Subependymomas – Characteristics of a “Leave me Alone” Lesion

Kammerer, Sarah; Mueller-Eschner, Monika; Lauer, Arne; Luger, Anna‐Luisa; Quick-Weller, Johanna; Franz, Kea; Harter, Patrick N.; Berkefeld, Joachim; Wagner, Marlies

doi:10.1055/a-0576-1028

Cited by 8 publications

(11 citation statements)

References 20 publications

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“…Though the majority of cases in our study demonstrated enhancement, it is worth noting that most of these tumors exhibited relatively mild to moderate enhancement. This is generally consistent with what has been previously described in multiple retrospective case series with regards to intracranial subependymoma [ 8 , 10 – 12 , 16 – 18 , 21 , 22 ]. It is worth noting that none of our lesions demonstrated complete enhancement, and only one demonstrated avid enhancement.…”

Section: Discussionsupporting

confidence: 92%

“…The most common symptoms noted in our study included headache and dizziness, which are consistent with the literature [10,14,22,29]. Obstructive hydrocephalus was also observed in three of our patients before surgery, which was noted in the literature to be a particular sequelae of fourth ventricle subependymoma [10,17,18]. None of the cases in our study experienced tumor recurrence, consistent with the literature regarding the clinical management and cellular growth of intracranial subependymoma [8,9,[12][13][14][15]30].…”

Section: Discussionsupporting

confidence: 90%

“…C Axial T2 image of a typical mildly T2 hyperintense subependymoma at midline extending toward the foramen of Magendie. D Axial T2 image of a more T2 hyperintense subependymoma extending through the foramen of Luschka bilaterally and diagnosis [18]. However, we observed that the larger tumors in our study appeared to have a greater incidence of extension outside of the fourth ventricle.…”

Section: Discussioncontrasting

confidence: 51%

“…As noted in the literature, intracranial subependymomas are most commonly found in the fourth and lateral ventricles [ 10 , 16 – 18 ]. Within the fourth ventricle, we observed all of the subependymomas in our study to be centered below the body of the fourth ventricle and terminating at the level of the obex.…”

Section: Discussionmentioning

confidence: 99%

“…Nearly half of the cases in our study demonstrated tumor extension outside of the fourth ventricle, either into foramen of Magendie or Luschka. Though sparingly noted in the literature, no studies have drawn any correlation between subependymoma extension outside of the fourth ventricle and diagnosis [ 18 ]. However, we observed that the larger tumors in our study appeared to have a greater incidence of extension outside of the fourth ventricle.…”

Section: Discussionmentioning

confidence: 99%

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Imaging characteristics of 4th ventricle subependymoma

et al. 2022

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Purpose Subependymomas located within the 4th ventricle are rare, and the literature describing imaging characteristics is sparse. Here, we describe the clinical and radiological characteristics of 29 patients with 4th ventricle subependymoma. Methods This is a retrospective multi-center study performed after Institutional Review Board (IRB) approval. Patients diagnosed with suspected 4th ventricle subependymoma were identified. A review of clinical, radiology, and pathology reports along with magnetic resonance imaging (MRI) images was performed. Results Twenty-nine patients, including 6 females, were identified. Eighteen patients underwent surgery with histopathological confirmation of subependymoma. The median age at diagnosis was 52 years. Median tumor volume for the operative cohort was 9.87 cm3, while for the non-operative cohort, it was 0.96 cm3. Thirteen patients in the operative group exhibited symptoms at diagnosis. For the total cohort, the majority of subependymomas (n = 22) were isointense on T1, hyperintense (n = 22) on T2, and enhanced (n = 24). All tumors were located just below the body of the 4th ventricle, terminating near the level of the obex. Fourteen cases demonstrated extension of tumor into foramen of Magendie or Luschka. Conclusion To the best of our knowledge, this is the largest collection of 4th ventricular subependymomas with imaging findings reported to date. All patients in this cohort had tumors originating between the bottom of the body of the 4th ventricle and the obex. This uniform and specific site of origin aids with imaging diagnosis and may infer possible theories of origin.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Imaging characteristics of 4th ventricle subependymoma

et al. 2022

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Surgical management of subependymoma in a cat

Sakamoto

Chambers

Fujimoto³

et al. 2022

Vet Record Case Reports

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A 10‐year‐old, domestic shorthair cat was presented with a 7‐month history of anorexia and 2‐month history of severe obtundation. Neurological examination revealed proprioceptive ataxia and decreased postural reactions in the four limbs. On magnetic resonance imaging, a contrast‐enhanced mass lesion dorsal to the obex region was found, causing cerebellar and brainstem compression. The mass was aspirated by an ultrasonic aspirator and complete removal was achieved. After surgery, the mental status and appetite of the cat was markedly improved. On histopathological examination, the mass was diagnosed as subependymoma. The cat was neurologically normal, and no recurrence was observed on magnetic resonance imaging 3 months postoperatively. There was no evidence of clinical recurrence at 8 month postoperative follow‐up by telephone interview. This is the first description of surgical management of subependymoma in a cat. Subependymoma is a benign tumour in cats, and the prognosis is expected to be good after surgical management as reported in humans.

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