Subject-specific mechanical properties of vertebral cancellous bone assessed using a low-dose X-ray device

Brosses, Emilie Sapin - de; Briot, Karine; Kolta, Sami; Skalli, Wafa; Roux, Christian; Mitton, David

doi:10.1016/j.irbm.2010.02.014

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…Briefly, the vertebrae were radiographed in antero-posterior and lateral view with the EOS low dose imaging system (EOS imaging, Paris, France), at two different energy levels (70 kVp-250 mA and 120 kVp-250 mA). From these biplanar radiographs, the 3D geometry and the areal BMD were calculated for each vertebra with specific softwares [12,26]. A subjectspecific mesh was built using geometric parameters computed on the 3D reconstructions [27].…”

Section: Vertebral Modelmentioning

confidence: 99%

“…1). In the present study, different Young's moduli were considered for the sensitivity study in a range of values corresponding to the physiologic material properties previously assessed [20,26]. The Poisson's ratio was set to 0.3.…”

Section: Vertebral Modelmentioning

confidence: 99%

“…Three other parameters with two values per parameters were considered: Young's modulus of TB and CTB, and load location. Low and high values for TB and CTB Young's modulus were chosen according to previous experiments on TB and CTB samples [20,26]. The mean ±0.5 SD of the value of the corresponding medium were considered as low and high modulus, to allow a sufficient range of variation, and to avoid too unrealistic conditions.…”

Section: Sensitivity Studymentioning

confidence: 99%

“…A subject-specific finite element model using a smooth geometry issued from low dose biplanar radiography, such as Dual X-ray Absorptiometry (DXA) [16,17] and the EOS system, and personalized material properties from BMD [26] has shown promising results in predicting vertebral strength in anterior bending (R 2 = 0.79, root mean square error = 367 N) [27]. A very good approximation of geometry can now be attained in a short reconstruction time from biplanar radiographs (1 mm shape accuracy [12]).…”

Section: Introductionmentioning

confidence: 99%

“…A very good approximation of geometry can now be attained in a short reconstruction time from biplanar radiographs (1 mm shape accuracy [12]). Material properties evaluation from this imaging technique is however not as detailed as CT-scan [26]. This approach raises another question: What accuracy in vertebral's material properties should be reached?…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Sensitivity of patient-specific vertebral finite element model from low dose imaging to material properties and loading conditions

Travert

Jolivet

Brosses

et al. 2011

Med Biol Eng Comput

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Patient-specific modeling could help in predicting vertebral osteoporotic fracture. The accuracy requirement for input data available in clinical routine is related to the model sensitivity. The objective of this study is to assess the relative impact of material properties and of loading conditions on vertebral strength using a finite element model. Fourteen subject-specific vertebral finite element models were used to investigate the effect of material properties and loading conditions. A design of experiment was set to study three parameters: Young's moduli of trabecular bone and cortico-trabecular bone (outer 3 mm of the vertebra), and load location. Cortico-trabecular bone modulus variation from 270 to 478 MPa made fracture load vary from 22 to 51%, depending on other parameters. Trabecular bone modulus variation from 115 to 258 MPa made fracture load vary from 11 to 43%. Displacing load location by 1 cm resulted in a mean decrease of 48-60% of the fracture load. Anterior bending induced strain concentration in vertebral anterior wall. Material properties of both type of bone have about the same effect. Load location is the most sensitive. Effort should be made to take into account patients' specific load distribution regarding its sagittal balance, in addition to bone properties.

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Section: Vertebral Modelmentioning

confidence: 99%

Section: Vertebral Modelmentioning

confidence: 99%

Section: Sensitivity Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sensitivity of patient-specific vertebral finite element model from low dose imaging to material properties and loading conditions

Travert

Jolivet

Brosses

et al. 2011

Med Biol Eng Comput

View full text Add to dashboard Cite

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Biomechanics of Bone Tissue and Its Interactions with Surrounding Tissues

SAPIN‐DE BROSSES,

MITTON

2024

Mechanics of Living Tissues

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Apparent Young's modulus of vertebral cortico-cancellous bone specimens

Masri

Brosses

Rhissassi

et al. 2012

Computer Methods in Biomechanics and Biomedical Engineering

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Up to now, due to cortical thickness and imaging resolution, it is not possible to derive subject-specific mechanical properties on the 'vertebral shell' from imaging modalities applicable in vivo. As a first step, the goal of this study was to assess the apparent Young's modulus of vertebral cortico-cancellous bone specimens using an inverse method. A total of 22 cortico-cancellous specimens were harvested from 22 vertebral bodies. All specimens were tested in compression until failure. To compute the apparent Young's modulus of the specimen from the inverse method, the boundary conditions of the biomechanical experiments were faithfully reproduced in a finite element model (FEM), and an optimisation routine was used. The results showed a mean of the apparent Young's modulus of 374 ± 208 MPa, ranging from 87 to 791 MPa. By computing an apparent Young's modulus of a cortico-cancellous medium, this study gives mechanical data for an FEM of an entire vertebra including an external shell combining both bone tissues.

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Subject-specific mechanical properties of vertebral cancellous bone assessed using a low-dose X-ray device

Cited by 6 publications

References 32 publications

Sensitivity of patient-specific vertebral finite element model from low dose imaging to material properties and loading conditions

Sensitivity of patient-specific vertebral finite element model from low dose imaging to material properties and loading conditions

Biomechanics of Bone Tissue and Its Interactions with Surrounding Tissues

Apparent Young's modulus of vertebral cortico-cancellous bone specimens

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