Subjective Cognitive Complaints in Cognitively Healthy Older Adults and Their Relationship to Cognitive Performance and Depressive Symptoms

Marková, Hana; Andel, Ross; Štěpánková, Hana; Kopeček, Miloslav; Nikolai, Tomáš; Hort, Jakub; Thomas‐Antérion, Catherine; Vyhnálek, Martin

doi:10.3233/jad-160970

Cited by 64 publications

(51 citation statements)

References 42 publications

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“…Indeed, Hispanics with SCD [2] as well as Hispanics who endorse more items on a depression scale [23] have an increased risk of developing cognitive decline in the future. Importantly, the present results replicate previous findings in non-Hispanic White community and clinic-based samples [8, 9, 24], contributing to the SCD-I working group’s recommendation to investigate whether or not SCD manifests differently in various racial and ethnic backgrounds.…”

Section: Discussionsupporting

confidence: 87%

“…Third, we cannot address the value that SCD may hold in predicting future cognitive decline in this sample due to the cross-sectional nature of this study. Several research studies have observed minimal cross-sectional associations between SCD reporting and cognitive performance [5, 8, 9, 24], while others have consistently found associations between SCD reporting and biomarkers of Alzheimer’s disease and future cognitive decline [25, 31–33], although this is not always the case [34, 35]. Our current results replicate and extend previous cross-sectional findings in non-Hispanic Whites to a group of Hispanic older adults; however, additional research continues to be needed to determine the value of SCD in predicting future cognitive changes in older Hispanics.…”

Section: Discussionmentioning

confidence: 99%

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Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Zlatar

Muniz

Espinoza

et al. 2018

JAD

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Subjective cognitive decline (SCD) is common in older adults and may be an early marker of future cognitive decline. Research suggest that SCD is more closely related to concurrent symptoms of depression than to objective cognitive performance in non-Hispanic Whites, but it is unknown whether the associations of SCD, cognition, and depression manifest differently in Hispanic older adults. We examined if SCD is associated with objective cognitive performance or with depression symptoms in 145 Hispanic individuals ages 60 or older referred by community health clinics for screening of cognitive complaints. All participants lived near the U.S.-Mexico border, spoke Spanish only, or were Spanish-English bilingual. Memory-only and global cognitive composites were created from scores on Spanish versions of several neuropsychological tests. The Geriatric Depression Scale (GDS) and a five-item SCD questionnaire developed by our group were also completed. Multiple regression analyses showed no significant associations between SCD and memory or global cognitive composite scores after adjusting for age, sex, education, and GDS score. In contrast, there was a significant association between GDS and SCD after adjusting for age, sex, education, global and memory composite scores. Findings suggest that SCD does not accurately reflect current cognitive status in older Hispanics who present to their primary care physician with cognitive complaints. Clinicians should interpret SCD in this population within the context of information about symptoms of depression. Longitudinal research is needed in older Hispanics to better characterize SCD in this population and to determine if it can predict future cognitive decline.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Zlatar

Muniz

Espinoza

et al. 2018

JAD

View full text Add to dashboard Cite

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“…В настоящем исследовании частота жалоб на снижение памяти у больных трудоспособного возраста составила около 45%. По данным литературы [13,14] от 20 до 50% пациентов старше 50 лет жалуются на забывчивость и затруднения в подборе слов.…”

Section: Discussionunclassified

Cognitive disorders in the middle-aged population and cerebrovascular risk factors

Gnedovskaya

Kravchenko

Николаева

et al. 2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Цель исследования. Изучение частоты субъективных (СКН) и объективных когнитивных нарушений (ОКН) в популяции среднего трудоспособного возраста и их ассоциаций с основными и дополнительными факторами риска развития цереброваскулярной патологии. Материал и методы. Методом сплошного скрининга были обследованы 169 мужчин и 239 женщин в возрасте 40-59 лет. Проводились сбор анамнеза, общее и биохимическое исследование крови, электрокардиография, ультразвуковое исследование брахиоцефальных и общих бедренных артерий, эхокардиография, магнитно-резонансная томография головного мозга (МРТ). Объективизация когнитивных нарушений (КН) осуществлялась с помощью проб Лурии и Мюнстерберга. Аффективные нарушения (АН) оценивались с помощью Госпитальной шкалы тревоги и депрессии. Результаты и заключение. Отсутствие СКН и/или ОКН было выявлено у 26,5%. Исключительно СКН имели 10% пациентов, более чем у 35,7% жалобы на когнитивное снижение сопровождались отклонениями по данным тестирования. Около 25% имели ОКН, но не предъявляли жалоб. Средний возраст пациентов с ОКН, имеющих жалобы, был выше, чем в группе нормы. У женщин СКН встречались в 2 раза чаще, а ОКН без жалоб-реже, чем у мужчин. СКН, как и отсутствие КН, чаще наблюдались у лиц с высшим образованием. Распространенность мелкоочагового поражения белого вещества головного мозга по данным МРТ была 36%. Множественные очаги чаще (47%) встречались в группе пациентов с ОКН, предъявлявших жалобы, как и атеросклероз магистральных артерий головы. По данным Госпитальной шкалы тревоги и депрессии среди обследованных лиц преобладали легкие АН. Тревожные расстройства встречались чаще, чем депрессивные. Доля пациентов с АН была выше среди пациентов с ОКН, предъявлявших жалобы. Таким образом, СКН являются распространенным явлением среди лиц 40-60 лет. Использование простых нейропсихологических проб при скрининговом обследовании позволяет выделить группу пациентов, у которых наиболее целесообразен активный поиск сосудистых факторов риска. Тревожно-депрессивные расстройства обусловливают значительную часть КН и являются важной дополнительной мишенью терапевтических мероприятий.

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“…Cognitively intact older adults who report memory problems may be up to twice as likely to develop cognitive impairment 5 to 10 years later, and multiple studies have found accelerated transitions into AD and other dementias after impairment onset . However, some studies demonstrate no association between self‐reported memory and cognitive decline, and others find that memory complaints may be more strongly associated with affective symptoms or personality than with objective cognition . One factor that may contribute to cognitive decline risk is co‐occurring anxiety symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] However, some studies demonstrate no association between self-reported memory and cognitive decline, 11,12 and others find that memory complaints may be more strongly associated with affective symptoms or personality than with objective cognition. [13][14][15] One factor that may contribute to cognitive decline risk is co-occurring anxiety symptoms. Anxiety increases the risk for cognitive decline and AD 16 and may mediate the association between memory complaints and cognitive decline in some older adults.…”

mentioning

confidence: 99%

Predicting current and future anxiety symptoms in cognitively intact older adults with memory complaints

Hill

Mogle

Bell

et al. 2019

Int J Geriat Psychiatry

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Objectives Memory complaints are a common concern for older adults and may co‐occur with anxiety symptoms. Although both memory complaints and anxiety are associated with heightened cognitive decline risk, little is known about how these symptoms develop over time. The purpose of this study was to examine the differential concurrent and longitudinal relationships among anxiety symptoms and two types of memory complaints in cognitively intact older adults. Methods/Design The current study sample was drawn from two longitudinal, nationally representative datasets, the National Health and Aging Trends Study (NHATS) and the Health and Retirement Study (HRS). Cognitively intact older adults aged 65 and over were included, representing six (n = 5069; NHATS) and two (n = 5284; HRS) waves of data, respectively. Using multilevel linear modeling, we tested bidirectional relationships between anxiety and two types of memory complaints: current rating of memory performance and perceived memory decline. Results Concurrent associations between anxiety symptoms and memory complaints were found in both datasets: At times when current memory performance was rated more poorly or perceived memory decline was reported, anxiety symptoms tended to be higher, and vice versa. A longitudinal relationship was identified in NHATS such that perceived memory decline, and not current memory rating, predicted future anxiety symptoms. Conclusion This study provides a better understanding of the relationships between memory complaints and anxiety symptoms over time. Cognitively intact older adults with perceived memory decline are at greater risk for current as well as future anxiety symptoms.

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Subjective Cognitive Complaints in Cognitively Healthy Older Adults and Their Relationship to Cognitive Performance and Depressive Symptoms

Cited by 64 publications

References 42 publications

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Cognitive disorders in the middle-aged population and cerebrovascular risk factors

Predicting current and future anxiety symptoms in cognitively intact older adults with memory complaints

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