Subgingivally delivered coenzyme Q10 in the treatment of chronic periodontitis among smokers: A randomized, controlled clinical study

Abstract

Background: Coenzyme Q10 is an antioxidant whose efficacy in periodontal diseases is well known. However studies regarding its efficacy in smokers with periodontitis are few. Coenzyme Q10 serves as an endogenous antioxidant and its increased concentration in the diseased gingiva effectively suppresses advanced periodontal inflammation.Objectives: The aim of this study is to evaluate the efficacy of coenzyme Q10 as an adjunct to scaling and root planing in smokers with chronic periodontitis. Methods: Total of 40 patients were enrolled for the study. The subjects were divided into control (Scaling and root planing only) and test group (Coenzyme Q10 plus Scaling and root planing). Clinical parameters such as plaque index, modified sulcular bleeding index, probing pocket depth and clinical attachment level. These were assessed at baseline, at 1 month and 3 month. The results were subjected to appropriate statistical analysis. Results: There was a significant improvement in all clinical parameters in the test sites seen at the end of the 1 month and 3 month period. Conclusions: Coenzyme Q10 can be said to have a beneficial effect on smokers with periodontitis when used as an adjunct to scaling and root planing.

The Effect of Coenzyme Q10/Collagen Hydrogel on Bone Regeneration in Extraction Socket Prior to Implant Placement in Type II Diabetic Patients: A Randomized Controlled Clinical Trial

“…Although similar in structure to vitamin K, CoQ10 is not a vitamin since it is naturally synthesized in every cell in the human body, whereas vitamins must be obtained from the diet [ 45 , 46 ]. Some studies have investigated the effects of CoQ10 in diabetes being a safe material with very low toxicity [ 47 , 48 , 49 ] while other studies have shown that oral application of CoQ10 is effective in improving periodontitis [ 50 , 51 , 52 , 53 ]. However, the local effect of CoQ10 in bone regeneration and healing of extraction sockets in humans have not been previously studied.…”

Comparative evaluation of efficacy of topical and intra-sulcular application of Co-enzyme Q10 in the non-surgical treatment of periodontal diseases

“…A study by Raut et al . [ 15 ] compared the evaluation of CoQ gel and Melaleuca alternifolia (tea tree oil) and concluded that both of these agents have equal effective antioxidant property, but not superior to SRP alone. Another study by Sharma et al .…”

Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial

“…This double action of CoQ10 could be the reason for its effect being equivalent to that of triamcinolone. Topical CoQ10 has been previously investigated in other oral conditions, such as periodontal and gingival conditions and showed a great clinical reduction in the in ammatory condition after a few weeks (Prakash et 2010, Darweesh et al, 2015, Raut et al, 2019, Pranam et al 2020.…”