2022
DOI: 10.1101/2022.05.03.490441
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Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs in vertebrates

Abstract: The formation of paralogs through gene duplication is a core evolutionary process. For paralogs that encode components of protein complexes such as the ribosome, a central question is whether they encode functionally distinct proteins, or whether they exist to maintain appropriate total expression of equivalent proteins. Here, we systematically tested evolutionary models of paralog function using the mammalian ribosomal protein paralogs eS27 (Rps27) and eS27L (Rps27l) as a case study. We first showed that eS27… Show more

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