Subgingival bacterial community profiles in <scp>HIV</scp>‐infected Brazilian adults with chronic periodontitis

Ferreira, Dennis Carvalho; Gonçalves, Lúcio Souza; Siqueira, José F.; Carmo, Flávia Lima do; Feres, Magda; Figueiredo, Lígia; Soares, Geisla Mary Silva; Rosado, Alexandre Soares; Santos, Henrique F.; Colombo, Ana Paula Vieira

doi:10.1111/jre.12287

Cited by 12 publications

(11 citation statements)

References 52 publications

(81 reference statements)

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“…Viral load 19 , CD4 counts 8,9,14 , periodontal status 7,8,20 , and smoking 21 have all been shown to be significant predictors of microbial composition in HIV-positive cohorts. If groups are not balanced, underlying differences among groups on these variables could easily obscure differences that result from HIV status, or lead to misattribution of differences that were not the result of HIV status.…”

Section: Introductionmentioning

confidence: 99%

Significant effect of HIV/HAART on oral microbiota using multivariate analysis

Griffen

Thompson

Beall

et al. 2019

Sci Rep

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Persons infected with HIV are particularly vulnerable to a variety of oral microbial diseases. Although various study designs and detection approaches have been used to compare the oral microbiota of HIV-negative and HIV-positive persons, both with and without highly active antiretroviral therapy (HAART), methods have varied, and results have not been consistent or conclusive. The purpose of the present study was to compare the oral bacterial community composition in HIV-positive persons under HAART to an HIV-negative group using 16S rRNA gene sequence analysis. Extensive clinical data was collected, and efforts were made to balance the groups on clinical variables to minimize confounding. Multivariate analysis was used to assess the independent contribution of HIV status. Eighty-nine HIV-negative participants and 252 HIV-positive participants under HAART were sampled. The independent effect of HIV under HAART on the oral microbiome was statistically significant, but smaller than the effect of gingivitis, periodontal disease, smoking, caries, and other clinical variables. In conclusion, a multivariate comparison of a large sample of persons with HIV under HAART to an HIV-negative control group showed a complex set of clinical features that influenced oral bacterial community composition, including the presence of HIV under HAART.

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Section: Introductionmentioning

confidence: 99%

Significant effect of HIV/HAART on oral microbiota using multivariate analysis

Griffen

Thompson

Beall

et al. 2019

Sci Rep

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“…[19] Moreover, an independent study revealed increased diversity in subgingival biofilms of HIV+ individuals within a Brazilian cohort of 32 subjects with PD. [20] …”

Section: Introductionmentioning

confidence: 99%

Oral microbiome in HIV-associated periodontitis

et al. 2017

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“…Ferreira et al (2016) have demonstrated that HIV-1-infected patients have significantly less visible supragingival plaque, as well as less periodontal inflammation and tissue destruction compared with non-HIV-1-infected patients [ 39 ]. The periodontal clinical parameters were also less severe in these HIV-infected patients than in non-HIV-1-infected patients, confirming previous data reported by other studies on the same population [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Stage II and stage III periodontitis clinical burdens of HIV-1 undergoing antiretroviral therapy

et al. 2021

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Objectives The aim of this retrospective cross-sectional study was to estimate the association of HIV-1 infection under highly active antiretroviral treatment (HAART) on the clinical parameters of periodontitis. Materials and methods A total of 205 patients were divided in two groups: 74 HIV + and 131 HIV − . Periodontal probing depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and visible supragingival biofilm (VSB) were recorded. The association of HIV-1 infection with the presence of at least 3 sites with PPD ≥ 5 mm and/or CAL ≥ 4 mm in non-adjacent teeth was estimated using binary logistic regression models. Results The variables HIV-1 infection (OR = 5.53, p < 0.0001, 95% CI: 2.45–13.64), age [range 35–50 years old (OR = 5.73, p < 0.0001, 95% CI: 2.49–13.20); > 50 years old (OR = 6.29, p = 0.002, 95% CI: 1.94–20.42)], and VSB (OR = 23.68, p < 0.0001, 95% CI: 8.07–69.53) showed a significant direct association with BOP outcome. Conclusions HIV-1 infection under HAART did not have association with the presence of at least 3 sites with PPD ≥ 5 mm and/or CAL ≥ 4 mm. However, HIV patients on HAART had direct association of HIV-1 infection with BOP and an inverse association with PPD. Clinical relevance These results support that monitoring gingival bleeding associated with oral prophylaxis would be beneficial in the prevention and management of periodontitis in HIV-1 patients on HAART.

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Subgingival bacterial community profiles in HIV‐infected Brazilian adults with chronic periodontitis

Abstract: HIV-infected patients with chronic periodontitis present greater subgingival microbial diversity. In addition, the bacterial communities associated with HIV-infected and non-HIV-infected individuals are different in structure.

Cited by 12 publications

References 52 publications

Significant effect of HIV/HAART on oral microbiota using multivariate analysis

Significant effect of HIV/HAART on oral microbiota using multivariate analysis

Oral microbiome in HIV-associated periodontitis

Stage II and stage III periodontitis clinical burdens of HIV-1 undergoing antiretroviral therapy

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