Subcutaneous phaeohyphomycosis of the face presenting as rhinoentomophthoramycosis

Mahajan, Vikram K.; Chauhan, Pushpinder S; Mehta, Karaninder S; Abhinav, C.; Sharma, Vikas; Thakur, Kamlesh

doi:10.1111/ijd.12166

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…Thus, improved formulations of SSKI that are more palatable, have simplified administration regimen, and have improved compliance are highly desirable. The observed improved efficacy of itraconazole in combination with SSKI versus either drug used alone in phaeohyphomycosis requires evaluation in the treatment of sporotrichosis as well [ 108 ]. The possible efficacy of topical eberconazole and topical formulations of amphotericin B in cutaneous sporotrichosis, as in case of cutaneous leishmaniasis, too needs assessment [ 107 , 109 , 110 ].…”

Section: Commentsmentioning

confidence: 99%

Sporotrichosis: An Overview and Therapeutic Options

Mahajan¹

2014

Dermatology Research and Practice

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195

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Sporotrichosis is a chronic granulomatous mycotic infection caused by Sporothrix schenckii, a common saprophyte of soil, decaying wood, hay, and sphagnum moss, that is endemic in tropical/subtropical areas. The recent phylogenetic studies have delineated the geographic distribution of multiple distinct Sporothrix species causing sporotrichosis. It characteristically involves the skin and subcutaneous tissue following traumatic inoculation of the pathogen. After a variable incubation period, progressively enlarging papulo-nodule at the inoculation site develops that may ulcerate (fixed cutaneous sporotrichosis) or multiple nodules appear proximally along lymphatics (lymphocutaneous sporotrichosis). Osteoarticular sporotrichosis or primary pulmonary sporotrichosis are rare and occur from direct inoculation or inhalation of conidia, respectively. Disseminated cutaneous sporotrichosis or involvement of multiple visceral organs, particularly the central nervous system, occurs most commonly in persons with immunosuppression. Saturated solution of potassium iodide remains a first line treatment choice for uncomplicated cutaneous sporotrichosis in resource poor countries but itraconazole is currently used/recommended for the treatment of all forms of sporotrichosis. Terbinafine has been observed to be effective in the treatment of cutaneous sporotrichosis. Amphotericin B is used initially for the treatment of severe, systemic disease, during pregnancy and in immunosuppressed patients until recovery, then followed by itraconazole for the rest of the therapy.

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Section: Commentsmentioning

confidence: 99%

Sporotrichosis: An Overview and Therapeutic Options

Mahajan¹

2014

Dermatology Research and Practice

Self Cite

195

194

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“…4 Patients present with features of recurrent sinusitis (fever, nasal obstruction, pain, mucosal hypertrophy of the sinuses, mid-face swelling or nasal mass). 5 The first report of human infection by entomophthoramycosis was in 1965. Wide ecological distribution and rapid growth may be responsible for the development of human disease.…”

Section: Discussionmentioning

confidence: 99%

Rhinoentomophthoramycosis: Madras ENT Research Foundation experience

Natarajan¹,

Gajapathy²,

Swathi³

et al. 2019

Int J Otorhinolaryngol Head Neck Surg

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<p>Rhinoentomophthoramycosis is a rare tropical fungal infection affecting the nasal cavities and the subcutaneous tissues. The most common causative organism is Conidiobolus coronatus followed by Basidiobolus. In our institution, two patients with Rhinoentomophthoramycosis were seen over a ten year period and were treated successfully with anti- fungal therapy. Rhinoentomophthoramycosis has to be considered in the differential diagnosis of a nasal granuloma or subcutaneous swellings in the face or neck.</p><p> </p>

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“…Gene sequencing of the internal transcribed spacer region is the most widely accepted molecular method becauseit can discriminate between inter and intraspecies variations. [8]…”

Section: Discussionmentioning

confidence: 99%

“…[9] While oral itraconazole is considered the empiric drug, voriconazole andposaconazole also show consistent in vitro activity against this group of fungi. [8]…”

Section: Discussionmentioning

confidence: 99%

Phaeohyphomycosis of the face masquerading as basal cell carcinoma in an immunocompetent patient

Sharma

Singh

Ramesh

et al. 2017

Indian Dermatol Online J

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Pheohyphomycosis is a rare heterogeneous group of mycotic infections caused by dermatiaceous (phaeoid) fungi affecting the skin, subcutaneous tissue, and the central nervous system.Involvement of the face is extremely rare, and very few cases have been reported in India so far. We reporta case of phaeohyphomycosisin a 45-year-old female with 1-year history of a well- defined hypertrophic plaque over the right cheek advancing towards the forehead. The lesion was ulcerated with rolled-up margins; a provisional clinical diagnosis of basal cell carcinoma was given. Histopathology of the skin biopsy revealed numerous multinucleated giant cells and fungal hyphae with in and in between the giant cells. Various histochemical stains were used toconfirm the presence of fungal hyphae. Melanin pigment in the fungus was demonstrated with Masson's Fontana stain. Based on the histopathological and histochemical findings, a diagnosis of phaeohyphomycosis was given and it was concluded that the disease was more of a histopathological than clinical diagnosis. This case is being reported due to its unusual presentation and it also highlights the importance of histopathology in the diagnosis of this rare disease.

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Subcutaneous phaeohyphomycosis of the face presenting as rhinoentomophthoramycosis

Abstract: Combination therapy with itraconazole and saturated solution of potassium iodide (SSKI) was more effective than itraconazole used alone.

Cited by 5 publications

References 15 publications

Sporotrichosis: An Overview and Therapeutic Options

Sporotrichosis: An Overview and Therapeutic Options

Rhinoentomophthoramycosis: Madras ENT Research Foundation experience

Phaeohyphomycosis of the face masquerading as basal cell carcinoma in an immunocompetent patient

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