Subjective Outcomes of Auditory Brainstem Implantation

McSorley, Amanda; Freeman, Simon; Ramsden, R. T.; Motion, Jamie; King, Andrew; Rutherford, Scott A.; Mawman, Deborah; O’Driscoll, Martin; Lloyd, Simon

doi:10.1097/mao.0000000000000671

Cited by 12 publications

(5 citation statements)

References 12 publications

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“…Seven out of 10 patients with tinnitus before the implantation reported a decrease in their tinnitus loudness during stimulation with the ABI 12. This finding was confirmed in several other clinical studies, showing a reduction of tinnitus in patients who suffered from tinnitus before ABI implantation after removal of vestibular schwannoma 13–15…”

Section: Introductionsupporting

confidence: 75%

An auditory brainstem implant for treatment of unilateral tinnitus: protocol for an interventional pilot study

et al. 2019

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IntroductionTinnitus may have a very severe impact on the quality of life. Unfortunately, for many patients, a satisfactory treatment modality is lacking. The auditory brainstem implant (ABI) was originally indicated for hearing restoration in patients with non-functional cochlear nerves, for example, in neurofibromatosis type II. In analogy to a cochlear implant (CI), it has been demonstrated that an ABI may reduce tinnitus as a beneficial side effect. For tinnitus treatment, an ABI may have an advantage over a CI, as cochlear implantation can harm inner ear structures due to its invasiveness, while an ABI is presumed to not damage anatomical structures. This is the first study to implant an ABI to investigate its effect on intractable tinnitus.Methods and analysisIn this pilot study, 10 adults having incapacitating unilateral intractable tinnitus and ipsilateral severe hearing loss will have an ABI implanted. The ABI is switched on 6 weeks after implantation, followed by several fitting sessions aimed at finding an optimal stimulation strategy. The primary outcome will be the change in Tinnitus Functioning Index. Secondary outcomes will be tinnitus burden and quality of life (using Tinnitus Handicap Inventory and Hospital Anxiety and Depression Scale questionnaires), tinnitus characteristics (using Visual Analogue Scale, a tinnitus analysis), safety, audiometric and vestibular function. The end point is set at 1 year after implantation. Follow-up will continue until 5 years after implantation.Ethics and disseminationThe protocol was reviewed and approved by the Institutional Review Board of the University Medical Centre Groningen, The Netherlands (METc 2015/479). The trial is registered atwww.clinicialtrials.govand will be updated if amendments are made. Results of this study will be disseminated in peer-reviewed journals and at scientific conferences.Trial registration numberNCT02630589.Trial statusInclusion of first patient in November 2017. Data collection is in progress. Trial is open for further inclusion. The trial ends at 5 years after inclusion of the last patient.

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Section: Introductionsupporting

confidence: 75%

An auditory brainstem implant for treatment of unilateral tinnitus: protocol for an interventional pilot study

et al. 2019

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“…There were three papers that report subjective benefits of ABI. 47,58,59 The mean duration of daily use in these series ranged from 8.5 to 13 hours with a range of 4 to 16 hours a day. 95% to 100% of patients were able to differentiate between speech T A B L E 2 Summary table of hearing preservation rates following the use of bevacizumab in patients with NF2 Likely to be some duplication in data as one author published two papers, the latter with more patients and longer follow-up (Plotkin 2009, Plotkin 2012).…”

Section: Outcomes Of Auditory Brainstem Implantationmentioning

confidence: 92%

“…There were three papers that report subjective benefits of ABI . The mean duration of daily use in these series ranged from 8.5 to 13 hours with a range of 4 to 16 hours a day.…”

Section: Literature Reviewmentioning

confidence: 99%

Hearing optimisation in neurofibromatosis type 2: A systematic review

Lloyd

King

Rutherford

et al. 2017

Clinical Otolaryngology

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This review summarises the current literature related to hearing preservation/rehabilitation in patients with NF2. Whilst it provides indicative data, the quality of the data was low and should be interpreted with care. It is also important to consider that the management of vestibular schwannomas in NF2 is complex and decision-making is determined by many factors, not just the need to preserve hearing.

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“…Colletti 2006; Noij et al 2015; Yücel 2015), but the majority experience is limited to sound detection and speech pattern perception, both of which enhance lip-reading. In addition, there is subject-to-subject variability in 1) number and distribution of electrodes that elicit auditory sensations and 2) the number of electrodes that produce non-auditory side effects and are turned off during a subject’s ABI programming (Behr et al 2014; McSorley et al 2015; Noij et al 2015). Variable success with the ABI has been attributed to various causes, including damage to specific populations of cells in the cochlear nucleus (Colletti and Shannon 2005).…”

Section: Introductionmentioning

confidence: 99%

Auditory Brainstem Implant Array Position Varies Widely Among Adult and Pediatric Patients and Is Associated With Perception

et al. 2017

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Objectives The auditory brainstem implant (ABI) provides sound awareness to patients who are ineligible for cochlear implantation. Auditory performance varies widely among similar ABI cohorts. We hypothesize that differences in electrode array position contribute to this variance. Herein, we classify ABI array position based on postoperative imaging and investigate the relationship between position and perception. Design Retrospective review of pediatric and adult ABI users with postoperative computed tomography (CT). To standardize views across subjects, true-axial reformatted series of scans were created using the McRae line. Using multiplanar reconstructions, basion and electrode array tip coordinates and array angles from vertical were measured. From a lateral view, array angles (V) were classified into Types I-IV, and from posterior view, array angles (T) were classified into Types A-D. Array position was further categorized by measuring distance vertical from basion (D1) and lateral from midline (D2). Differences between array classifications were compared with audiometric thresholds, number of active electrodes, and pitch ranking. Results Pediatric (n=4, 2 with revisions) and adult (n=7) ABI subjects were included in this study. Subjects had a wide variety of ABI array angles, but most were aimed superiorly and posteriorly (Type II, n=7) from lateral view and upright or medially tilted from posterior view (Type A, n=6). Mean pediatric distances were 8 – 42% smaller than adults for D1 and D2. In subjects with perceptual data, electrical thresholds and the number of active electrodes differed among classification types. Conclusions In this first study to classify ABI electrode array orientation, array position varied widely. This variability may explain differences in auditory performance.

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Subjective Outcomes of Auditory Brainstem Implantation

Cited by 12 publications

References 12 publications

An auditory brainstem implant for treatment of unilateral tinnitus: protocol for an interventional pilot study

An auditory brainstem implant for treatment of unilateral tinnitus: protocol for an interventional pilot study

Hearing optimisation in neurofibromatosis type 2: A systematic review

Auditory Brainstem Implant Array Position Varies Widely Among Adult and Pediatric Patients and Is Associated With Perception

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