Subject-specific finite element models implementing a maximum principal strain criterion are able to estimate failure risk and fracture location on human femurs tested in vitro

Schileo, Enrico; Taddei, Fulvia; Cristofolini, Luca; Viceconti, Marco

doi:10.1016/j.jbiomech.2007.09.009

Cited by 321 publications

(252 citation statements)

References 46 publications

(81 reference statements)

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“…The results also showed that application of a strain-based failure criterion improved the prediction of the failure load. Similar to Lotz et al, Schileo et al (2008) found that strain-based criteria resulted in a better prediction of the fracture onset and the level of failure risk. These results seem obvious, as it is generally accepted that strain parameters describe bone failure.…”

Section: (A ) Fe Meshsupporting

confidence: 66%

Multi-level patient-specific modelling of the proximal femur. A promising tool to quantify the effect of osteoporosis treatment

Lenaerts

Lenthe

2009

Phil. Trans. R. Soc. A.

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Preventing femoral fractures is an important goal in osteoporosis research. In order to evaluate a person's fracture risk and to quantify response to treatment, bone competence is best assessed by bone strength. Finite-element (FE) modelling based on medical imaging is considered a very promising technique for the assessment of in vivo femoral bone strength. Over the past decades, a number of different FE models have been presented focusing on the effect of several methodological aspects, such as mesh type, material properties and loading conditions, on the precision and accuracy of these models. In this paper, a review of this work is presented. We conclude that moderate to good predictions can be made, especially when the models are tuned to specific loading scenarios. However, there is room for improvement when multiple loading conditions need to be evaluated. We hypothesize that including anisotropic material properties is the first target. As a proof of the concept, we demonstrate that the main orientation of the femoral bone structure can be calculated from clinical computed tomography scans. We hypothesize that this structural information can be used to estimate the anisotropic bone material properties, and that in the future this could potentially lead to a greater predictive value of FE models for femoral bone strength.

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Section: (A ) Fe Meshsupporting

confidence: 66%

Multi-level patient-specific modelling of the proximal femur. A promising tool to quantify the effect of osteoporosis treatment

Lenaerts

Lenthe

2009

Phil. Trans. R. Soc. A.

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“…The magnitude of the yield load was predicted with a moderate accuracy in these studies, and shown to be inferior to the strain-based criterion in Schileo et al (2008) using isotropic material properties. As expected, for the loading condition prescribed, the regions under tension are under a very large tensile stress, which implies yielding in tension and not in compression.…”

Section: Discussionmentioning

confidence: 86%

“…In table 1 we summarize the yield load predicted by the orthotropic and isotropic FE models. Indeed the strain criterion is the most appropriate (a conclusion isotropic 5600 (3) 5500 (3) 6500 (3) 4110 (3) 4200-4800 4100 (5) 4000 (5) 4800 (5) 5500 (4) anisotropic 4000 (4) 4000 (4) 5000 (4) 4800 (3) 4200-4800 3100 (4) 3000 (4) 3600 (4) 4400 (4) supported by Schileo et al (2008) also) for yield load prediction. This criterion also predicts well the location at which the fracture initiates when compared with the single available experimental result.…”

Section: Discussionmentioning

confidence: 99%

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Predicting the yield of the proximal femur using high-order finite-element analysis with inhomogeneous orthotropic material properties

Yosibash

Tománek

Trabelsi

2010

Phil. Trans. R. Soc. A.

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High-order finite-element (FE) analyses with inhomogeneous isotropic material properties have been shown to predict the strains and displacements on the surface of the proximal femur with high accuracy when compared with in vitro experiments. The same FE models with inhomogeneous orthotropic material properties produce results similar to those obtained with isotropic material properties. Herein, we investigate the yield prediction capabilities of these models using four different yield criteria, and the spread in the predicted load between the isotropic and orthotropic material models. Subjectspecific high-order FE models of two human femurs were generated from CT scans with inhomogeneous orthotropic or isotropic material properties, and loaded by a simple compression force at the head. Computed strains and stresses by both the orthotropic and isotropic FE models were used to determine the load that predicts 'yielding' by four different 'yield criteria': von Mises, Drucker-Prager, maximum principal stress and maximum principal strain. One of the femurs was loaded by a simple load until fracture, and the force resulting in yielding was compared with the FE predicted force. The surface average of the 'maximum principal strain' criterion in conjunction with the orthotropic FE model best predicts both the yield force and fracture location compared with other criteria. There is a non-negligible influence on the predictions if orthotropic or isotropic material properties are applied to the FE model. All stress-based investigated 'yield criteria' have a small spread in the predicted failure. Because only one experiment was performed with a rather simplified loading configuration, the conclusions of this work cannot be claimed to be either reliable or sufficient, and future experiments should be performed to further substantiate the conclusions.

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“…Several studies showed that bone exhibits a quasi-brittle material behavior [5,14,16,[32][33][34]62] or brittle behavior [31,43,68,88] depending mainly on the deformation rate applied and the bone properties. Therefore, more suitable physical models are still lacking to describe the brittle to quasi-brittle fracture behavior of human femur.…”

Section: Previous Fe Models Have Applied Different Uncoupled Fracturementioning

confidence: 99%

A quasi-brittle continuum damage finite element model of the human proximal femur based on element deletion

Hambli

2012

Med Biol Eng Comput

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Subject-specific finite element models implementing a maximum principal strain criterion are able to estimate failure risk and fracture location on human femurs tested in vitro

Cited by 321 publications

References 46 publications

Multi-level patient-specific modelling of the proximal femur. A promising tool to quantify the effect of osteoporosis treatment

Multi-level patient-specific modelling of the proximal femur. A promising tool to quantify the effect of osteoporosis treatment

Predicting the yield of the proximal femur using high-order finite-element analysis with inhomogeneous orthotropic material properties

A quasi-brittle continuum damage finite element model of the human proximal femur based on element deletion

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