Subdiuretic dose of furosemide enhances albuterol effects in asthmatic mice rather than bumetanide

Murad, Hussam; Ghabrah, Tawfik M.; Rafeeq, Misbahuddin M; Ali, Soad Shaker

doi:10.1016/j.aller.2018.05.001

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Inhaled furosemide has been demonstrated to decrease inflammatory cytokines and airway hyper-reactivity in asthmatic subjects [ 63 ], but its influence on allergic asthmatic reactions in mice is ambiguous. Depending on the experimental settings, furosemide has been shown to either increase the infiltration of T lymphocytes [ 64 ], or to reduce the infiltration of pulmonary inflammatory cells [ 65 ]. Furosemide and spironolactone reduce the migration of leukocytes through endothelial cell monolayers [ 66 ].…”

Section: Resultsmentioning

confidence: 99%

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Immunomodulatory Potential of Diuretics

Bryniarski

Nazimek

Marcinkiewicz

2021

Biology

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In this review, diuretics and their immunomodulatory functions are described. The effects on the immune response of this group of drugs are reported in patients suffering from hypertension and under experimental conditions involving animal models and cell line studies. The pathogenesis of hypertension is strongly connected to chronic inflammation. The vast majority of diuretics modulate the immune response, changing it in favor of the anti-inflammatory response, but depending on the drug, these effects may differ. This topic is significantly important in medical practice regarding the treatment of patients who have coexisting diseases with chronic inflammatory pathogenesis, including hypertension or chronic heart failure. In patients with metabolic syndrome, allergies, or autoimmune disorders, the anti-inflammatory effect is favorable, because of the overstimulation of their immune system. Otherwise, in the geriatric population, it is important to find the proper anti- and pro-inflammatory balance to avoid an enhancement of immune response suppression, which can result in reducing the risk of serious infections that can occur due to the age-diminished function of the immune system. This article is intended to facilitate the selection of an antihypertensive drug that depends on the patient’s immune situation.

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Section: Resultsmentioning

confidence: 99%

“…Allergic asthmatic reactions in mice (ambiguous: depending on the experimental settings, it has been shown to either increase the infiltration of T lymphocytes [ 64 ], or to reduce the infiltration of pulmonary inflammatory cells [ 65 ]);…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Potential of Diuretics

Bryniarski

Nazimek

Marcinkiewicz

2021

Biology

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“…Furosemide is commonly administered as a diuretic either orally or intravenously, but it has a long history of administration by inhalation as a bronchodilator or for dyspnea (17)(18)(19). Multiple clinical investigations have reported reduction in lung IL-6, IL-8, and TNF levels upon administering inhaled furosemide to patients with respiratory conditions (20,21). Dosing of inhaled furosemide is variable across studies, ranging from 20 to 120 mg per dose across studies with 40 mg of furosemide being the most commonly used dose (18,22).…”

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confidence: 99%

Nebulized Furosemide for Pulmonary Inflammation in Intubated Patients With COVID-19: A Phase 2 Randomized Controlled Double-Blind Study

Muscedere,

Maslove,

Barden

et al. 2024

Critical Care Explorations

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OBJECTIVES: Respiratory failure secondary to COVID-19 is associated with morbidity and mortality. Current anti-inflammatory therapies are effective but are given systemically and have significant side effects. Furosemide has anti-inflammatory properties, can be administered by inhalation, and is inexpensive. We investigated the efficacy of nebulized furosemide as an adjunctive therapy for COVID-19 respiratory failure. DESIGN: A double-blind, randomized, placebo-controlled trial. SETTING: Multicenter ICU study. PATIENTS: Adults requiring invasive mechanical ventilation secondary to COVID-19. INTERVENTION: Patients were randomized within 48 hours of intubation to receive inhaled furosemide or placebo until day 28, death, or liberation from mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: The study was stopped early due to waning incidence of COVID-19; 39 patients were available for analysis with mean ± sd age of 70.5 (10.8) years, Acute Physiology and Chronic Health Evaluation II 26.1 (7.8) and Fio 2 60.0% (21.9). Baseline characteristics were similar between the groups. For the primary outcome of change in Pao 2/Fio 2 ratio between day 1 and day 6, it was +31.4 (83.5) in the furosemide arm versus +20.1 (92.8) in the control (p = 0.58). For secondary outcomes, furosemide versus control: 60-day mortality was 48% versus 71% (p = 0.20), hospital stay was 25.6 (21.9) versus 27.4 (25.0) days, p = 0.94 and VFD was 6.0 (9.1) versus 3.1 (7.1), p value of equals to 0.28. A post hoc analysis of the hierarchical composite outcome, alive and ventilator-free favored furosemide. There were no adverse events. CONCLUSIONS: In this trial of inhaled furosemide for COVID-19 respiratory failure, differences in Pao 2/Fio 2 ratio to day 6 and other clinical outcomes were not significantly different, although the trial was underpowered due to early termination. Given the favorable profile of inhaled furosemide, further study is warranted in disease states where acute pulmonary inflammation contributes to the underlying pathophysiology.

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Effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery: A randomized controlled trial

Wang

Chen

et al. 2023

Advances in Oral and Maxillofacial Surgery

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Subdiuretic dose of furosemide enhances albuterol effects in asthmatic mice rather than bumetanide

Abstract: Inhaled subdiuretic dose of furosemide enhanced effects of albuterol more in ovalbumin-asthmatic mice rather than bumetanide, while oral diuretic doses of both drugs failed to improve asthma, indicating that this enhancing effect is not diuretic-related.

Cited by 3 publications

References 33 publications

Immunomodulatory Potential of Diuretics

Immunomodulatory Potential of Diuretics

Nebulized Furosemide for Pulmonary Inflammation in Intubated Patients With COVID-19: A Phase 2 Randomized Controlled Double-Blind Study

Effects of postoperative nebulized furosemide and budesonide on postoperative sore throat in patients undergoing maxillofacial surgery: A randomized controlled trial

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