Subcutaneous Zygomycosis

Ellis, David

doi:10.1002/9780470688618.taw0144

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2021

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“…Thhe disease is mainly reported from tropical and subtropical regions. Basidiobolus (Order: Entomophthorales) is a zygomycete filamentous fungus isolated from plant debris, soil, amphibians, reptiles, and insectivorous bats, and lice (1,2). One of the severe forms of basidiobolomycosis is human gastrointestinal basidiobolomycosis (GIB).…”

Section: Introductionmentioning

confidence: 99%

Antifungal activities of artesunate, chloramphenicol, and cotrimoxazole againstBasidiobolusspecies, the causal agents of gastrointestinal basidiobolomycosis

Al‐Qahtani¹,

Joseph

Al‐Hakami

et al. 2021

Preprint

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Basidiobolus species (n =13) isolated from human gastrointestinal basidiobolomycosis and lizards were tested against artesunate, chloramphenicol, and cotrimoxazole. The three agents exhibited inhibitory actions against Basidiobolus species comparable to the known antifungals. The combined effects of artesunate + voriconazole and cotrimoxazole + voriconazole have significant synergic effects, p = 0.003 and p = 0.021, respectively. These are promising results that enhance accelerated combined treatment of GIB in humans particularly the combination of artesunate and voriconazole.

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Section: Introductionmentioning

confidence: 99%