Climate change is one of the biggest threats to human health and well‐being. This entry summarizes direct and indirect impacts of climate change on public health. It then reviews evidence of public knowledge and media attention to climate change as a public health issue. It evaluates the effectiveness of communicating health impacts of climate change to foster public attention and engagement. It concludes by focusing on challenges and opportunities for health communication scholars to help communicate climate change, which is also the single biggest opportunity of the twenty‐first century to achieve equitable progress on improving global health outcomes.