Subjective cognitive impairment of older adults: a comparison between the US and China

Wu, Qiong

doi:10.1002/mpr.1499

Cited by 14 publications

(13 citation statements)

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“…Several limitations of this study should be addressed. First, SCD is a heterogeneous state and it is affected by the cultural background [ 14 , 15 ]. Previous studies on its metabolism were inconsistent [ 12 , 13 , 30 , 31 , 33 – 35 ], and our results led to new conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…FDG-PET images were used to detect glucose metabolism in brains in vivo. SCD subjects from Han populations were included in this study to exclude the possible influence of different cultural backgrounds [ 14 , 15 ]. To reduce the influence of data selection, the subjects in our study were from two tertiary medical centers, and we performed permutation tests and repeated cross-validations to improve the robustness of the results.…”

Section: Introductionmentioning

confidence: 99%

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Glucose metabolism in the right middle temporal gyrus could be a potential biomarker for subjective cognitive decline: a study of a Han population

Dong

Jiang

et al. 2021

Alz Res Therapy

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Introduction Subjective cognitive decline (SCD) represents a cognitively normal state but at an increased risk for developing Alzheimer’s disease (AD). Recognizing the glucose metabolic biomarkers of SCD could facilitate the location of areas with metabolic changes at an ultra-early stage. The objective of this study was to explore glucose metabolic biomarkers of SCD at the region of interest (ROI) level. Methods This study was based on cohorts from two tertiary medical centers, and it was part of the SILCODE project (NCT03370744). Twenty-six normal control (NC) cases and 32 SCD cases were in cohort 1; 36 NCs, 23 cases of SCD, 32 cases of amnestic mild cognitive impairment (aMCIs), 32 cases of AD dementia (ADDs), and 22 cases of dementia with Lewy bodies (DLBs) were in cohort 2. Each subject underwent [18F]fluoro-2-deoxyglucose positron emission tomography (PET) imaging and magnetic resonance imaging (MRI), and subjects from cohort 1 additionally underwent amyloid-PET scanning. The ROI analysis was based on the Anatomical Automatic Labeling (AAL) template; multiple permutation tests and repeated cross-validations were conducted to determine the metabolic differences between NC and SCD cases. In addition, receiver operating characteristic curves were used to evaluate the capabilities of potential glucose metabolic biomarkers in distinguishing different groups. Pearson correlation analysis was also performed to explore the correlation between glucose metabolic biomarkers and neuropsychological scales or amyloid deposition. Results Only the right middle temporal gyrus (RMTG) passed the methodological verification, and its metabolic levels were correlated with the degrees of complaints (R = − 0.239, p = 0.009), depression (R = − 0.200, p = 0.030), and abilities of delayed memory (R = 0.207, p = 0.025), and were weakly correlated with cortical amyloid deposition (R = − 0.246, p = 0.066). Furthermore, RMTG metabolism gradually decreased across the cognitive continuum, and its diagnostic efficiency was comparable (NC vs. ADD, aMCI, or DLB) or even superior (NC vs. SCD) to that of the metabolism of the posterior cingulate cortex or precuneus. Conclusions These findings suggest that the hypometabolism of RMTG could be a typical feature of SCD, and the large-scale hypometabolism in patients with symptomatic stages of AD may start from the RMTG, which gradually progresses starting in the preclinical stage. The specificity of identifying SCD from the perspective of self-perceived symptoms is likely to be increased by the detection of RMTG metabolism.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Glucose metabolism in the right middle temporal gyrus could be a potential biomarker for subjective cognitive decline: a study of a Han population

Dong

Jiang

et al. 2021

Alz Res Therapy

View full text Add to dashboard Cite

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“…This highlights the importance of not solely relying on psychometric data for diagnostic purpose, but also integrating information on the reported course of cognitive change and their impact on daily function for individual patients. However, it is important to note that individuals’ perception of their own cognition, mood, and general health, and their subjective complaints are not free for cultural bias either (Karasz, 2005; Jürges, 2007; Mograbi et al, 2012; Wu, 2016; Molina, 2017; Rossouw et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Origins Matter: Culture Impacts Cognitive Testing in Parkinson’s Disease

Statucka

Cohn

2019

Front. Hum. Neurosci.

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Cognitive decline is common in Parkinson’s disease (PD), and precise cognitive assessment is important for diagnosis, prognosis, and treatment. To date, there are no studies in PD investigating cultural bias on neuropsychological tests. Clinical practice in multicultural societies such as, Toronto Canada where nearly half of the population is comprised of first generation immigrants, presents important challenges as most neuropsychological tools were developed in Anglosphere cultures (e.g., USA, UK) and normed in more homogeneous groups. We examine total scores and rates of deficits on tests of visuoperceptual/visuospatial, attention, memory, and executive functions in Canadians with PD born in Anglosphere countries ( n = 248) vs. in Canadians with PD born in other regions (International group; n = 167). The International group shows lower scores and greater rates of deficits on all visuoperceptual and some executive function tasks, but not on attention or memory measures. These biases are not explained by demographic and clinical variables as groups were comparable. Age at immigration, years in Canada, and English proficiency also do not account for the observed biases. In contrast, group differences are strongly mediated by the Historical Index of Human Development of the participants’ country of birth, which reflects economic, health, and educational potential of a country at the time of birth. In sum, our findings demonstrate lasting biases on neuropsychological tests despite significant exposure to, and participation in, Canadian culture. These biases are most striking on visuoperceptual measures and non-verbal executive tasks which many clinicians still considered to be “culture-fair” despite the growing evidence from the field of cross-cultural neuropsychology to the contrary. Our findings also illustrate that socio-development context captures important aspects of culture that relate to cognition, and have important implications for clinical practice.

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“…Finally, cultural factors were found to impact SCD by a cross-cultural comparison between the USA and China,21 which indicates the need for SCD research in China. SILCODE is a longitudinal study in China, and the implementation of SILCODE would provide characteristics of SCD in China, which contribute to the harmonisation of the SCD concept across cultural borders.…”

Section: Discussionmentioning

confidence: 98%

“…Though some longitudinal and observational studies of SCD are ongoing,18–20 there are few data available from China or anywhere else in Asia. However, SCD is subject to influence by various cultural factors including factors that relate to language, social stigmatisation of cognitive problems, styles of responding on self-reported measures (eg, extremity of answers), tolerance of slowly progressive cognitive decline in ageing and others 21. The association between objective cognitive performance and SCD is different across races 22.…”

Section: Introductionmentioning

confidence: 99%

Sino Longitudinal Study on Cognitive Decline (SILCODE): protocol for a Chinese longitudinal observational study to develop risk prediction models of conversion to mild cognitive impairment in individuals with subjective cognitive decline

Wang

et al. 2019

BMJ Open

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IntroductionUnderstanding the biological mechanism of subjective cognitive decline (SCD) in preclinical Alzheimer’s disease (AD) and identifying those who will soon convert to mild cognitive impairment (MCI) are critical for developing appropriate strategies for early diagnosis and intervention of AD. We present the study protocol of the Sino Longitudinal Study on Cognitive Decline (SILCODE), a longitudinal observational study focusing on SCD in the context of AD.Methods and analysisWithin SILCODE, approximately 800 subjects with SCD who are between 50 and 79 years old will be recruited through standardised public advertisements or memory clinics. They will undergo extensive assessment, including clinical and neuropsychological assessments, blood sample collection for plasma beta-amyloid and ApoE genotype, urine samples collection for AD7c-NTP, and multimodal MRI scans (structural MRI, diffusion tensor imaging, resting-state functional MRI and optional task-based functional MRI) as well as optional glucose metabolism and amyloid positron emission tomography. Subjects will be contacted by telephone every 3 months and interviewed, on average, every 15 months for 5 years. The study endpoint is the development of mild cognitive impairment or dementia. Jak & Bondi’s actuarial neuropsychological method will be used for diagnosis of MCI. The least absolute shrinkage and selection operator logistic regression model followed by the sub-distribution hazard function model with death as a competing risk will be constructed to establish risk prediction models.Ethics and disseminationThe ethics committee of the Xuanwu Hospital of Capital Medical University has approved this study protocol (ID: [2017]046). The results will be published in peer-reviewed journals and presented at national and international scientific conferences.Trial registration numberNCT03370744; Pre-results.

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Subjective cognitive impairment of older adults: a comparison between the US and China

Cited by 14 publications

References 30 publications

Glucose metabolism in the right middle temporal gyrus could be a potential biomarker for subjective cognitive decline: a study of a Han population

Glucose metabolism in the right middle temporal gyrus could be a potential biomarker for subjective cognitive decline: a study of a Han population

Origins Matter: Culture Impacts Cognitive Testing in Parkinson’s Disease

Sino Longitudinal Study on Cognitive Decline (SILCODE): protocol for a Chinese longitudinal observational study to develop risk prediction models of conversion to mild cognitive impairment in individuals with subjective cognitive decline

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