Subgroup studies of black admixture within a mixed population of Bahia, Brazil

Azevêdo, Eliane S.

doi:10.1111/j.1469-1809.1980.tb00945.x

Cited by 70 publications

(46 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The high contribution of Africans to the gene pool of our African descent sample of Jequié differs from that seen in previous studies of northeastern Brazilian populations (Callegari-Jacques et al 2003; Ferreira et al 2005), possibly due to the careful choice of African-descendants by the morphological ethnic classification (Azevêdo, 1980) used in our study.…”

Section: Resultscontrasting

confidence: 56%

“…There were no individuals classified as Amerindian or Caucasian by phenotype in this commuStudies in an African-descendant isolate 25 Sources: (1) Africans - (Deka et al, 1999;Destro-Bisol et al, 2000;Huguet et al, 1998;Bosh et al, 2001;Gene et al, 2001;Alves et al, 2001;Brinkmann et al, 1996;Brinkmann et al, 1998;Rolf et al, 1998;Wang et al, 2002;Pérez-Lezaun et al, 1997;Yunis et al, 2000;Corte-Real et al, 2000;Dios et al, 1998); (2) Europeans (Pérez- Lezaun et al, 2000;Anjos et al, 2000;Lourdes-Pontes et al, 1998;Asmundo et al, 1998;Santos et al, 1996;Souto et al, 1996, Souto et al, 1998Alves et al, 2001;Pinheiro et al, 1996;Amorim et al, 1996;Pereira et al, 1996;Gusmão et al, 1997;Espinheira et al, 1996;Miranda et al, 1998;Prata et al, 1998) nity. This date on phenotypic ethnic classification is based on facial morphological characteristics and skin color in body regions not exposed to the sun (Azevêdo, 1980). As regards anthropologic characteristics, the Bananal community NCI was 0.24, a median value compared to that expected for an African derived population (Azevêdo et al,1982), possibly due to a founder effect related to the fact that few surnames with religious connotation were present in the initial composition of the community.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

et al. 2006

View full text Add to dashboard Cite

The African descent population of the Bananal community in the Brazilian state of Bahia (BA) was characterized as a genetic isolate and analyzed for some short tandem repeat (STR) microsatellite autosomic polymorphic loci (CSF1PO, TH01, TPOX, F13A1, FESFPS and vWA). These genetic variants were further compared to data obtained from an urban sample from the town of Jequié (BA) regarding demographic and anthropogenetic aspects. The Bananal sample comprised 32 unrelated individuals whereas Jequié was represented by 76 individuals. The Bananal Negroid Phenotypic Index (NPI) was 0.98 and the Negroid Cultural Index (NCI) 0.24. Consanguineous marriages occurred at a frequency of 34.61% and the F value was 0.0126. All six loci studied were in Hardy-Weinberg Equilibrium (p > 0.05). The genotypic and allele frequencies of the CSF1PO and vWA loci were similar. In the Bananal population the genic diversity of the THO1 locus was 66.8% and that of the F13A1 locus was 83.7%. The estimated ethnic racial admixture was 81% African and 19% Amerindian. The multiple correlation coefficient (R 2 ) indicated adequate adaptation (99%). Total genetic variation for the six loci was 82.9% with an index of 6.7% for population subdivision (G ST ' = 0.067). Anthropologic data and results obtained from the allele frequencies of the loci studied are indicative of a genetic isolate in Bananal, reminiscent of the a`quilombo community' (i.e. one founded by run away slaves).

show abstract

Section: Resultscontrasting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Among the additional information collected for the classification the low frequency of patients with a family history of Crohn's disease may be explained by the difficulty in analyzing this variable since many patients do not have this information about their family members or perhaps the disease is misdiagnosed. In spite of the high number of Afro-descendant patients, the distribution of the different racial groups (71% of mulattos, 16% of whites and 13% of blacks) was similar to the distribution of the population of the State of Bahia, Brazil (1) . Perhaps the disease among us does not show any difference in its frequency among the racial groups.…”

Section: Resultsmentioning

confidence: 99%

“…Race was described as white, mulatto and black by subjective evaluation based on established criteria by KRIEGER et al (8) and modified by AZEVÊDO (1) . All patients with Crohn's disease evaluated at the study period were included in the study.…”

Section: Methodsmentioning

confidence: 99%

Application of the Vienna classification for Crohn’s disease to a single center from Brazil

Santana

Souza

Azevedo

et al. 2008

Arq. Gastroenterol.

View full text Add to dashboard Cite

BACKGROUND: Crohn’s disease is a chronic inflammatory disorder with diversity on its clinical presentation that may be observed from the varying age of onset of symptoms to the site of occurrence of the illness. There is a need for a replicable and uniform description of the disease allowing a comparison between distinct study populations. The 1998 Vienna classification characterizes patients according to three clinical aspects: age at diagnosis, location and disease behavior. AIM: To describe Crohn’s disease in patients from a reference center of Salvador, BA, Brazil according to the Vienna classification. METHODS: Between January and October of 2005, patients (n = 47) having at least one endoscopic and radiological examination of the intestine participated in this study. RESULTS: Most of the participants had the diagnosis of the disease when they were younger than 40 years old (70.2%) while an ileocolic location (38.3%) and the penetrating form (46.8%) were the most prevalent clinical presentation. The restricted location of the ileum (L1) was more frequent in nonstricturing, nonpenetrating disease (B1) while the ileocolic disease (L3) was more associated with the penetrating behavior (B3). CONCLUSION: In this study, differently from the first description of the Vienna classification, the large number of patients presenting a complicated stage of the disease can be attributed to the fact that it was carried out at a reference center, where many patients present with the disease at an advanced stage.

show abstract

“…Therefore, in order to compare patients from different ethnic background they were classified as Caucasians (C) or African/Brazilian (A/B) according to the criteria published in Azevedo. 19 No patient in the present sample was Oriental (although in São Paulo there are 1 000 000 Brazilian/Japanese).…”

Section: Subjectmentioning

confidence: 99%

Clinical variability in calpainopathy: What makes the difference?

et al. 2002

View full text Add to dashboard Cite

Limb girdle muscular dystrophies (LGMD) are a heterogeneous group of genetic disorders characterised by progressive weakness of the pelvic and shoulder girdle muscles and a great variability in clinical course.LGMD2A, the most prevalent form of LGMD, is caused by mutations in the calpain-3 gene (CAPN-3). More than 100 pathogenic mutations have been identified to date, however few genotype : phenotype correlation studies, including both DNA and protein analysis, have been reported. In this study we screened 26 unrelated LGMD2A Brazilian families (75 patients) through Single-Stranded Conformation Polymorphism (SSCP), Denaturing high-performance liquid chromatography (DHPLC) and sequencing of abnormal fragments which allowed the identification of 47 mutated alleles (approximately 90%). We identified two recurrent mutations (R110X and 2362-2363AG4TCATCT) and seven novel pathogenic mutations. Interestingly, 41 of the identified mutations (approximately 80%) were concentrated in only 6 exons (1, 2, 4, 5, 11 and 22), which has important implications for diagnostic purposes. Protein analysis, performed in 28 patients from 25 unrelated families showed that with exception of one patient (with normal/slight borderline reduction of calpain) all others had total or partial calpain deficiency. The effects of type of mutation, amount of calpain in the muscle, gender and ethnicity of affected patients on clinical course (age of onset and ascertainment) were analysed. Interestingly, it was observed that, on average, African -Brazilian calpainopathy patients are more severely affected than Caucasians.

show abstract

Subgroup studies of black admixture within a mixed population of Bahia, Brazil

Cited by 70 publications

References 6 publications

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

Application of the Vienna classification for Crohn’s disease to a single center from Brazil

Clinical variability in calpainopathy: What makes the difference?

Contact Info

Product

Resources

About