Subgaleal and brain abscesses due to Salmonella enteritidis following craniotomy for giant cell glioblastoma multiforme: A case report and literature review

Abstract

Background: Cranial surgical site infections due to Salmonella species are rarely reported. Only eight cases of Salmonella enteritidis infection following intracranial surgery for brain tumor have been reported to date. We describe a unique case of both subgaleal and brain abscesses caused by S. enteritidis following craniotomy for a parafalcine giant cell glioblastoma multiforme. A literature review of the previously published cases is also provided. Case Description: A 36-year-old previously healthy man presented with a posterior parietal parafalcine giant cell glioblastoma multiforme. 5 weeks after craniotomy for tumor resection, the patient presented with worsening headache and painful swelling at the cranial operative site. Head computed tomography and magnetic resonance imaging scans revealed both scalp and brain abscesses in the previous surgical site. He was treated with aspiration of the subgaleal abscess and ciprofloxacin antibiotic therapy; he made a full recovery. Cultures of the aspirate identified S. enteritidis, although the primary site of infection was not detected. Conclusions: Although postoperative S. enteritidis infections are rare, the large numbers of patients with malignant brain tumors who require tumor resections and receive corticosteroids are at great risk. Adequate drainage (if possible), early isolation of the pathogens, and control of the infection by antibiotic therapy guided by antimicrobial susceptibility testing are vital components to prevent this potentially fatal condition.

Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines

“…Furthermore, KEGG pathways for bacterial infection were identified to be deiminated in both GBM cell lines (pathogenic E. coli) but more prominently for LN18 cells (E. coli, salmonella and legionellosis). This may be of relevance for success of using bacterial carriers for glioblastoma therapy [130] as well as for management of bacterial infection following GBM surgery and treatment [131][132][133][134]. Indeed, critical roles for PADs, including pan-PAD and PAD-isozyme specific regulation of bacterial membrane vesicle release, critical for host-pathogen interactions, and in bacterial drug resistance, have recently been described [135].…”

De novo subgaleal abscess complicated by spontaneous osteomyelitis and epidural abscess: a case report and review of literature

“…Potential space allows easy and large collection of blood and other fluids, which can result in complications, such as abscess formation 5 . Subgaleal abscesses usually form after trauma or iatrogenic procedures involving the head, ears, or sinuses 8 , 9 . It can also form due to spread from a nearby structure, such as the skin or sinus, or a hematogenous route 10 .…”

Subgaleal Abscess Following Staphylococcal Cellulitis in a 10-Month-Old Child: A Diagnostic Challenge for the Clinician

“…Staphylococcus aureus has been reported in a subgaleal abscess that follows scalp infections, similar to this child [ 12 ]. Other reported pathogens include Escherichia coli [ 13 ], methicillin-resistant Staphylococcus [ 14 ], Streptococcus pyogenes [ 15 ], Eikenella corrodens [ 16 ], Salmonella enteritidis [ 17 ], and Burkholderia pseudomallei [ 18 ].…”