Subendocardial versus transmural ischaemia in myocardial perfusion SPECT – a Monte Carlo study

Bartosik, Jolanta; Ali, Henrik H. El; Nilsson, Ulf; Dahlström, Jan Anders; Edenbrandt, Lars; Ljungberg, Michael

doi:10.1111/j.1475-097x.2006.00705.x

Cited by 4 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the magnitude of the improvement is in concordance with the global changes, we suppose that the majority of the benefit of the cardiac stem cell therapy is related to the intramyocardial delivery; although the additional effect of the intracor-onary stem cell delivery should also be taken into account. The myocardial perfusion imaging with SPECT is the only useful tool for the evaluation of the lesion volume (extent) and reduction in the blood perfusion (severity) of a mal-perfused myocardial area (26,27). Analysis of these two parameters allows to separate the transmural and subendocardial lesions with the same extent, as the severity of the perfusion defect differs.…”

Section: Hot Topics In Cardiovascular Cell and Pharmacotherapymentioning

confidence: 99%

Effect of intramyocardial delivery of autologous bone marrow mononuclear stem cells on the regional myocardial perfusion

Charwat

Lang²,

Dettke³

et al. 2010

Thromb Haemost

View full text Add to dashboard Cite

SummaryThe aim of the sub-study of the MYSTAR randomised trial was to analyse the changes in myocardial perfusion in NOGA-defined regions of interest (ROI) with intramyocardial injections of autologous bone marrow mononuclear cells (BM-MNC) using an elaborated transformation algorithm. Patients with recent first acute myocardial infarction (AMI) and left ventricular (LV) ejection fraction (EF) between 30-45% received BM-MNC by intramyocardial followed by intracoronary injection 68 ± 34 days post-AMI (pooled data of MYSTAR). NOGA-guided endocardial mapping and 99m -Sestamibi-SPECT (single photon emission computer tomography) were performed at baseline and at three months follow-up (FUP). ROI was delineated as a best polygon by connecting of injection points of NOGA polar maps. ROIs were projected onto baseline and FUP polar maps of SPECT calculating the perfusion severity of ROI. Infarct size was decreased (from 27.2 ± 10.7% to 24.1 ± 11.5%, p<0.001), and global EF increased (from 38 ± 6.1% to 41.5 ± 8.4%, p<0.001) three months after BM-MNC delivery. Analysis of ROI resulted in a significant increase in unipolar voltage (index of myocardial viability) (from 7.9 ± 3.0 mV to 9.9 ± 2.7 mV at FUP, p<0.001) and local linear shortening (index of local wall motion disturbances) (from 11.0 ± 3.9% to 12.7 ± 3.4%, p=0.01). NOGA-guided analysis of the intramyocardially treated area revealed a significantly increased tracer uptake both at rest (from 56.7 ± 16.1% to 62.9 ± 14.2%, p=0.003) and at stress (from 59.3 ± 14.2% to 62.3 ± 14.9%, p=0.01). Patients exhibiting ≥5% improvement in perfusion defect severity received a significantly higher number of intramyocardial BM-MNC. In conclusion, combined cardiac BM-MNC delivery induces significant improvement in myocardial viability and perfusion in the intramyocardially injected area.

show abstract

Section: Hot Topics In Cardiovascular Cell and Pharmacotherapymentioning

confidence: 99%

Effect of intramyocardial delivery of autologous bone marrow mononuclear stem cells on the regional myocardial perfusion

Charwat

Lang²,

Dettke³

et al. 2010

Thromb Haemost

View full text Add to dashboard Cite

show abstract

“…SPECT was extensively used for this purpose, however the modality may not recognize small perfusion defect in subendocardial infarcts (103). Gadolinium DE-CMR is the current clinical standard for (104).…”

Section: A B and The Assessment Of MI Ischemia And Viability (88)mentioning

confidence: 99%

Infarct characterization using CT

Grutta

Toia

Maffei

et al. 2017

Cardiovasc. Diagn. Ther.

View full text Add to dashboard Cite

Myocardial infarction (MI) is a major cause of death and disability worldwide. The incidence is not expected to diminish, despite better prevention, diagnosis and treatment, because of the ageing population in industrialized countries and unhealthy lifestyles in developing countries. Nowadays it is highly requested an imaging tool able to evaluate MI and viability. Technology improvements determined an expansion of clinical indications from coronary plaque evaluation to functional applications (perfusion, ischemia and viability after MI) integrating additional phases and information in the mainstream examination.Cardiac computed tomography (CCT) and cardiac MR (CMR) employ different contrast media, but may characterize MI with overlapping imaging findings due to the similar kinetics and tissue distribution of gadolinium and iodinated contrast media. CCT may detect first-pass perfusion defects, dynamic perfusion after pharmacological stress, and delayed enhancement (DE) of non-viable territories.

show abstract

Diagnostic accuracy of subendocardial vs. transmural myocardial perfusion defect for the detection of in-stent restenosis or progression of coronary artery disease after percutaneous coronary intervention

Mushtaq

Conte

Trabattoni

et al. 2023

Journal of Cardiovascular Computed Tomography

View full text Add to dashboard Cite

Subendocardial versus transmural ischaemia in myocardial perfusion SPECT – a Monte Carlo study

Cited by 4 publications

References 22 publications

Effect of intramyocardial delivery of autologous bone marrow mononuclear stem cells on the regional myocardial perfusion

Effect of intramyocardial delivery of autologous bone marrow mononuclear stem cells on the regional myocardial perfusion

Infarct characterization using CT

Diagnostic accuracy of subendocardial vs. transmural myocardial perfusion defect for the detection of in-stent restenosis or progression of coronary artery disease after percutaneous coronary intervention

Contact Info

Product

Resources

About