Subjective cognitive decline and self‐reported sleep problems: The SCIENCe project

Exalto, Lieza G.; Hendriksen, Heleen M.A.; Barkhof, Frederik; Bosch, Karlijn A. van den; Ebenau, Jarith L.; Leeuwenstijn-Koopman, Mardou van; Prins, Niels D.; Teunissen, Charlotte E.; Visser, Leonie N. C.; Scheltens, Philip; Flier, Wiesje M. van der

doi:10.1002/dad2.12287

Cited by 9 publications

(7 citation statements)

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“…There were no obvious differences in self-reported sleep duration among participants with MCR, but the only SMC and MCR groups had higher proportions of excessive daytime sleepiness than the other groups. This result was in line with the association between sleep concerns and SMC reported by other cross-sectional studies, and sleepiness was reported as an independent risk factor associated with car collisions by a systematic review and meta-analysis . Although the causal relationship between sleep concerns and SMC has not been clarified, sleep concerns may increase the risk of not only car collisions but also SMC.…”

Section: Discussionsupporting

confidence: 93%

Motoric Cognitive Risk Syndrome and Traffic Incidents in Older Drivers in Japan

Kurita,

Doi,

Harada

et al. 2023

JAMA Netw Open

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ImportanceTo prevent motor vehicle collisions by older drivers, the increased risk of collisions should be considered early. Cognitive decline increases the risk of car collisions. Motoric cognitive risk syndrome (MCR), characterized by the presence of cognitive concerns and slow gait, can be assessed conveniently and is useful to assess the risk of dementia.ObjectiveTo examine the association between MCR assessment findings and car collisions among older drivers in Japan.Design, Setting, and ParticipantsThis cross-sectional study used data from a community-based cohort study, the National Center for Geriatrics and Gerontology-Study of Geriatric Syndromes, conducted in Japan from 2015 to 2018. Participants were community-dwelling older adults aged at least 65 years. Data were analyzed from February to March 2023.ExposureMCR was defined as having subjective memory concerns (SMC) and slow gait. Participants were classified into 4 groups: no SMC or slow gait, only SMC, only slow gait, and MCR.Main Outcomes and MeasuresParticipants were asked about the experience of car collisions during the last 2 years and near-miss traffic incidents during the previous year through face-to-face interviews. Odds of experiencing a collision or near-miss traffic incident were assessed using logistic regression.ResultsAmong a total of 12 475 participants, the mean (SD) age was 72.6 (5.2) years, and 7093 (56.9%) were male. The group with only SMC and the group with MCR showed a higher proportion of both car collisions and near-miss traffic incidents than the other groups (adjusted standardized residuals &gt; 1.96; P &lt; .001). Logistic regression analysis showed the only SMC and MCR groups had increased odds of car collisions (only SMC group: odds ratio [OR], 1.48; 95% CI, 1.27-1.72; MCR group: OR, 1.73; 95% CI, 1.39-2.16) and near-miss traffic incidents (only SMC group: OR, 2.07; 95% CI, 1.91-2.25; MCR group: OR, 2.13; 95% CI, 1.85-2.45) after adjusting for confounding factors. After stratifying MCR assessments by objective cognitive impairment, significant associations were still observed. In the only slow gait group, objective cognitive impairment was associated with increased odds of car collisions (OR, 1.96; 95% CI, 1.17-3.28).Conclusions and RelevanceIn this cross-sectional study of community-dwelling older drivers in Japan, SMC and MCR were associated with car collisions and near-miss traffic incidents independent from objective cognitive impairment. Future studies should examine the mechanism of these associations in more detail.

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Section: Discussionsupporting

confidence: 93%

Motoric Cognitive Risk Syndrome and Traffic Incidents in Older Drivers in Japan

Kurita,

Doi,

Harada

et al. 2023

JAMA Netw Open

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“…� not statistically signifcant. have connected SCD with objective memory loss, but not sleep quality with objective memory loss even though sleep quality is associated with SCD [13,14]. Nevertheless, research on such connections in Chinese populations is minimal, and our fndings corroborate the connection between poor sleep and SCD in older residents of Western China [15].…”

Section: Efect Of Sleep On Subjective Cognitive Declinesupporting

confidence: 63%

“…These findings also agree with literature on anxiety and depression independently increasing sleep issues in older adults [ 39 – 41 ]. In addition, the link between sleep quality and SCD is reaffirmed, despite mixed results on the subject—non-Chinese cohort studies have connected SCD with objective memory loss, but not sleep quality with objective memory loss even though sleep quality is associated with SCD [ 13 , 14 ]. Nevertheless, research on such connections in Chinese populations is minimal, and our findings corroborate the connection between poor sleep and SCD in older residents of Western China [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Siddarth et al found objective memory differences between adults who reported SCD and adults without SCD [ 13 ]. However, Exalto et al reported that poorer sleep quality in adults was associated with more severe SCD symptoms but not cognitive testing, MRI, or cerebrospinal fluid biomarker differences [ 14 ]. In addition, there is a lack of SCD and sleep quality literature for Chinese populations, which is necessary considering the increasing incidence of SCD in China.…”

Section: Introductionmentioning

confidence: 99%

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Sleep Quality and Subjective Cognitive Decline among Older Adults: The Mediating Role of Anxiety/Depression and Worries

Sun,

Zhang,

Han

et al. 2024

Journal of Aging Research

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Background. Subjective cognitive decline (SCD) in older individuals has been implicated as a possible precursor to Alzheimer’s disease. Poor sleep quality and anxiety/depressive symptoms have been linked to the progression of SCD, but these associations and older adults’ worries have yet to be fully established in the Chinese older adult population, which is one of the largest in the world. The aim of this study was to explore the relationship between sleep quality, anxiety/depression symptoms, and worries, and SCD prevalence among Chinese community-dwelling older individuals. Methods. A total of 707 adults aged between 60 and 99 from Shanghai, China, completed self-report questionnaires that covered their cognitive and mental well-being, as well as demographic information. Subjective cognitive decline (SCD) was evaluated using the memory/cognition syndromes of the old adult self-report (OASR). Sleep quality, anxiety/depression, and worries were measured from their respective sections of the OASR. Results. The general linear regression models showed that poorer sleep quality was associated with an increased prevalence of anxiety/depression symptoms, worries, and SCD among older adults. As suggested by the mediation analysis, anxiety/depression and worries were significant mediators in the relationship between sleep quality and SCD prevalence, and these two factors also have a serial mediation effect between sleep quality and SCD prevalence. Conclusions. Poorer sleep quality is associated with a higher rate of SCD among older adults, and a higher prevalence of anxiety/depression and worries mediate this relationship, suggesting possible mechanism pathways that lead to SCD. These factors may provide the basis for early, targeted interventions for older adults’ mental health preservation and improved quality of life.

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“…In addition, research on these subtle early symptoms has focused primarily on AD, neglecting other cognitive trajectories that may be characteristic of other forms of dementia progression. It should be noted that SCD has been associated with psychological and personality factors (e.g., stress, neuroticism) [ 214 ], lifestyle and health habits [ 215 , 216 , 217 ], and cognitive reserve [ 218 , 219 ]. However, no conclusive causal relationships have been described, nor how these factors are associated with the SCD subtype [ 220 ].…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological Assessment for Early Detection and Diagnosis of Dementia: Current Knowledge and New Insights

Alzola,

Carnero,

Bermejo-Pareja

et al. 2024

JCM

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Dementia remains an underdiagnosed syndrome, and there is a need to improve the early detection of cognitive decline. This narrative review examines the role of neuropsychological assessment in the characterization of cognitive changes associated with dementia syndrome at different states. The first section describes the early indicators of cognitive decline and the major barriers to their identification. Further, the optimal cognitive screening conditions and the most widely accepted tests are described. The second section analyzes the main differences in cognitive performance between Alzheimer’s disease and other subtypes of dementia. Finally, the current challenges of neuropsychological assessment in aging/dementia and future approaches are discussed. Essentially, we find that current research is beginning to uncover early cognitive changes that precede dementia, while continuing to improve and refine the differential diagnosis of neurodegenerative disorders that cause dementia. However, neuropsychology faces several barriers, including the cultural diversity of the populations, a limited implementation in public health systems, and the adaptation to technological advances. Nowadays, neuropsychological assessment plays a fundamental role in characterizing cognitive decline in the different stages of dementia, but more efforts are needed to develop harmonized procedures that facilitate its use in different clinical contexts and research protocols.

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Subjective cognitive decline and self‐reported sleep problems: The SCIENCe project

Cited by 9 publications

References 55 publications

Motoric Cognitive Risk Syndrome and Traffic Incidents in Older Drivers in Japan

Motoric Cognitive Risk Syndrome and Traffic Incidents in Older Drivers in Japan

Sleep Quality and Subjective Cognitive Decline among Older Adults: The Mediating Role of Anxiety/Depression and Worries

Neuropsychological Assessment for Early Detection and Diagnosis of Dementia: Current Knowledge and New Insights

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