Subjective cognitive complaints and amyloid burden in cognitively normal older individuals

Amariglio, Rebecca E.; Becker, J. Alex; Carmasin, Jeremy; Wadsworth, Lauren P.; Lorius, Natacha; Sullivan, Caroline; Maye, Jacqueline; Gidicsin, Christopher; Pepin, Lesley; Sperling, Reisa A.; Johnson, Keith A.; Rentz, Dorene M.

doi:10.1016/j.neuropsychologia.2012.08.011

Cited by 418 publications

(380 citation statements)

References 64 publications

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“…Moreover, the presence of amyloid brain lesions was associated with a low cognitive awareness in our participants. 34 This result may appear in contradiction with some recent data 56 but it is noteworthy that the subjects were only complainers and did not fully correspond to the definition of subjective cognitive decline 57 . However, an extensive investigation of their subjective feelings was performed, and to our knowledge, INSIGHT-preAD is the first study with such a comprehensive evaluation of different aspects of cognitive complaints, including 6 questionnaires with a total of 88 items all of which administered with the same investigators in participants who were cognitively healthy at study entry.…”

Section: Discussioncontrasting

confidence: 91%

Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study

Dubois

Epelbaum

Nyasse

et al. 2018

The Lancet Neurology

186

207

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Section: Discussioncontrasting

confidence: 91%

Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study

Dubois

Epelbaum

Nyasse

et al. 2018

The Lancet Neurology

186

207

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“…Recent research correlates the presence of SMC and biomarkers including brain region volumes, [24][25][26] amyloid burden, 26 brain atrophy, 9 and gray matter atrophy, 27 and is consistent with earlier neuropathologic reports. 13,28 In this study, neuropathology was obtained on a large proportion of participants who died.…”

Section: 6supporting

confidence: 87%

Self-reported memory complaints

et al. 2014

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Objective: We assessed salience of subjective memory complaints (SMCs) by older individuals as a predictor of subsequent cognitive impairment while accounting for risk factors and eventual neuropathologies.Methods: Subjects (n 5 531) enrolled while cognitively intact at the University of Kentucky were asked annually if they perceived changes in memory since their last visit. A multistate model estimated when transition to impairment occurred while adjusting for intervening death. Risk factors affecting the timing and probability of an impairment were identified. The association between SMCs and Alzheimer-type neuropathology was assessed from autopsies (n 5 243).Results: SMCs were reported by more than half (55.7%) of the cohort, and were associated with increased risk of impairment (unadjusted odds ratio 5 2.8, p , 0.0001). Mild cognitive impairment (dementia) occurred 9.2 (12.1) years after SMC. Multistate modeling showed that SMC reporters with an APOE e4 allele had double the odds of impairment (adjusted odds ratio 5 2.2, p 5 0.036). SMC smokers took less time to transition to mild cognitive impairment, while SMC hormone-replaced women took longer to transition directly to dementia. Among participants (n 5 176) who died without a diagnosed clinical impairment, SMCs were associated with elevated neuritic amyloid plaques in the neocortex and medial temporal lobe.Conclusion: SMC reporters are at a higher risk of future cognitive impairment and have higher levels of Alzheimer-type brain pathology even when impairment does not occur. As potential harbingers of future cognitive decline, physicians should query and monitor SMCs from their older patients. Neurology ® 2014;83:1359-1365 GLOSSARY AD 5 Alzheimer disease; BRAiNS 5 Biologically Resilient Adults in Neurological Studies; CERAD 5 Consortium to Establish a Registry for Alzheimer's Disease; HRT 5 hormone replacement therapy; MCI 5 mild cognitive impairment; MTL 5 medial temporal lobe; NFT 5 neurofibrillary tangle; NP 5 neuritic plaque; NSI 5 no serious impairment; OR 5 odds ratio; SMC 5 subjective memory complaint.Subjective memory complaints (SMCs) may signal increased risk of progression into clinically recognized states of impairment, namely, mild cognitive impairment (MCI) and dementia. [1][2][3][4][5] Although prior studies use incident dementia as an endpoint, there is a need to consider the effect of SMC on the occurrence of MCI as well. 6 Little is known about risk factors associated with the occurrence of SMCs other than depression or poor psychological well-being.7 SMCs may reflect aspects of metamemory, as older adults monitor their own forgetting.8 Persons with SMC may show MRI-based hippocampal atrophy, a finding also seen in MCI.9 Finally, while Alzheimer disease (AD)-type neuropathologic changes occur years before clinical symptoms are detectable, only a few studies link SMC to neuropathology 10,11 or to biomarkers. 2We hypothesized that baseline cognitively intact subjects who declared an SMC would be at a higher risk of a cognitive impa...

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“…by guest on May 10, 2018 http://stroke.ahajournals.org/ Downloaded from same study, no association was found between objective memory measures and amyloid burden. 31 Thus, the deposition of amyloid-β proteins in the vessels of the brain can compromise their integrity, which may lead to leakage and subsequently contribute to clinical stroke. 32 We found that the association between subjective memory complaints and stroke was strongest in highly educated persons.…”

Section: Discussionmentioning

confidence: 99%

Subjective Memory Complaints and the Risk of Stroke

Sajjad

Mirza

Portegies

et al. 2015

Stroke

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This study was embedded in the Rotterdam Study, a large prospective population-based cohort that started in 1990 among inhabitants aged ≥55 years residing in a district of Rotterdam, the Netherlands Background and Purpose-Persons with cognitive impairment, as assessed by cognitive tests, are at a higher risk of stroke.Subjective memory complaints might be an earlier marker for stroke, especially in persons with higher education. Their cognitive reserve might mask their cognitive impairment during cognitive testing. In a population-based setting, we investigated the association between subjective memory complaints and stroke. We simultaneously investigated the association between Mini-Mental State Examination and stroke. We also assessed whether these associations varied with educational level. Methods-9152 participants from the Rotterdam Study (baseline 1990-1993 or 2000-2001) completed the subjective memory complaints questionnaire and underwent Mini-Mental State Examination assessment. Subsequently, the entire cohort was followed for incident stroke until 2012. We used Cox proportional hazard models to estimate the associations between subjective memory complaints and Mini-Mental State Examination, with stroke. Results-During a follow-up of 111 593 person years, 1134 strokes were identified, of which 663 were ischemic and 99 hemorrhagic. In the fully adjusted model, presence of subjective memory complaints was independently associated with a higher risk of stroke (hazard ratio, 1.20; 95% confidence interval, 1.04-1.39), but a higher Mini-Mental State Examination was not (hazard ratio per point increase, 0.99; 95% confidence interval, 0.95-1.02). The association between subjective memory complaints and risk of stroke was modified by educational level, with a higher risk of stroke in persons with a higher level of education (hazard ratio, 1.39; 95% confidence interval, 1.07-1.81). Conclusions-Subjective

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Subjective cognitive complaints and amyloid burden in cognitively normal older individuals

Cited by 418 publications

References 64 publications

Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study

Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study

Self-reported memory complaints

Subjective Memory Complaints and the Risk of Stroke

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