Subepidermal Calcified Nodule in the Periocular Region: A Report of 6 Cases

Shields, Carol L.; Marous, Molly R.; Casey, Mairghread G.; Douglass, Alexzandra M.; Khoo, Chloe T.L.; Bilyk, Jurij R.; Shields, Jerry A.; Eagle, Ralph C.

doi:10.1016/j.ophtha.2015.10.015

Cited by 10 publications

(10 citation statements)

References 4 publications

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“…In a previous study, Evans et al identified 21 cases of SCN age varied between 1-17 years old (mean 8.4 years old) with male dominance (14M/7F), 14 of which occurred in the head and neck region [ 4 ]. Shields et al reported a mean age of 12 years in six cases of periocular SCN [ 14 ]. Khine et al demonstrated the male predominance (67% male vs 33% female) and most of the patients (89%) were younger than 21 years of age [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…It can also present as a skin-colored or erythematous nodule [ 15 ]. When it presents as a single nodule, it can clinically mimic epidermal inclusion cyst, calcifying pilomatrixoma, hemangioma, or seborrheic keratosis [ 8 , 9 , 14 ]. When it presents as multiple nodules, the differential diagnosis includes verrucous papilloma, xanthomas, molluscum contagiosum, and milia.…”

Section: Discussionmentioning

confidence: 99%

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Subepidermal Calcified Nodule in a Child With Neurofibromatosis Type 1

Bagci¹,

Karakaş²,

Gökden³

2022

Cureus

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Calcinosis cutis (CC) is characterized by calcium deposition in the subcutaneous tissues. Subepidermal calcified nodule (SCN) is a variant of idiopathic calcinosis most commonly seen in the head and neck region of children and adolescents as a single, small, painless, yellow-white papule. A 13-year-old boy with a medical history of neurofibromatosis type 1 (NF1) presented with a firm 0.3 cm white papule in the lower eyelid. He also had neurofibromas of the left forearm and spinal cord, and a malignant peripheral nerve sheath tumor of the right forearm. The eyelid lesion showed hyperkeratotic epidermis, papillomatosis, and elongated rete ridges, with a radial arrangement at the periphery of the well-circumscribed lesion comprising many dystrophic calcifications, histiocytes, and foreign body giant cell reactions. To our knowledge, this is the first case of SCN reported in the context of NF1 or any other systemic disease in the English literature. Although a coincidence is likely, rare observations of the parathyroid gland and calcium metabolism disorders in association with NF1 may provide an explanation that requires further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Subepidermal Calcified Nodule in a Child With Neurofibromatosis Type 1

Bagci¹,

Karakaş²,

Gökden³

2022

Cureus

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“…Types of calcinosis cutis include metastatic calcinosis, dystrophic calcinosis, iatrogenic calcinosis, idiopathic calcinosis, and subepidermal calcified nodule . Although some types of calcinosis cutis, such as metastatic calcinosis and dystrophic calcinosis, are associated with metabolic or rheumatologic conditions, such as dermatomyositis and scleroderma, subepidermal calcified nodules are benign and idiopathic lesions that are not typically associated with an underlying disorder …”

Section: Discussionmentioning

confidence: 99%

“…SCN is a histopathologic diagnosis. Histopathology demonstrates characteristic deposits of calcium consisting of homogenous basophilic globules and granules of various sizes in the upper dermis . The treatment of choice for SCN is surgical excision …”

Section: Discussionmentioning

confidence: 99%

A facial cutaneous horn

Ashchyan

Treat

Rubin

2018

Pediatric Dermatology

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A 6-year-old African-American girl with a history of biliary atresia after choledochoduodenostomy, hypothyroidism, and vitamin D deficiency presented to our clinic with a solitary cutaneous horn on the left ear.The lesion was asymptomatic. She had first noticed the lesion approximately 1 year before presentation and noticed slow growth since then. Her current medications included levothyroxine 44 lg/d and cholecalciferol 400 IU/d. Physical examination revealed a hard, exophytic horn measuring 1.6 by 0.4 by 0.4 cm on the left ear (Figures 1 and 2). A shave biopsy was performed (Figures 3 and 4).

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“…The nodules are seen in male patients of preadolescent age, usually appear on the upper eyelid, and are generally asymptomatic. They are usually not related to any systemic disorder, although rheumatologic conditions must be ruled out ( Shields et al, 2016 ).…”

Section: Benign Lesionsmentioning

confidence: 99%