Subdiffusive Motion of STIM1 at ER Membrane and ER-Plasma Membrane Junction

Abstract

Recently, we demonstrated the use of 31 P CODEX (Centerband-Only Detection of Exchange) NMR to measure lateral diffusion of phospholipids.Here we demonstrate the multiplexing capabilities of CODEX, i.e. simultaneous measurement of multiple phospholipid lateral diffusion coefficients, and compare the effects of polylysine and a model anti-microbial peptide, KL-14 (KKLLK KAKKL LKKL), on lateral diffusion of various anionic phospholipids.