Subepithelial white deposition in the cornea associated with silicone oil and surgical management: a case report

Shao, Yuting; Liu, Xin; Shu, Yiyang; Xiao, Le; Yang, Bi

doi:10.3389/fmed.2023.1147767

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…[ 96 ] These droplets can lead to SO-keratopathy, such as band keratopathy or bullous keratopathy, which prevalence ranges from 7% to 29%. [ 97 ]…”

Section: O Ptical C Oherence T ...mentioning

confidence: 99%

Silicone oil emulsification: A literature review and role of widefield imaging and ultra-widefield imaging with navigated central and peripheral optical coherence tomography technology

Valentín-Bravo,

Stanga,

Reinstein

et al. 2024

Saudi Journal of Ophthalmology

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Silicone oil (SO) emulsification is a significant concern in vitreoretinal surgery, leading to various complications. Despite the high prevalence of SO emulsification within the eye, there is currently no standardized method for its early detection. The recent introduction of widefield (WF) imaging and ultra-WF (UWF) imaging with navigated central and peripheral optical coherence tomography (OCT) techniques have shown promising results in providing high-resolution images of the peripheral vitreous, vitreoretinal interface, retina, and choroid. This enhanced visualization capability enables the early identification of emulsified SO droplets, facilitating a proactive therapeutic approach, and mitigating associated adverse events. This comprehensive literature review aims to provide an updated overview of the topic, focusing on the role of WFimaging and UWF imaging and navigated central and peripheral swept-source OCT (SS-OCT) in the early detection and management of SO emulsification. The review discusses the current understanding of SO emulsification, its associated complications, and the limitations of existing detection methods. In addition, it highlights the potential of WF and UWF imaging and peripheral OCT as advanced imaging modalities for improved visualization of SO emulsification. This review serves as a valuable resource for clinicians and researchers, providing insights into the latest advancements in the field of vitreoretinal surgery and the promising role of WF imaging and UWF imaging and navigated central and peripheral SS-OCT in the management of SO.

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“…[ 96 ] These droplets can lead to SO-keratopathy, such as band keratopathy or bullous keratopathy, which prevalence ranges from 7% to 29%. [ 97 ]…”

Section: O Ptical C Oherence T ...mentioning

confidence: 99%

Silicone oil emulsification: A literature review and role of widefield imaging and ultra-widefield imaging with navigated central and peripheral optical coherence tomography technology

Valentín-Bravo,

Stanga,

Reinstein

et al. 2024

Saudi Journal of Ophthalmology

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Dimeticone

2023

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Multimodal imaging and histopathological evaluation in silicone oil keratopathy

Ferrara,

Forbice,

Segala

et al. 2024

European Journal of Ophthalmology

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Purpose To describe features in silicone oil keratopathy using multimodal imaging and histopathological examination. Methods Case report Result A 21-year-old male developed right corneal decompensation in the heavy SO (HSO)-filled eye. The patient underwent an initial lensectomy, pars plana vitrectomy (PPV) and HSO tamponade due open-globe injury with corneal wound, lens damage and in two retained intravitreal glass foreign bodies, followed by a revisional PPV with HSO tamponade due to tractional detachment associated with proliferative vitreoretinopathy and epiretinal membrane. One month after the removal of HSO, ophthalmic examination of the right eye showed corneal decompensation. The AS-OCT showed corneal thickening, intrastromal scattered hyperreflective dots and large rounded/oval hyporeflective space; the latter were suggestive of emulsified HSO microbubbles and larger bubbles, respectively. In vivo confocal microscopy showed multiple presumed SO-related corneal changes, including hyper-reflective fibrotic changes in the basal epithelium, reduced density ans altered morphology of keratocytes cell population, increased pleomorphism and polymegathism of the endothelium with reduced endothelial cell, and presence of inflammatory cells. The patient underwent a penetrating keratoplasty, pupilloplasty and retropupillary iris-claw IOL implantation. The histopathological examination of the host corneal button showed Descemet's membrane irregularity and thickened corneal stroma with focal intrastromal silicone oil vacuoles, surrounded by macrophages. Conclusion We described for the first time intrastromal hyperreflective dots as a sign associated with SO-related keratopathy. Moreover, this case report supports the ability of emulsified SO to penetrate the cornea inducing a local low-grade chronic inflammation.

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Subepithelial white deposition in the cornea associated with silicone oil and surgical management: a case report

Cited by 3 publications

References 18 publications

Silicone oil emulsification: A literature review and role of widefield imaging and ultra-widefield imaging with navigated central and peripheral optical coherence tomography technology

Silicone oil emulsification: A literature review and role of widefield imaging and ultra-widefield imaging with navigated central and peripheral optical coherence tomography technology

Dimeticone

Multimodal imaging and histopathological evaluation in silicone oil keratopathy

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