Subjective cognitive complaints are important in PD-MCI criteria: Associations with CSF markers and cognitive decline

Jones, Jacob D.; Rivas, Rhiannon; Luna, Kenya; Ryczek, Cameron A.; Thomas, Kelsey R.

doi:10.1016/j.parkreldis.2022.11.013

Cited by 3 publications

(2 citation statements)

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“…Longitudinal studies could more easily address the nature of this relationship. Indeed, Jones and colleagues (2023), using a large sample of newly diagnosed PD patients, found that those with SCCs had greater cognitive decline and increased biomarker abnormalities over a 5-year period compared to PD individuals without SCCs and controls. Purri and colleagues (2020) identified a similar cognitive trajectory in PD-SCC individuals over 2 years.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding disadvantages, one primary concern is the CCI-20’s susceptibility to mood and motivational influences, necessitating the inclusion of assessments for depression, anxiety, and apathy to account for possible confounds. Additionally, there is no evidence to suggest a comprehensive, multidomain measure of SCCs is superior to a single yes/no question; in fact, some studies have found a single question about the presence of SCCs to be predictive of future cognitive decline in PD (Jones et al, 2023; Purri et al, 2020). Finally, informant-reported SCCs may be more accurate than self-reported SCCs if there is suspicion of underlying cognitive impairment, given concern for underreporting in patients with cognitive dysfunction (Azar et al, 2017; Copeland et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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Perception of cognitive change by individuals with Parkinson’s disease or essential tremor seeking deep brain stimulation: Utility of the cognitive change index

Rodriguez,

Schade,

Lopez

et al. 2023

J Int Neuropsychol Soc

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Objective: The Cognitive Change Index (CCI-20) is a validated questionnaire that assesses subjective cognitive complaints (SCCs) across memory, language, and executive domains. We aimed to: (a) examine the internal consistency and construct validity of the CCI-20 in patients with movement disorders and (b) learn how the CCI-20 corresponds to objective neuropsychological and mood performance in individuals with Parkinson’s disease (PD) or essential tremor (ET) seeking deep brain stimulation (DBS). Methods: 216 participants (N = 149 PD; N = 67 ET) underwent neuropsychological evaluation and received the CCI-20. The proposed domains of the CCI-20 were examined via confirmatory (CFA) and exploratory (EFA) factor analyses. Hierarchical regressions were used to assess the relationship among subjective cognitive complaints, neuropsychological performance and mood symptoms. Results: PD and ET groups were similar across neuropsychological, mood, and CCI-20 scores and were combined into one group who was well educated (m = 15.01 ± 2.92), in their mid-60’s (m = 67.72 ± 9.33), predominantly male (63%), and non-Hispanic White (93.6%). Previously proposed 3-domain CCI-20 model failed to achieve adequate fit. Subsequent EFA revealed two CCI-20 factors: memory and non-memory (p < 0.001; CFI = 0.924). Regressions indicated apathy and depressive symptoms were associated with greater memory and total cognitive complaints, while poor executive function and anxiety were associated with more non-memory complaints. Conclusion: Two distinct dimensions were identified in the CCI-20: memory and non-memory complaints. Non-memory complaints were indicative of worse executive function, consistent with PD and ET cognitive profiles. Mood significantly contributed to all CCI-20 dimensions. Future studies should explore the utility of SCCs in predicting cognitive decline in these populations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Perception of cognitive change by individuals with Parkinson’s disease or essential tremor seeking deep brain stimulation: Utility of the cognitive change index

Rodriguez,

Schade,

Lopez

et al. 2023

J Int Neuropsychol Soc

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Advances in Machine Learning for Mild Cognitive Impairment Recognition in the Elderly

安

2024

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Mild cognitive impairment in Parkinson's disease: current view

Jellinger

2024

Front. Cognit.

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Parkinson's disease (PD), the most common motor movement disorder and second most common neurodegenerative disorder after Alzheimer's disease (AD), is often preceded by a period of mild cognitive impairment (MCI), which is associated with impairment of a variety of cognitive domains including executive function, attention, visuospatial abilities and memory. MCI, a risk factor for developing dementia, affects around 30% of de novo PD patients and can increase to 75% after more than 10 years. While 30–40% remain in the MCI state, up to 60% will convert to dementia. Characteristic findings are slowing of EEG rhythms, frontotemporal hypoperfusion, decreased functional connectivity in the default mode and attentional networks, prefrontal and basal-ganglia-cortical circuits, which often manifests prior to clinical symptoms and overt brain atrophy. The heterogeneity of cognitive phenotypes suggests that a common neurodegenerative process affects multiple functional neuronal networks and neuromodulatory systems that may be superimposed by Lewy body and Alzheimer's-related or other co-pathologies. Sparse neuropathological data for PD-MCI revealed a heterogenous picture with various morphological changes similar to MCI in other diseases. This review highlights the essential epidemiological, clinical, neuroimaging and morphological changes in PD-MCI, available biomarkers, and discusses the heterogenous pathobiological mechanisms involved in its development. In view of its complex pathogenesis, well-designed longitudinal clinico-pathological studies are warranted to clarify the alterations leading to MCI in PD, which may be supported by fluid and neuroimaging biomarkers as a basis for early diagnosis and future adequate treatment modalities of this debilitating disorder.

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Subjective cognitive complaints are important in PD-MCI criteria: Associations with CSF markers and cognitive decline

Cited by 3 publications

References 30 publications

Perception of cognitive change by individuals with Parkinson’s disease or essential tremor seeking deep brain stimulation: Utility of the cognitive change index

Perception of cognitive change by individuals with Parkinson’s disease or essential tremor seeking deep brain stimulation: Utility of the cognitive change index

Advances in Machine Learning for Mild Cognitive Impairment Recognition in the Elderly

Mild cognitive impairment in Parkinson's disease: current view

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