The modern transformation of the role of education affects the consideration and improvement of the methodological princes of education. At the same time, the constant development of the educational sector entails the justification of the use of certain scientific innovations and advanced technologies in the system of higher education, which is the actual task of this pedagogical research. The object of the study is innovation and advanced technology in higher education. The aim of the work is to highlight innovative means, methods, and technologies in higher education, which are promising mechanisms for improving the university system of Latvia. Pedagogical methods of research (theoretical and empirical) are used in the work. Among theoretical methods of pedagogical cognition, we will distinguish analysis, synthesis, concretization, and abstraction, systemic and functional methods. The empirical methods of research used observation, experiment, and rating method, the basis of which formed the key recommendations for the implementation of the analyzed learning technologies. The results analyzed a number of problems, in particular, the issues of innovative changes in European higher education, modern advanced technologies of learning in higher education, innovative, methods, forms of development of higher education, the problem of STEM-education functioning in Latvia. The scientific novelty of the research is the proposed synthetic analysis of actual innovative methods and technologies in the system of higher education. The practical value of the work consists in the formation of recommendations for further use of innovative methods of higher education development. In the conclusion, it is summarized that the use of innovative teaching methods is an important part of modern European education. At the same time, the main advanced technologies turn to the individual development of the student, improvement of his practical skills.