Subjective memory decline in Parkinson's disease patients with and without fatigue

Siciliano, Mattia; Trojano, Luigi; Russo, Antonio; Tedeschi, Gioacchino; Tessitore, Alessandro

doi:10.1016/j.parkreldis.2019.11.017

Cited by 13 publications

(26 citation statements)

References 31 publications

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“…[ 48 , 50 ]). However, this association has been scarcely investigated in PD, and conflicting results have been reported [ 19 , 22 ]. In PD, Kluger et al [ 51 ] proposed that fatigue, defined as a significantly diminished level of energy or increased perception of effort that is disproportionate to attempted activities [ 52 ], may be linked more to altered subjective awareness than to actual performance limitations.…”

Section: Discussionmentioning

confidence: 99%

“…However, no conclusive evidence is available regarding the possible relationship with other common behavioral symptoms in PD (e.g., apathy, anxiety, fatigue, sleep disorders) or demographic and clinical features. For example, some studies showed that subjective cognitive complaints were more strongly related to anxiety [ 21 ] or fatigue [ 22 ] than to objective cognitive impairment, although other studies did not confirm this relationship [ 19 ]. These conflicting results may have stemmed from differences in the experimental designs and methodological approaches across studies, for instance the use of brief vs. more comprehensive behavioral evaluations.…”

Section: Introductionmentioning

confidence: 99%

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Correlates of the discrepancy between objective and subjective cognitive functioning in non-demented patients with Parkinson’s disease

Siciliano,

Trojano,

De Micco

et al. 2021

J Neurol

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Background Subjective complaints of cognitive deficits are not necessarily consistent with objective evidence of cognitive impairment in Parkinson’s disease (PD). Here we examined the factors associated with the objective-subjective cognitive discrepancy. Methods We consecutively enrolled 90 non-demented patients with PD who completed the Parkinson’s Disease Cognitive Functional Rating Scale (subjective cognitive measure) and the Montreal Cognitive Assessment (MoCA; objective cognitive measure). The patients were classified as “Overestimators”, “Accurate estimators”, and “Underestimators” on the basis of the discrepancy between the objective vs. subjective cognitive measures. To identify the factors distinguishing these groups from each other, we used chi-square tests or one-way analyses of variance, completed by logistic and linear regression analyses. Results Forty-nine patients (54.45%) were classified as “Accurate estimators”, 29 (32.22%) as “Underestimators”, and 12 (13.33%) as “Overestimators”. Relative to the other groups, the “Underestimators” scored higher on the Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), and Parkinson Anxiety Scale (p < 0.01). Logistic regression confirmed that FSS and BDI scores distinguished the “Underestimators” group from the others (p < 0.05). Linear regression analyses also indicated that FSS and BDI scores positively related to objective-subjective cognitive discrepancy (p < 0.01). “Overestimators” scored lower than other groups on the MoCA’s total score and attention and working memory subscores (p < 0.01). Conclusion In more than 45% of consecutive non-demented patients with PD, we found a ‘mismatch’ between objective and subjective measures of cognitive functioning. Such discrepancy, which was related to the presence of fatigue and depressive symptoms and frontal executive impairments, should be carefully evaluated in clinical setting.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlates of the discrepancy between objective and subjective cognitive functioning in non-demented patients with Parkinson’s disease

Siciliano,

Trojano,

De Micco

et al. 2021

J Neurol

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“…In particular, many studies have not distinguished SCCs in normal cognition from those in PD-MCI or PD with dementia. [19][20][21] This review aims to provide an overview of how SCCs in cognitively normal patients with PD have been defined and assessed and to examine the association between SCCs and objective cognitive performance. This review also explores the clinical significance of SCCs supported by their predictive power for subsequent cognitive decline and their association with biomarkers relevant to cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

“…Studies presenting results for SCCs in PD have been rapidly increasing; however, the methodologies for defining SCCs, selecting participants, and interpreting results have shown substantial inconsistencies. In particular, many studies have not distinguished SCCs in normal cognition from those in PD-MCI or PD with dementia [ 19 - 21 ]. This review aims to provide an overview of how SCCs in cognitively normal patients with PD have been defined and assessed and to examine the association between SCCs and objective cognitive performance.…”

Section: Introductionmentioning

confidence: 99%

Subjective Cognitive Complaints in Cognitively Normal Patients With Parkinson’s Disease: A Systematic Review

Hong

Lee²

2023

JMD

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Subjective cognitive complaints (SCCs) refer to self-perceived cognitive decline and are related to objective cognitive decline. SCCs in cognitively normal individuals are considered a preclinical sign of subsequent cognitive impairment due to Alzheimer's disease, and SCCs in cognitively normal patients with Parkinson's disease (PD) are also gaining attention. The aim of this review was to provide an overview of the current research on SCCs in cognitively normal patients with PD. A systematic search found a lack of consistency in the methodologies used to define and measure SCCs. Although the association between SCCs and objective cognitive performance in cognitively normal patients with PD is controversial, SCCs appear to be predictive of subsequent cognitive decline. These findings support the clinical value of SCCs in cognitively normal status in PD; however, further convincing evidence from biomarker studies is needed to provide a pathophysiological basis for these findings. Additionally, a consensus on the definition and assessment of SCCs is needed for further investigations.

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“…Further, a previous study found that depression, anxiety, and apathy were associated with SCCs ( 6 ). Recently, one study found that the patients with fatigue had a 4.97 times higher risk of SCCs than those without fatigue ( 14 ). Thus, limited information is available on the impact of non-motor symptoms of PD other than mood disorders and fatigue on SCCs.…”

Section: Introductionmentioning

confidence: 99%

Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease

Xiao

Yang

et al. 2021

Front. Neurol.

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Background: Subjective cognitive complaints (SCCs), which are associated with a higher risk of cognitive decline, are widespread in the patients with Parkinson's disease (PD). The previous studies have reported inconsistent factors related to SCCs in the patients with late-onset PD (LOPD), and there is limited information on SCCs in the patients with early-onset PD (EOPD).Objective: We aimed to investigate the factors associated with SCCs in the drug-naïve patients with EOPD and LOPD without cognitive impairment.Methods: This cross-sectional study included 332 drug-naïve patients with PD, among whom 134 were EOPD and 198 were LOPD. Motor and non-motor symptoms, such as global objective cognitive status, depression, anxiety, apathy, fatigue, sleep, rapid eye movement sleep behavior disorder, orthostatic hypotension, and excessive daytime sleepiness, were assessed.Results: Twenty-five (18.66%) patients with EOPD and 49 (24.74%) patients with LOPD reported SCCs. A multivariate binary logistic regression analysis revealed that older age at onset [odds ratio (OR) = 1.24, P = 0.002], higher apathy score (OR = 1.13, P = 0.003), and lower scores in the visuospatial/executive abilities (OR = 0.25, P < 0.001) and memory (OR = 0.50, P = 0.024) domains of the Montreal Cognitive Assessment were associated with a higher risk of SCCs in the EOPD group. Higher apathy (OR = 1.06, P = 0.011) and anxiety (OR = 1.14, P < 0.001) scores were associated with SCCs in the LOPD group.Conclusion: Subjective cognitive complaints are only associated with mood disorders in patients with LOPD. In addition, SCCs may reflect subthreshold cognitive impairment in the patients with EOPD.

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Subjective memory decline in Parkinson's disease patients with and without fatigue

Cited by 13 publications

References 31 publications

Correlates of the discrepancy between objective and subjective cognitive functioning in non-demented patients with Parkinson’s disease

Correlates of the discrepancy between objective and subjective cognitive functioning in non-demented patients with Parkinson’s disease

Subjective Cognitive Complaints in Cognitively Normal Patients With Parkinson’s Disease: A Systematic Review

Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease

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