Subdural compartment in pig: A morphologic study with blood and horseradish peroxidase infused subdurally

Orlin, Jan Roar; Osen, Kirsten K.; Hovig, Torstein

doi:10.1002/ar.1092300104

Cited by 93 publications

(81 citation statements)

References 39 publications

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“…is formed within the split dural border cell layer." The exprimental data of Orlin et al (1991) also support this fundamental concept. The available evidence from studies on normal animal and human meninges, from investigations on pathological specimens, and from animal experiments, supports the view that the so-called "subdural" hematoma is not subdural in its location but is mainly formed by a splitting open of the DBC layer.…”

Section: A Potential Space?supporting

confidence: 65%

“…CAPSULE OF THE "SUBDURAL HEMATOMA' If, as has been suggested (Waggener and Beggs, 1967;Nabeshima et al, 1975;Rascol and Izard, 1976;Friede and Schachenmayr, 1978;Friede, 1978, 1979;Yamashima and Friede, 1984;Orlin et al, 1991), the formation of a so-called subdural hematoma is the result of a shearing open of the DBC layer (Figs. 8C, 9A); evidence of the cell type characteristic of this layer should be seen in the capsule surrounding this lesion in human material.…”

Section: A Potential Space?mentioning

confidence: 88%

“…1). Orlin et al (1991) offer a n alternative interpretation by suggesting that this layer of flattened cells, the DBC layer of the present review, forms a separate meningeal layer designated by them as the "subdural compartment." Collagen, elastic fibrils, and some microfibrils, while present at this junction ( Fig.…”

Section: Dural Border Cell Layermentioning

confidence: 91%

“…3, 4; see also Fig. 9), a prominent Golgi apparatus, granular endoplasmic reticulum, free ribosomes, microtubules, filaments/tonofilaments (many in association with desmosomes), and, infrequently, lipid droplets, lyosomes, and some small vesicles (Andres, 1967;Klika, 1967;Waggener and Beggs, 1967;Akashi, 1972;Rascol and Izard, 1976;Schachenmayr and Friede, 1978;McLone, 1980;Oda and Nakanishi, 1984;Yamashima and Friede, 1984;Alcolado et al, 1988;Orlin et al, 1991). The nuclei of these cells (Fig.…”

Section: Arachoid Barrier Cell Layer and The Arachnoid Trabeculaementioning

confidence: 94%

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On the question of a subdural space

1991

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The structure of the meninges, with particular attention to the architecture of the inner portions of the dura mater and the arachnoid mater, has been reviewed in reference to the probable existence of a "subdural" space. The dura is composed of fibroblasts and large amounts of extracellular collagen. The innermost part of the dura is formed by the dural border cell layer. This layer is characterized by flattened cells with sinuous processes, extracellular spaces containing an amorphous material, and the presence of junctions between its cells. The dural border cell layer is continuous with the inner (meningeal) portions of the dura and may be attached to the underlying arachnoid by an occasional cell junction. The arachnoid consists of an outer part, the arachnoid barrier cell layer, and an inner portion, the arachnoid trabeculae which bridge the subarachnoid space. Arachnoid barrier cells are electron-lucent, closely apposed to each other, and joined by many cell junctions; in this layer there is little extracellular space and essentially no intercellular material. Arachnoid trabecular cells cross the subarachnoid space in a random manner, have extracellular collagen associated with their flattened processes, and form structures of variable shapes and sizes. There is no evidence of an intervening space between the arachnoid barrier cell layer and the dural border cell layer that would correlate with what has been called the subdural space. When a tissue space is created in this general area of the meninges it is the result of tissue damage and represents, in most instances, a cleaving open of the dural border cell layer. In this situation, extracellular spaces in the dural border cell layer are enlarged, cell junctions are separated, and it is probable that cell membranes are damaged. A survey of reports describing the morphology of the inner and outer capsule of so-called subdural hematomas in humans reveals that dural border cells are found in both parts of the capsule. Also, experimental infusion of blood into this portion of the meninges in animals frequently dissects open the dural border cell layer. These data support the view that what has been called a subdural hematoma is most frequently a lesion found within the layer formed by dural border cells. It is suggested that the so-called subdural space is not a "potential" space since the creation of a cleft in this area of the meninges is the result of tissue damage. In this respect it shares no similarities with legitimate potential spaces (i.e., serous cavities) found at other locations in the body.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: A Potential Space?supporting

confidence: 65%

Section: A Potential Space?mentioning

confidence: 88%

Section: Dural Border Cell Layermentioning

confidence: 91%

Section: Arachoid Barrier Cell Layer and The Arachnoid Trabeculaementioning

confidence: 94%

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On the question of a subdural space

1991

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“…11) Moreover, experiments showed that under normal conditions there is no evidence of the so-called`subdural space.' 9) When animals are subjected to subdural infusion of blood or bleeding takes place into the dural border cell layer, it splits without any particular predestined cleavage plane, although most often the cleavage passes close to the fibrous matter of the dura. The bleeding extends throughout the cerebral and spinal parts of the dural border cell layer and along the spinal nerve roots.…”

Section: Discussionmentioning

confidence: 99%

Spinal Subdural Hematoma Following Intracranial Aneurysm Surgery-Four Case Reports-

Kim

Lee

et al. 2007

Neurol. Med. Chir.(Tokyo)

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Four patients presented with rare spinal subdural hematoma (SDH) occurring after intracranial aneurysm surgery and manifesting as postoperative back pain. Magnetic resonance imaging performed from 4 to 11 days after the operation showed acute or subacute thoracolumbar SDH. No patient had risk factors for bleeding at this site (e.g., lumbar puncture, coagulation abnormality). Overdrainage of the cerebrospinal fluid (CSF) was performed for brain retraction during the operation in all four cases. Computed tomography performed during the postoperative period showed a suspicious tentorial subdural hemorrhage in Case 1 and an interhemispheric subdural hemorrhage in Case 3. All four patients received conservative management and their lumbago improved. We hypothesize that CSF hypotension due to overdrainage of CSF and downward migration of intracranial SDH under the influence of gravity were involved in the formation of spinal SDH.

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Anatomical correlates for the newly discovered meningeal layer in the existing literature: A systematic review

Kumar,

Narayan

et al. 2024

The Anatomical Record

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The existence of a previously unrecognized subarachnoid lymphatic‐like membrane (SLYM) was reported in a recent study. SLYM is described as an intermediate leptomeningeal layer between the arachnoid and pia mater in mouse and human brains, which divides the subarachnoid space (SAS) into two functional compartments. Being a macroscopic structure, having missed detection in previous studies is surprising. We systematically reviewed the published reports in animals and humans to explore whether prior descriptions of this meningeal layer were reported in some way. A comprehensive search was conducted in PubMed/Medline, EMBASE, Google Scholar, Science Direct, and Web of Science databases using combinations of MeSH terms and keywords with Boolean operators from inception until 31 December 2023. We found at least eight studies that provided structural evidence of an intermediate leptomeningeal layer in the brain or spinal cord. However, unequivocal descriptions for this layer all along the central nervous system were scarce. Obscure names like the epipial, intermediate meningeal, outer pial layers, or intermediate lamella were used to describe it. Its microscopic/ultrastructural details closely resemble the recently reported SLYM. We further examined the counterarguments in current literature that are skeptical of the existence of this layer. The potential physiological and clinical implications of this new meningeal layer are significant, underscoring the urgent need for further exploration of its structural and functional details.

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Subdural compartment in pig: A morphologic study with blood and horseradish peroxidase infused subdurally

Cited by 93 publications

References 39 publications

On the question of a subdural space

On the question of a subdural space

Spinal Subdural Hematoma Following Intracranial Aneurysm Surgery-Four Case Reports-

Anatomical correlates for the newly discovered meningeal layer in the existing literature: A systematic review

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