14/201), with disseminated (32%) cases having the highest mortality. Our model for infection type predicted the relative probability of central nervous system infection to be highest in liver recipients. Across all transplant types, higher relative probabilities of disseminated and pulmonary infections occur in the early post-transplant period, and the predicted probabilities for these infection types decreased after 100 months post-transplantation.Discussion: We identified SSTI as the most common dematiaceous fungal infections in SOTR. Disseminated infections carried the worst prognosis. The evidence in this review is limited by the heterogeneity of included cases. No funding source was used, and this review's protocol was not registered.

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Section: Resultsmentioning

confidence: 99%

Dematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta‐analysis

Radcliffe

Azar

et al. 2022

Transplant Infectious Dis

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“…Infection may result from close contact with Pleurostoma-contaminated plants or direct inoculation of contaminated materials into the body [7][8][9][10][11]. Very often Pleurostoma infections are localized and manifest as cutaneous or subcutaneous lesions and/or nodules [7][8][9][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], although infections of the bones/joints [9,20,22,[31][32][33][34][35], eyes [10,[35][36][37] and urinary tracts [38] are also observed. In more rare occasions especially in severely immunocompromised individuals, disseminated invasive infections affecting the bloodstreams, hearts and livers could also occur [35,39,40].…”

Section: Introductionmentioning

confidence: 99%

Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing

Tsang

Chan

et al. 2021

Emerging Microbes & Infections

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Pleurostoma species are wood-inhabiting fungi and emerging opportunistic pathogens causing phaeohyphomycosis. In this study, we isolated a dematiaceous fungus, HKU44 T , from the subhepatic abscess pus and drain fluids of a liver transplant recipient with post-transplant biliary and hepatico-jejunostomy bypass strictures. Histology of the abscess wall biopsy showed abundant fungal hyphae. The patient survived after a second liver transplant and antifungal therapy. On SDA, HKU44 T grew initially as white powdery colonies which turned beige upon maturation. Hyphae were septate and hyaline. Phialides were monophialidic and laterally located, generally closely associated to a cluster of conidia which were usually reniform. Phylogenetic analyses showed that HKU44 T is most closely related to, but distinct from, Pleurostoma ootheca and Pleurostoma repens . These suggested that HKU44 T is a novel Pleurostoma species, for which the name Pleurostoma hongkongense sp. nov. is proposed. Antifungal susceptibility testing showed that Pleurostoma species possessed high MICs/MECs for fluconazole, 5-flucytosine and the echinocandins; whereas they exhibited a high strain-to-strain variability to the susceptibilities to the other triazoles. As for amphotericin B, ∼65% of the Pleurostoma strains had low MICs (≤1 µg/mL). DNA sequencing should be performed to accurately identify fungi with Pleurostoma/Phialophora -like morphologies, so is antifungal susceptibility testing for patients with Pleurostoma infections.

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Azathioprine/everolimus/prednisolone

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Subcutaneous phaeohyphomycosis caused by Pleurostomophora richardsiae in a renal transplant recipient

Cited by 7 publications

References 7 publications

Dematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta‐analysis

Dematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta‐analysis

Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing

Azathioprine/everolimus/prednisolone

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