Subendocardial infarction and thrombocytopenia

Fireman, Zvi; Yust, Israel; Zahavi, J.; Kahn, Y.; Abramov, Leon A.

doi:10.1136/pgmj.55.639.36

Cited by 11 publications

(3 citation statements)

References 7 publications

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“…At least 20 patients (1 from personal files and 19 from the literature) with ITP were found to have had arterial thrombosis (15 MI, 2 unstable angina, 2 ischemic stroke, and 1 peripheral arteries thrombosis). 4,6,8,11 –27 Another patient, from personal files, had to be excluded because at time of thrombosis (MI), the platelet level was 100 × 10 3 /μL. 28 Age varied between 37 and 80.…”

Section: Resultsmentioning

confidence: 99%

“…However, both congenital and acquired forms of thrombocytopenia have been occasionally associated with arterial and/or venous thrombosis. [4][5][6][7][8][9][10] The purpose of the present study was to analyze critically all reported cases of thrombosis in patients with idiopathic or immunological thrombocytopenic purpura (ITP) in an attempt to clarify the role played in these patients by different potential prothrombotic mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…However, both congenital and acquired forms of thrombocytopenia have been occasionally associated with arterial and/or venous thrombosis. 4 –10…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Arterial and Venous Thromboses in Patients With Idiopathic (Immunological) Thrombocytopenia

Girolami

Marinis

Bonamigo

et al. 2012

Clin Appl Thromb Hemost

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Immunological thrombocytopenias, as other forms of thrombocytopenia, are associated with bleeding. Occasionally, these patients manifest thrombotic events. A total of at least 29 patients were reported to have had either arterial (20 cases) or venous (9 cases) thrombosis while platelet count was less than 50 × 10(3)/μL. The most frequent clinical manifestation was a myocardial infarction. Thrombosis occurred in the large majority of patients during prednisone therapy. Patients receiving cortisone or patients with Cushing syndrome show a hypercoagulable state characterized by elevated factor VIII levels, decreased fibrinolysis, and abnormal von Willebrand factor multimers composition. The same is probably true for prednisone-treated patients with thrombocytopenia. However, the 2 conditions are not identical since prednisone is a mainly glycoactive compound, whereas cortisol produced in excess in Cushing syndrome is mainly mineraloactive. The presence of large, young, hyperactive platelets may also play a role. Prednisone-treated patients with thrombocytopenia have to be considered as potentially thrombophilic.

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