Subjective memory complaints and depression as clinical symptoms of disseminated nocardiosis by <i>Nocardia abscessus</i>

Introduction. Nocardia infections are being increasingly reported in both immunocompetent and immunocompromised patients. We describe a case of Nocardia abscessus infection with an atypical presentation in an immunocompetent patient. Case Presentation. A previously healthy 47-year-old gentleman presented with hiccups and paroxysmal spasms. Imaging revealed a pulmonary nodule, for which he underwent surgical resection. Pathologic evaluation demonstrated evidence of local inflammation, with growth of Nocardia abscessus on tissue cultures. Conclusion. Nocardia abscessus may have atypical presentations in immunocompetent patients. Further research is needed to understand the factors leading to Nocardia infections in immunocompetent patients.

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“…In comparison to other Nocardia species, N. abscessus infections have been less commonly reported in the literature [3–8, 10–26] (). N.…”

Section: Discussionmentioning

confidence: 99%

“…In comparison to other Nocardia species, N. abscessus infections have been less commonly reported in the literature [3][4][5][6][7][8][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] (Table 1). N. abscessus infections have been seen to occur mostly in adults, in both immunocompetent and immunocompromised patients.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of Nocardia abscessus infection in an immunocompetent patient

Khatri

Esposito

Koshy

2022

Access Microbiology

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The emergence of rare nocardiosis following allogeneic hematopoietic stem cell transplantation in the era of molecular taxonomy

Kurosawa

Sekiya

Doki

et al. 2019

International Journal of Infectious Diseases

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The purpose of this study was to describe the clinical features of nocardiosis after allogeneic hematopoietic stem cell transplantation (allo-HSCT), focusing on new Nocardia species. Methods: We retrospectively reviewed data from patients with nocardiosis after allo-HSCT treated at our hospital and documented cases in the medical literature. Results: Fifty-seven cases were identified from our institution and the literature review. Although 51 patients (89.5%) responded to initial treatment, 28 (49.1%) patients were switched over to other treatment regimens due to the recurrence of nocardiosis or adverse events of antimicrobials. Nocardiosis-attributed mortality occurred in ten patients (17.5%). Antimicrobial susceptibilities varied among intra-and inter-species except linezolid (LZD). In the present study, five species were newly discovered after 2000, including N. cyriacigeorgica, N. veterana, N. abscessus, N. aobensis, and N. mexicana. All isolates of N. cyriacigeorgica, N. veterana, N. abscessus, and N. aobensis were sensitive to trimethoprim/ sulfamethoxazole, amikacin (AMK), imipenem (IPM), and LZD; however, N. mexicana was resistant to AMK and IPM. Conclusion: Newly identified Nocardia species have various antimicrobial susceptibility patterns. Longterm maintenance therapy could be challenging due to the adverse events of antimicrobials, especially in the allo-HSCT setting. Prudent evaluation is crucial for selecting a second-line or further treatment options.

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Subjective memory complaints and depression as clinical symptoms of disseminated nocardiosis by Nocardia abscessus

Cited by 2 publications

References 4 publications

Unusual presentation of Nocardia abscessus infection in an immunocompetent patient

Unusual presentation of Nocardia abscessus infection in an immunocompetent patient

The emergence of rare nocardiosis following allogeneic hematopoietic stem cell transplantation in the era of molecular taxonomy

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