Subjective cancer-related cognitive impairments and salience network connectivity in breast cancer survivors

Henneghan, Ashley M.; Kesler, Shelli R.

doi:10.1007/s11764-022-01307-8

Cited by 5 publications

(5 citation statements)

References 52 publications

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“…Microstate C has been associated with the salience resting state network as well as functional areas associated with self-referential thought 36,38 . This finding adds a new perspective to the viewpoint that salience network connectivity changes can serve as an objective biomarker for cognitive impairments due to chemotherapy in breast cancer survivors 7 . Microstate F, on the other hand, demonstrated a large decrease in mean occurrence post-chemotherapy relative to baseline.…”

Section: Discussionmentioning

confidence: 70%

“…Microstate D has been shown to primarily be associated with the attention, orientation, and executive function RSN (e.g., activity in the right inferior parietal lobe and the right middle and superior frontal gyri) 19,36 . Attention and executive functions are especially impaired in patients with breast cancer following chemotherapy treatment 3,7 . A disruption in these cognitive functions maps especially well onto symptoms of mental fatigue, difficulties with attention and memory impairment 6 .…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy-related cognitive impairment (CRCI), colloquially referred to as "chemo brain" or "chemo fog", is a cluster of cognitive impairments including mental fatigue, attentional problems, and memory complaints [1][2][3][4][5] . Breast cancer survivors who have completed chemotherapy treatment report greater cognitive concerns post-treatment relative to pretreatment, as well as greater executive dysfunction and impaired memory compared with matched healthy controls 6,7 . The neurophysiological correlates of CRCI remain unknown and currently there is no accepted "brain signature" of CRCI, making it difficult to develop strategies to manage this issue 7 .…”

Section: Introductionmentioning

confidence: 96%

“…Breast cancer survivors who have completed chemotherapy treatment report greater cognitive concerns post-treatment relative to pretreatment, as well as greater executive dysfunction and impaired memory compared with matched healthy controls 6,7 . The neurophysiological correlates of CRCI remain unknown and currently there is no accepted "brain signature" of CRCI, making it difficult to develop strategies to manage this issue 7 .…”

Section: Introductionmentioning

confidence: 96%

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Changes in EEG microstate dynamics and cognition post-chemotherapy in people with breast cancer: A pilot study

Damji,

Sattari,

Zadravec

et al. 2024

Preprint

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Objective: Chemotherapy-related cognitive changes following breast cancer are commonly reported; however, changes in brain dynamics of large-scale neural networks remain unclear. Using data from the Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial, we conducted exploratory analyses to compare self-reported and objective measures of cognition and applied microstate analysis to resting state electroencephalography (EEG) data of women with breast cancer before and following chemotherapy treatment. Methods: Data from 8 female participants between the ages of 30 and 52 (mean age = 44.8 yrs, SD = 7.3 yrs) were analyzed. Cognitive function was assessed using the PROMIS (Patient-Reported Outcomes Measurement Information System) and the Trail Making Test (TMT). Five minutes of resting state, eyes-closed EEG data were also collected. Seven EEG microstates were extracted and mean microstate duration and occurrence were computed. Results: Following chemotherapy, there was a significant decrease in the PROMIS score (p = 0.003, d = 1.601), but no significant difference in the TMT. Overall, durations of microstates were significantly longer (p < 0.001, d = 2.837) and less evenly distributed following chemotherapy. The mean duration of microstate D significantly increased following chemotherapy (p = 0.007, d = 1.339). No significant correlations between microstate features and the PROMIS score were observed. Conclusions: We observed self-reported cognitive impairment and disturbed functional dynamics in the resting state brain following chemotherapy treatment. These results introduce a potential novel biomarker to evaluate the changes in large scale brain dynamics related to the cognitive effects of chemotherapy.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Changes in EEG microstate dynamics and cognition post-chemotherapy in people with breast cancer: A pilot study

Damji,

Sattari,

Zadravec

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Resting state fMRI functional connectivity studies provide insight regarding the brain network’s organization in terms of parallel information processing. Some studies show diffuse hyperconnectivity in chemotherapy exposed breast cancer patients and survivors compared to controls ( 88 , 100 , 101 ) while others have shown hypoconnectivity ( 45 , 102–106 ). Given the brain’s vast complexity, the interpretation of hyper- vs. hypo- activation/connectivity is difficult especially since both can exist simultaneously.…”

Section: Crci Is a Brain-based Disordermentioning

confidence: 99%

Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment

Kesler,

Henneghan,

Prinsloo

et al. 2023

Front. Med.

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Cancer related cognitive impairment (CRCI) is commonly associated with cancer and its treatments, yet the present binary diagnostic approach fails to capture the full spectrum of this syndrome. Cognitive function is highly complex and exists on a continuum that is poorly characterized by dichotomous categories. Advanced statistical methodologies applied to symptom assessments have demonstrated that there are multiple subclasses of CRCI. However, studies suggest that relying on symptom assessments alone may fail to account for significant differences in the neural mechanisms that underlie a specific cognitive phenotype. Treatment plans that address the specific physiologic mechanisms involved in an individual patient’s condition is the heart of precision medicine. In this narrative review, we discuss how biotyping, a precision medicine framework being utilized in other mental disorders, could be applied to CRCI. Specifically, we discuss how neuroimaging can be used to determine biotypes of CRCI, which allow for increased precision in prediction and diagnosis of CRCI via biologic mechanistic data. Biotypes may also provide more precise clinical endpoints for intervention trials. Biotyping could be made more feasible with proxy imaging technologies or liquid biomarkers. Large cross-sectional phenotyping studies are needed in addition to evaluation of longitudinal trajectories, and data sharing/pooling is highly feasible with currently available digital infrastructures.

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The Mediating Effect of Coping Style in the Relationship Between Sleep Quality and Perceived Cognitive Impairment Among Breast Cancer Patients

Chen,

Li,

Zhu

et al. 2024

Cancer Nurs

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Background Perceived cognitive impairment is a significant symptom experienced by breast cancer patients and may be affected by sleep quality. Coping styles have potential relevancies with both sleep quality and perceived cognitive impairment. However, the empirical evidence supporting their association among breast cancer patients is limited. Objective This study explored the associations between sleep quality, coping styles, and perceived cognitive impairment and tested the mediating role of coping styles in breast cancer patients. Methods A total of 294 breast cancer patients were included in this cross-sectional study. Patients were assessed using the Pittsburgh Sleep Index Scale, the Simplified Coping Styles Questionnaire, and the Functional Assessment of Cancer Therapy-Cognitive Functioning (Version 3) Scale. The data were analyzed using SPSS and Process macros. Results The direct effect of sleep quality on reported cognitive impairment was significant (β = −0.245, P < .001). Furthermore, sleep quality was found to have a significant indirect effect on perceived cognitive impairment through positive coping style (β = −0.026, P < .05) and negative coping style (β = −0.131, P < .05). Conclusions Our research suggests that sleep quality has both a direct effect on perceived cognitive impairment and an indirect effect through positive and negative coping styles in breast cancer patients. Moreover, negative coping style had a more pronounced mediating effect than positive coping style. Implications for Practice Clinical medical staff could reduce the perceived cognitive impairment of breast cancer patients by improving their sleep quality and encouraging them to adopt a more positive coping style.

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Subjective cancer-related cognitive impairments and salience network connectivity in breast cancer survivors

Cited by 5 publications

References 52 publications

Changes in EEG microstate dynamics and cognition post-chemotherapy in people with breast cancer: A pilot study

Changes in EEG microstate dynamics and cognition post-chemotherapy in people with breast cancer: A pilot study

Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment

The Mediating Effect of Coping Style in the Relationship Between Sleep Quality and Perceived Cognitive Impairment Among Breast Cancer Patients

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